Université Paris Sud 11

Neurobiology of decision making

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

neuronal nicotinic

ENP label: 

2010

Research Unit Code: 

UMR9197

Our current projects are aimed at finding the different modulators of flexible behaviours and identifying the neural bases underlying this modularity. They involve the different members of the team:

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud 11

University: 

Université Paris Sud 11

Doctoral School: 

ED419
Laboratory

Surname: 

Département Cognition-Comportement

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

Computerized video analysis of social interactions in mice. de Chaumont F, Coura RD, Serreau P, Cressant A, Chabout J, Granon S, Olivo-Marin JC. Nat Methods. 2012 Mar 4;9(4):410-7.

Prefrontal neuromodulation by nicotinic receptors for cognitive processes. Dos Santos Coura R, Granon S. Psychopharmacology (Berl). 2012 Jan 18.

Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment. Chabout J, Serreau P, Ey E, Bellier L, Aubin T, Bourgeron T, Granon S. PLoS One. 2012;7(1):e29401. Epub 2012 Jan 6.

Granon S. & Changeux J.-P. (2011) Deciding between conflicting motivations: what mice make of their prefrontal cortex. Behav. Br. Res, Nov 18.

Besson M., David V., Cazala P., Guilloux JP, Reperant C., Cloez-Tayarani I., Changeux JP., Gardier AM., Granon S. (2011) Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. Psychopharmacology, Sep 8.

 

Development and evolution of neurotransmission

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Dopamine, hypothalamus, forebrain, neuronal plasticity, neurogenesis

ENP label: 

2007

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

Researches in the laboratory concern many fundamental aspects of brain development and evolution. The researches aim at better understand how the brains of different species develop during embryogenesis, how they are structured and organized as functional systems.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Département Développement & Évolution du cerveau

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

Affaticati P, Yamamoto K, Rizzi B, Bureau C, Peyriéras N, Pasqualini C, Demarque M, Vernier P. Identification of the optic recess region as a morphogenetic entity in the zebrafish forebrain. Sci Rep. 2015 Mar 4;5:8738. doi: 10.1038/srep08738. 

Yamamoto, K, Mirabeau, O., Bureau, C., Blin, M., Coudouel, S. and Vernier, P. (2013) Evolution of the dopamine receptor genes of the D1 class in Vertebrates. Mol. Biol. Evol. 30: 833-843

 Fontaine, R., Affaticati, P., Yamamoto, K, Jolly, C., Bureau, C, Baloche, S., Gonnet, F., Vernier, P., Dufour, S. and Pasqualini, C. (2013) Dopamine inhibits reproduction in zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Endocrinology 54: 807-18. doi: 10.1210/en.2012-1759.

Bosco A, Bureau C, Affaticati P, Gaspar P, Bally-Cuif L, Lillesaar C. (2013) Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. Development. 140: 372-84. doi: 10.1242/dev.089094.

Kalueff, AV, Stewart, AM, Kyzar, EJ, Cachat, J, Gebhardt, M., Landsman, S., Robinson, K, Maximino, C., Herculano, AM, Jesuthasan, S., Wisenden, B., Bally-Cuif, L., Lange, M., Vernier, P., Norton, W., Tierney, K., Tropepe, V., Neuhauss, SCF and the International Zebrafish Neuroscience Research Consortium. (2012) Time to recognize zebrafish ?affective? behaviour. Behaviour,149: 11019-1036

Razy-Krajka F, Brown, E., Horie, T., Callebert, J., Sasakura, Y, Joly, JS, Kusakabe, T and Vernier, P. (2012) Monoaminergic modulation of photoreception in ascidia: Evidence for a proto-hypothalamo-retinal territory. BMC Biol., 10: 45 doi:10.1186/1741-7007-10-45

Hindbrain Integrative Neurobiology

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Behaviour
Development
Breathing
Neural circuit
Rhythm generation
Mouse embryo

ENP label: 

2007

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

The intrinsic logic of neural networks controlling defined circuit functions and behaviours in the central nervous system is a fundamental issue of neuroscience. We study the central control of breathing, a classical model system to (i) perform integrative neurobiology and (ii) extend the significance of developmental biology, beyond anatomical organization to the level of network assembly and function.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Neurobiologie et Développement

Initiatives d'Excellence: 

Idex NeuroSaclay, EQUIPE X "MORPHOSCOPE 2"
Publications

Publications: 

Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O. Nature. 2013;500:85-88.

Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. Journal of Neuroscience. 2011;31:12880-8.

Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A, Fortin G. Nature Neuroscience. 2010;13:1066-74.

Thoby-Brisson M KM, Wu N, Charnay P, Champagnat J, Fortin G. Nature Neuroscience. 2009;12(8):1028-1035.

Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G. Journal of Neuroscience. 2005;25:4307-4318.

