Université Pierre et Marie Curie

Mice, Molecules and Synapse formation

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Synapses, molecules, transgenesis, mice, development

ENP label: 

2007

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR 7241 - U1050

Le cerveau est composé de nombreux types de neurones communiquant entre eux via descontacts spécifiques, les synapses. Chaque neurone peut être contacté par plusieurs typesde neurones et à son tour peut envoyer des connections sur différentes autres populationsneuronales : la structure de ces réseaux peut être comparée à celle des réseauxélectriques. Comment la formation de ces réseaux précis est contrôlée reste encore malcompris. Toute perturbation de leur formation peut entraîner des maladies neurodévelopmentales du type autisme.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Center for Interdisciplinary Research in Biology

Initiatives d'Excellence: 

Labex Memolife Idex PSL* ERC Consolidator Grant 2016
Publications

Publications: 

 

Usardi A, Iyer K, Sigoillot SM, Dusonchet A, Selimi F. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Dev Neurobiol. 2017 Jan;77(1):75-92. doi: 10.1002/dneu.22412. Epub 2016 Jul 8. PubMed PMID: 27328461.

Sigoillot SM, Iyer K, Binda F, González-Calvo I, Talleur M, Vodjdani G, Isope P, Selimi F. The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] PubMed PMID: 25660030.

Proville RD, Spolidoro M, Guyon N, Dugué GP, Selimi F, Isope P, Popa D, Léna C. Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements. Nat Neurosci. 2014 Sep;17(9):1233-9. doi: 10.1038/nn.3773. Epub 2014 Jul 27. PubMed PMID: 25064850.

Chaumont J, Guyon N, Valera AM, Dugué GP, Popa D, Marcaggi P, Gautheron V, Reibel-Foisset S, Dieudonné S, Stephan A, Barrot M, Cassel JC, Dupont JL, Doussau F, Poulain B, Selimi F, Léna C, Isope P. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16223-8. doi: 10.1073/pnas.1302310110. Epub 2013 Sep 17. PubMed PMID: 24046366; PubMed Central PMCID: PMC3791757.

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. PubMed PMID: 23628982; PubMed Central PMCID: PMC3730300.

 

Audition Team

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

memory, learning, plasticity, human psychophysics, physiology in behaving ferrets

ENP label: 

2017

Research Center / Institute: 

ENS Ecole Normale Supérieure

Research Unit Code: 

UMR 8248

The Audition team is investigating the mechanisms of auditory perception, at the interface between low-level processing of acoustic features and high-level cognitive processes. We use a wide range of tools in order to address this research topic, from single unit recordings in behaving animals to advanced psychophysics and EEG in human subjects. Current projects in the lab revolve around three major threads:

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Ecole Normale Supérieure

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 3C - 158
Laboratory

Surname: 

Laboratoire des Systèmes Perceptifs

Initiatives d'Excellence: 

LabEx Institut d’Etude de la Cognition, IdEx Paris Sciences et Lettres
Publications

Publications: 

Agus, T.R., Thorpe, S.J., & Pressnitzer, D. (2010). Rapid formation of auditory memories: Insights from noise. Neuron. 66, 610-618.

Andrillon, T., Pressnitzer, D., Léger, D., & Kouider, S. (2017).Formation and suppression of acoustic memories in human sleep. NatureCommunications, 8: 179.

Boubenec Y, Lawlor J, Górska U, Shamma S & Englitz B (2017). Detecting changes in dynamic and complex acoustic scenes. eLife 2017;10.7554/eLife.24910.

Chambers, C., Akram, S. Adam, V., Pelofi, C., Sahani, M., Shamma, S., & Pressnitzer, D. (2017). Prior context in audition informs binding and shapes simple features. Nature Communications, 8:15027.

Andrillon, T., Kouider, S., Agus, T., & Pressnitzer, D. (2015).Perceptual learning of acoustic noise generates memory-evoked potentials. Current Biology, 25: 2823-2829.

