Université Paris Saclay / Université Paris Descartes

Regulation of microtubule dynamics and functions

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Neurodegeneration
tubulin code
microtubule cytoskeleton
posttranslational modifications
neuronal differentiation

ENP label: 

2015

Research Center / Institute: 

Institut Curie - Centre de Recherche - Paris/Orsay

Research Unit Code: 

UMR3348

Microtubules are key cytoskeletal elements involved in a large number of functions in eukaryotic cells. They assemble from a protein dimer of a- and b-tubulin, two highly similar and conserved proteins. Tubulins are subject to a large variety of posttranslational modifications, which provide a rapid and reversible mechanism to diversify microtubule functions in cells. Our team is studying the mechanisms and functional roles of these modifications by using an interdisciplinary approach.

Leader

Leader: 

Personal

Team members: 

Annemarie Wehenkel
Cecilia Serieyssol
Kathiresan Natarajan
Laurence Vaslin
Maria Magiera
Ngoc-Lan Julie Nguyen
Sudarshan Gadadhar
Tiziana Giordano
Lurlene Akendengue
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Institut Curie
Université Paris Sud 11

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

SDSV / FdV
Laboratory

Initiatives d'Excellence: 

Labex CelTisPhyBio, contrat ANR, équipe FRM
Publications

Publications: 

Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bieche I, Rusconi F, Janke C (2017) Tubulin glycylation controls primary cilia length. J Cell Biol 216: 2701-2713

Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H (2015) Microtubule detyrosination guides chromosomes during mitosis. Science 348: 799-803

Nirschl JJ, Magiera MM, Lazarus JE, Janke C, Holzbaur ELF (2016) alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep: celrep 2509

Belvindrah R, Natarajan K, Shabajee P, Bruel-Jungerman E, Bernard J, Goutierre M, Moutkine I, Jaglin XH, Savariradjane M, Irinopoulou T, Poncer J-C, Janke C, Francis F (2017) Mutation of the alpha-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration. J Cell Biol 216: 2443-2461

Bosch Grau M, Masson C, Gadadhar S, Rocha C, Tort O, Marques Sousa P, Vacher S, Bieche I, Janke C (2017) Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. J Cell Sci 130: 938-949

 

Imaging and Psychiatry

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
schizophrenia
autism
Brain imaging
addiction

ENP label: 

2012

Research Center / Institute: 

Imagen Orsay Service Hospitalier Frédéric Joliot

Research Unit Code: 

U1000

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CEA

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

ED158
Laboratory

Surname: 

Laboratoire Imagerie et Psychiatrie

Initiatives d'Excellence: 

IHU Necker
Publications

Publications: 

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192