Cellular and molecular mechanisms of plasticity and memory

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Synaptic plasticity
Learning and Memory
Adult hippocampal neurogenesis
Intellectual deficiencies
Alzheimer's disease

ENP label: 

2012

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

Research in the team focuses on the cellular and molecular mechanisms of learning and memory and on identifying mechanisms responsible for memory dysfunction in brain pathologies. Our objective is to identify in different structures of the brain such as the hippocampus and cortex the cellular and molecular mechanisms underlying brain of plasticity, to characterize their role in the formation of memories and identify networks and brain structures within which these changes occur during the laying down of memories.

Leader

Leader: 

Personal

Team members: 

Sabrina Davis,Jean-Vianney Barnier, Valérie Enderlin, Roseline Poirier, Sandrine Guyon, Véronique Rousseau, Ophélie Vacca, Charlotte Castillon, Mehdi Belmaati, Kevin Duarte, Faouzi Zarrouki
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud 11

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Département Cognition & Comportements

Initiatives d'Excellence: 

Idex NeuroSaclay, contrat ANR
Publications

Publications: 

Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Enderlin E. (2014) PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments. Hippocampus, 24(11) : 1381-1393.

Vaillend C, Chaussenot R. (2017) Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin-deficient mdx mice. Hum Mol Genet, 26(6):1041-1055.

Maglorius Renkilaraj MR, Baudouin L, Wells CM, Doulazmi M, Wehrlé R, Cannaya V, Bachelin C, Barnier JV, Jia Z, Nait Oumesmar B, Dusart I, Bouslama-Oueghlani L (2017) The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation. Neurobiol Dis ; 98:137-148.

Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H, Davis S (2016) Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer’s Disease. J Alzheimers Dis.51(4):1157-1173.

Goyenvalle A, Griffith G, Babbs A, El Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJ, Davies KE, Vaillend C, Leumann C, Garcia L. (2015) Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nat Med. 21(3):270-5.

 

Metabolism, Imaging and Olfaction

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Olfactory system
neuroglial activity
Multisensory integration
imaging
food intake/obesity
electrophy/behavior

ENP label: 

2010

Research Unit Code: 

UMR 8165

What are the mechanisms underlying sensory plasticity in the adult brain? Since olfaction is the main sensory modality in rodents, we study how the olfactory system encodes and processes sensory information. We focus on the rodent’s olfactory bulb (OB), which is the structure supporting the first step of odor coding in the brain.

Personal

Team members: 

MARTIN
PAIN
Institutions

Principal Institution: 

Université Paris Diderot

Affiliated institutions: 

Université Paris Sud 11
CNRS

University: 

Université Paris Sud 11

Doctoral School: 

ED 419
Publications

Publications: 

Martin C, Ravel N. (2014) Beta and gamma oscillatory activities associated with olfactory memory tasks: different rhythms for different functional networks? Front Behav Neurosci. 8:218. Free on line.

Osmanski BF, Martin C, Montaldo G, Lanièce P, Pain F, Tanter M, Gurden H. (2014) Functional ultrasound imaging reveals different odor-evoked patterns of vascular activity in the olfactory bulb and the anterior piriform cortex. Neuroimage. 95:176-84.

Soria-Gómez E., Bellocchio L., Reguero L., Lepousez G., Martin M., Bendahmane M., Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B., Guzmán M, Gurden H., Ferreira G., Lledo PM, Grandes P., Marsicano G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience. 17(3):407-15. 

Martin C, Houitte D, Guillermier M, Petit F, Bonvento G, Gurden H. (2012) Alteration of sensory-evoked metabolic and oscillatory activities in the olfactory bulb of GLAST-deficient mice. Front Neural Circuits. 6:1. Free on line.

Cell-cell interactions in neurodegenerative diseases

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

neuron-astrocyte interactions
Mechanisms underlying region specificity in neurodegeneration
Role of reactive astrocytes

ENP label: 

2011

Research Center / Institute: 

MIRCen

Research Unit Code: 

UMR 9199

Our research focuses on the interactions between neurons and astrocytes, at the fundamental level but also in the context of neurodegenerative diseases in which glial cells display an activated phenotype that is not yet characterized at the functional level. These glial cells play an important role in brain function, particularly in energy metabolism, a function impaired in most neurodegenerative diseases (Alzheimer, Huntington and Parkinson). Our recent work shows that astrocytes activated by a cytokine (CNTF) effectively protect neurons from energy deficits (Escartin et al., 2006, 2007).

