Title:
MrSurname:
GASNIERName:
BrunoBiography/CV:
CURRENT SITUATION
CNRS Research Director
Group Leader at CNRS/Paris Descartes UMR 8192, 45 rue des Saints-Pères, 75006 Paris
Jan. 14: Deputy Director of CNRS/Paris Descartes UMR ?Neurophotonics? with V. Emiliani
EDUCATION
1980- 1985 Ecole Normale Supérieure, Paris
1985 PhD in Cellular and Molecular Pharmacology; Paris 6 University
PROFESSIONAL EXPERIENCE
1986-1987 Postdoc at the Gulbenkian Institute of Science, Oeiras, Portugal
1988-2001 CNRS scientist
1994-2010 Group leader at the Institut de Biologie Physico-Chimique
2002- CNRS research director
2005-2008 Head of the CNRS research unit UPR 1929
2009-2013 Group leader at CNRS/Paris Descartes ?Membrane dynamics? unit (UMR 8192)
2014- Deputy Director with V. Emiliani of CNRS/Paris Descartes ?Neurophotonics? unit
Team leader at Saints-Peres Paris Institute for the Neurosciences
PUBLICATIONS AND PATENTS
51 publications in journals with review committee, 3 book chapters, 1 patent
Number of citations: 2517
h-index : 28
5 SELECTED PUBLICATIONS
Sagné C., El Mestikawy S., Isambert M.F., Hamon M., Henry J.P., Giros B. & Gasnier B. (1997) Cloning of a functional vesicular
GABA and glycine transporter by screening of genome databases. FEBS Letters 417, 177-183
Morin, P., Sagné, C. & Gasnier, B. (2004) Functional characterization of wild-type and mutant human sialin. EMBO Journal 23,
4560-4570
Aubrey, K.R., Rossi, F.M., Ruivo, R., Alboni, S., Bellenchi, G.C., Le Goff, A., Gasnier*, B. Supplisson*, S. (2007) The transporters
GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype. J. Neurosci. 27, 6273-6281. (*co-senior authors)
Ruivo R., Bellenchi G.C., Chen X., Zifarelli G., Sagné C., Debacker C., Pusch M., Supplisson S., Gasnier B. (2012) Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Proc. Natl. Acad. Sci. USA 109, E210-E217.
Jézégou, A., Llinares, E., Anne, C., Kieffer-Jaquinod, S., O?Regan, S., Aupetit, J., Chabli, A., Sagné, C., Debacker, C.,
Chadefaux-Vekemans, B., Journet, A., André, B., Gasnier, B. (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid
exporter underlying the action of cysteamine in cystinosis therapy. Proc. Natl. Acad. Sci. USA 109, E3434?E3443
INVITED ORAL PRESENTATIONS
24 invited talks in international meetings
33 invited seminars in Europe, USA, India and China
5 SELECTED INVITED CONFERENCES
12th International Congress on Neuronal Ceroid Lipofuscinoses, Hamburg, Germany 3-6/6/2009
Gordon Research Conference on Lysosomal Diseases, Galveston TX, USA 23-28/1/2011; session chair
Satellite meeting ?Vesicular transporters? of the 8th FENS Forum of Neurosciences, Barcelona, Spain 13/7/2012
10th National Neuronal Ceroid Lipofuscinosis (NCL) Foundation Congress, Hamburg, Germany, 3/12/2012
Gordon Research Conference on Mechanisms of Membrane Transport, Mount Holyoke College, South Hadley MA, 16-21/6/2013
19th European Study Group on Lysosomal Diseases Workshop, Leibnitz, Austria, 25-29/9/2013
RECENT GRANTS
ANR (2005-7, coordinator; 2009-11, partner); Batten Disease Support & Research Association (BDSRA) USA (2011, PI); Cystinosis
Research Foundation USA (2007-9, coordinator; 2010-12, coordinator; 2012-14, coordinator); Fédération pour la Recherche sur le
Cerveau (2008, partner); Fondation Louis D (2010, partner); Paris Descartes in-house interdisciplinary grants (2011, coordinator);
Vaincre les Maladies Lysosomales (2010, PI; 2013, PI)
COLLECTIVE RESPONSIBILITIES
Teaching in several Neuroscience Masters (~20 h/year at Paris Descartes; Paris Curie; and Paris Sud)
Supervision of 7 PhD thesis; Reviewer/examinator of 21 theses
Grant review for NSF, BBSRC, FNRS Belgium, HRB Ireland, Czech Science Foundation, etc
MEMBERSHIPS
ASBMB ; Biophysical Society ; Société des Neurosciences
Scientific advisory board of ?Vaincre les Maladies Lysosomales?