Research Director
ED 158


Our goal is to understand how a sensory stimulus such as an odor generates a population activity in a small cellular network, the olfactory bulb glomerulus. We investigate this question by using or...


Curriculum vitae

NAME: Charpak Serge

ADDRESS: Institut de la Vision, 17 rue Moreau, 75012 Paris

DATE OF BIRTH: 03/12/58


TEL: 33 (0)1 42 86 41 48

FAX: 33 (0)1 42 86 41 51




1991                 D.Phil., Paris 6. Slow glutamatergic synaptic transmission in the CNS: role of metabotropic receptors.

1987                 M.D., Paris 6. Opiate inhibition of the ventromedial nucleus of the hypothalamus.


2004-present     Director of the Laboratory of Neurophysiology and New Microscopies, recognized by the Inserm (as Unit 603) and the CNRS (Physics department, as Unit 8154), at the University Paris Descartes, Paris, France.

2000-2004         Director of the Laboratory of Neurophysiology and New Microscopies, recognized by the Inserm (DR1) and the CNRS, at the ESCPI, Paris, France.

1995-2003         Full Professor of Neurophysiology, ESPCI, Paris, France.

1993-1995        Assistant-Professor, University Medical Center, Geneva, Switzerland.   

1991-1993         Research Fellow (R. Llinas) New York University, U.S.A.

1988-1991         Assistant (B. Gähwiler) Brain Research Institute, Zurich, Switzerland.

1985-1988        Assistant (JJ Dreifuss) Umniversity Medical Center, Geneva, Switzerland.


2009-present     In charge of the teaching session on “electrophysiology and cellular imaging” from the Master 2 of Neurobiology at the University Paris Descartes.

1995-2003        In charge of the Neurophysiology course at the ESPCI.


2000-present     Direction of the Laboratory of Neurophysiology and New Microscopies.

2012-present     Member of the DIM “Brain and Though” Scientific Council..

2009-present     Member of the UFR Biomédicale Scientific Council..

2007-present     Member of the Paris School of Neuroscience Scientific Council.


10 recent publications:

-Parpaleix A, Houssen YG, Charpak S.(2013) Imaging local neuronal activity by monitoring Po2 transients in capillaries. Nature med, 19:241-246

-Lecoq, J, Parpaleix, A, Roussakis, E, Ducros, M., Goulam, Y, Vinogradov, S, Charpak, S (2011) Simultaneous two-photon imaging of oxygen and bloodflow in deep cerebral vessels. Nature Med. 17: 893-898.

-Najac M., De Saintjan D,Reguero L,Grandes P,Charpak S (2011) Mono- and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons, J Neurosci. 31:8722-8729

-Attwell, D., Buchan, A.M., Charpak, S., Lauritzen, M., Macvicar, B.A. & Newman, E.A. (2010) Glial and neuronal control of brain blood flow. Nature 468, 232-243. (Review)

-Lecoq J, Tiret P, Charpak S (2009) Peripheral adaptation codes for high odor concentration in glomeruli. J Neurosci 29:3067-3072.

-Lecoq J, Tiret P, Najac M, Shepherd GM, Greer CA, Charpak S (2009) Odor-evoked oxygen consumption by action potential and synaptic transmission in the olfactory bulb. J Neurosci 29:1424-1433.

-Chaigneau E, Tiret P, Lecoq J, Ducros M, Knopfel T, Charpak S (2007) The relationship between blood flow and neuronal activity in the rodent olfactory bulb. J Neurosci 27:6452-6460.

-Kozlov AS, Angulo MC, Audinat E,  Charpak S (2006) Target cell-specific modulation of neuronal activity by astrocytes. Proc Natl Acad Sci U S A 103:10058-10063.

-Chaigneau E, Oheim M, Audinat E, Charpak  S (2003) Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. Proc Natl Acad Sci U S A 100: 13081-13086.

-Leobon B, Garcin I, Menasche P, Vilquin JT, Audinat E, Charpak S (2003) Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci U S A 100: 7808-7811.