Leader

Leader: 

Institutions

Principal Institution: 

CEA

Affiliated institutions: 

CNRS

University: 

Université Paris Sud 11

Doctoral School: 

ED568 Biosigne
Laboratory

Surname: 

Laboratoire des Maladies Neurodégénératives

Initiatives d'Excellence: 

NEURATRIS
Publications

Publications: 

 Bonvento G, Valette J, Flament J, Mochel F, Brouillet E. (2017) Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases. J Cereb Blood Flow Metab. 37:1927-1943

 

Lopez-Fabuel I, Le Douce J, Logan A, James AM, Bonvento G, Murphy MP, Almeida A, Bolaños JP. (2016) Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Proc Natl Acad Sci USA 113:13063-13068

Palombo M, Ligneul C, Najac C, Le Douce J, Flament J, Escartin C, Hantraye P, Brouillet E, Bonvento G, Valette J (2016) New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo. Proc Natl Acad Sci U S A 113:6671-6676

Ben Haim L, Ceyzeriat K, Carrillo-de Sauvage MA, Aubry F, Auregan G, Guillermier M, Ruiz M, Petit F, Houitte D, Faivre E, Vandesquille M, Aron-Badin R, Dhenain M, Deglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C (2015) The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases. J Neurosci 35:2817-2829.

Boussicault L, Herard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Vega C, Bonvento G (2014) Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions. J Cereb Blood Flow Metab 34:1500-1510.

SCaNR : Stem Cells and Neurogenesis in the Retina

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Neural stem cells
Retina
Proliferation
regeneration
Signaling pathways

ENP label: 

2011

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

Our research program focuses on neural stem cells in both mice and Xenopus retina. The amphibian retina contains a population ofneural stem cells, which, in contrast to the mammalian situation, are active, allowing continuous tissue growth throughout the animallife, as well as regeneration following retinal damage.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

 

Langhe R, Chesneau A, Colozza G, Hidalgo M, Locker M and Perron M (2017). Müller glial cell reactivation in Xenopus models of retinal degeneration. Glia, 65(8):1333-1349. Hamon A, Masson C, Bitard J, Gieser L, Roger JE, and Perron M (2017). Retinal degeneration triggers the activation of YAP/TEAD in reactive Müller cells. IOVS, 58(4):1941-1953.

Schietroma C*, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel J-A, Perron M, El-Amraoui and Petit C. (2017). Shaping of the photoreceptor outer segment by the calyceal processes of the inner segment. Journal of Cell Biology, 216(6):1849-1864.

Pfirrmann T, Jandt E, Ranft S*, Lokapally A, Neuhaus H, Perron M, Hollemann T. (2016). Hh-dependent E3-Ligase Mid1 leads to ubiquitin-mediated proteasomal degradation of Pax6 protein from the forming optic stalk. PNAS 113(36):10103-8.

Cabochette P, Vega-Lopez G, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O, Perron M (2015). YAP controls retinal stem cell DNA replication timing and genomic stability. eLife 4:e08488.

Neuroimaging of Human Cognitive Architectures

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

language
Functional imaging
cognition
calculation
consciousness

ENP label: 

2007

Research Center / Institute: 

Neurospin

Research Unit Code: 

U992

Study of fine-grained cognitive representations and processes underlying cognition and perception; of contrast between conscious and non-conscious operations, to identify signatures of conscious level processing.

 Analyze the impact of education on the adult brain organization for reading and arithmetic.

 Study the development of language and consciousness in human infants and young children and human adult architecture for sentence-level processing of language.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Philippe Pinel
SCHURGER Aaron
MEYNIEL Florent
MARTI Sébastien
NELSON Matthew
HANNAGHAN Thomas
MOUTARD Clement
AMALRIC Marie
PINHEIRO CHAGAS Pedro
MAHEU Maxime
TROVO Bianca
POTIER WATKINS Cassandra
SANTORO Giovanna
LABRUNA Laurence
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Collège de France
CEA

University: 

Université Paris Sud 11

Doctoral School: 

ED419 - ED158
Laboratory

Surname: 

Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

Idex Neuro Saclay, ERC Advanced "NeuroSyntax"
Publications

Publications: 

 

Amalric, M., & Dehaene, S. (2016). Origins of the brain networks for advanced mathematics in expert mathematicians. Proceedings of the National Academy of Sciences, 201603205. https://doi.org/10.1073/pnas.1603205113

Meyniel, F., & Dehaene, S. (2017). Brain networks for confidence weighting and hierarchical inference during probabilistic learning. Proceedings of the National Academy of Sciences of the United States of America, 114(19), E3859–E3868. https://doi.org/10.1073/pnas.1615773114

Meyniel, F., Maheu, M., & Dehaene, S. (2016). Human Inferences about Sequences: A Minimal Transition Probability Model. PLoS Computational Biology, 12(12), e1005260. https://doi.org/10.1371/journal.pcbi.1005260

Nelson, M. J., El Karoui, I., Giber, K., Yang, X., Cohen, L., Koopman, H., … Dehaene, S. (2017). Neurophysiological dynamics of phrase-structure building during sentence processing. Proceedings of the National Academy of Sciences of the United States of America, 114(18), E3669–E3678. https://doi.org/10.1073/pnas.1701590114

Trübutschek, D., Marti, S., Ojeda, A., King, J.-R., Mi, Y., Tsodyks, M., & Dehaene, S. (2017). A theory of working memory without consciousness or sustained activity. eLife, 6. https://doi.org/10.7554/eLife.23871