 

ORENDORFF Elaine

Program entrance date (month year): 

September 2016

Level: 

Year 4

Date Graduate program year 2,3,4: 

November 1, 2017 - September 30, 2020

University: 

Sorbonne Université

Doctoral School Code: 

ED158

Thesis Supervisor: 

Thesis title: 

Selective Amacrine Cell Stimulation, Imaging, and Downstream Recording Across Dedicated Circuits of the Retina

Neuroimaging and behavior of the zebrafish

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

light-sheet microscopy
neuroimaging
zebrafish
sensory-motor integration
circuit inference

ENP label: 

2016

Research Center / Institute: 

Laboratoire Jean Perrin

Research Unit Code: 

UMR 8237

The overall objective of the group is to unravel principles of neural computations underlying sensory-motor integration in thevertebrate brain. We use the zebrafish larva as a model since it currently constitutes the only vertebrate system amenable towhole-brain recording with cellular resolution. Using one- or two-photon light-sheet microscopy, we are able to monitor the long-termactivity of the quasi-entirety of the 100,000 neurons that comprise the animal brain, as it performs basic sensory-motor tasks.

Leader

Leader: 

Personal

Team members: 

Raphaël Candelier
Sergei Kruglik
Sébastien Wolf
Alexis Dubreuil
Sophia Karpenko
Guillaume Le Goc
Institutions

Principal Institution: 

UPMC

Affiliated institutions: 

CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 564
Publications

Publications: 

Whole-brain functional imaging with two-photon light-sheet microscopy, S Wolf, W. Supatto, G. Debrégeas, P. Mahou, S. G Kruglik,J-M. Sintes, E. Beaurepaire, R. Candelier Nature Methods 12, 379–380 (2015)

An Amplitude Modulation/Demodulation Scheme for Whisker-Based Texture Perception, Y. Boubenec, L. N. Claverie, D. E. Shulz,G. Debrégeas, J. Neurosci. 34(33): 10832-10843 (2014)

Fast functional imaging of multiple brain regions in intact zebrafish larvae using Selective Plane Illumination Microscopy. T. Panier,S. Romano, R. Olive, T. Pietri, G. sumbre, R. Candelier, G. Debrégeas, Frontiers in Neural Circuits 7, 0065 (2013)

The role of fingerprints in the coding of tactile information probed with a biomimetic sensor, J. Scheibert, S. Leurent, A. Prevost et G. Debrégeas, Science 323 1503-1506 (2009). Reviewed in Science news, Science Update (radio), Science signaling, Nature news, Nature Research highlights, Nature Methods,Analytical Chemistry, Atten. Percept & Psych.

Signatures of granular microstructure in dense shear flows. D. Mueth, G. Debregeas, G. Karczmar, P. Eng, S. Nagel & H. Jaeger,Nature 406, 385-388 (2000)

Genes Circuits Rhythms and Neuropathology

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Parkinson’s disease
dopamine
Neurodegeneration
Locomotor aging
Drosophila models

ENP label: 

2016

Research Center / Institute: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Research Unit Code: 

UMR 8249

Our research program aims at understanding how the brain controls locomotor activity, and how aging or neurodegenerative pathologies, such as Parkinson’s disease and amyotrophic lateral sclerosis, alter this function and in general brain functioning. We try to identify neuronal networks controlling locomotor activity and circadian mechanisms that modulate them in health and disease. Our approach combines genetics methods, brain imaging and behavioral assays.

Leader

Leader: 

Personal

Team members: 

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

ESPCI

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 158 3C
Laboratory

Surname: 

Laboratoire Plasticité du cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL
Publications

Publications: 

Cassar M.#, Issa A.-R.#, Riemensperger T.#, Petitgas C.#, Rival T.#, Coulom H.#, Iché-Torres M.#, Han K.-A. & Birman S#. (2015)A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T.#, Birman S.#, Stensmyr M. C. & Hansson B. S. (2014) Dopamine drivesDrosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T.#, Issa A.-R.#, Pech U., Coulom H.#, Nguy?n M.-V.#, Cassar M.#, Jacquet M.#, Fiala A. & Birman S#. (2013) Asingle dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Pech U., Pooryasin A., Birman S#. & Fiala A. (2013) Visualization of the connections between Kenyon cells and aminergic neuronsin the Drosophila melanogaster brain using split-GFP reconstitution. J. Comp. Neurol. 521(17):3992-4026

Reinhardt A., Feuillette S., Cassar M.#, Callens C.#, Thomassin H., Birman S.#, Lecourtois M., Antoniewski C. & Tricoire H. (2012)Lack of miRNA misregulation at early pathological stages in Drosophila neurodegenerative disease models. Front. Genet. 3:226