Impact of Alzheimer's disease related nucleation propagation mechanisms on functional connectivity
Dates:January 2, 2018 - June 29, 2018
Application deadline:June 29, 2018
~ Jan-March 2018
~ April-June 2018
The project we propose concerns the evaluation of new mechanisms involved in Alzheimer's disease (AD). We focus on nucleation/propagation hypothesis which suggests that poorly-shaped forms (pathological) of amyloid and tau proteins can transmit their misfolded forms to normal proteins and induce pathology. We seek to understand the reality of these mechanisms in rodents and primates and what are the functional consequences of nucleation/propagation processes on neuronal networks (assessed by MRI with resting-state fMRI).
MIRCen - 18, route du Panorama 92260 Fontenay aux Roses - +33 1 46 54 81 92 - Marc.Dhenain@cea.fr