Schizophrénie

CELLULAR MECHANISMS OF NEUROTRANSMISSION

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Depression
schizophrenia
psychiatry

ENP label: 

2014

Research Unit Code: 

UMR 894

Le projet de l'équipe est d’identifier de nouvelles protéines et de nouveaux mécanismes impliqués dans le trafic neuronal de récepteurs, dans le but de caractériser de nouvelles cibles thérapeutiques dans le domaine de la dépression, la schizophrénie et d’autres pathologies neuronales et psychiatriques.

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris Descartes

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Publications

Publications: 

Al Awabdh Sana , ? Masson J., Hamon M., Emerit M.B., Darmon M. J Neurosci. 2012 32(41):14227-14241.

Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24

M. Humbert-Claude, E. Davenas, F. Gbahou, L. Vincent and J. M. Arrang: Psychopharmacology (Berl). 2012;220(1):225-41.

F. Gbahou, A. Rouleau and J. M. Arrang: Br J Pharmacol. 2012 166(6):1860-71.

M. El Hage, J. Masson, A. Conjard-Duplany, B. Ferrier, G. Baverel and G. Martin: J Cereb Blood Flow Metab. 2012.

Psychiatry genetic

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
Schizophrénie
autisme
psychiatrie
biologie moléculaire
imagerie
Stress
Psychose
Bipolaire

ENP label: 

2007

Research Center / Institute: 

IMRB -Institut Mondor de Recherche Biomédicale

Research Unit Code: 

U955

Our research efforts have contributed to a better identification of relevant phenotype for genetic studies, particularly on the field of bipolar disorder, schizophrenia, suicide, autism, OCD and pharmaco-genetic studies. Being principal investigator of national and international groups, she has been able to produce prominent findings such as identification in autism of the first mutations in neuroligins (NLGN-3 and NLGN-4).

Leader

Leader: 

Co leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris-Est Créteil
Publications

Publications: 

 

Houenou J, Boisgontier J, Henrion A, d'Albis MA, Dumaine A, Linke J, Wessa M, Daban C, Hamdani N, Delavest M, Llorca PM, Lançon C, Schürhoff F, Szöke A, Le Corvoisier P, Barau C, Poupon C, Etain B, Leboyer M, Jamain S. A multi-level functional study of a SNAP25 at-risk variant for bipolar disorder and schizophrenia. J Neurosci. in press. 

Leboyer M, Berk M, Yolken RH, Tamouza R, Kupfer D, Groc L. Immuno-psychiatry: an agenda for clinical practice and innovative research. 2016. BMC Med, 14: 173. 

Pignon B, Schürhoff F, Baudin G, Ferchiou A, Richard JR, Saba G, Leboyer M, Kirkbride JB, Szöke A.  Spatial distribution of psychotic disorders in an urban area of France: an ecological study. 2016. Sci Rep, 6: 26190.

Sakae DY, Marti F, Lecca S, Vorspan F, Martín-García E, Morel LJ, Henrion A, Gutiérrez-Cuesta J, Besnard A, Heck N, Herzog E, Bolte S, Prado VF, Prado MA, Bellivier F, Eap CB, Crettol S, Vanhoutte P, Caboche J, Gratton A, Moquin L, Giros B, Maldonado R, Daumas S, Mameli M, Jamain S, El Mestikawy S. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. 2015. Mol Psychiatry, 20: 1448-59.

Sarrazin S, Poupon C, Linke J, Wessa M, Phillips M, Delavest M, Versace A, Almeida J, Guevara P, Duclap D, Duchesnay E, Mangin JF, Le Dudal K, Daban C, Hamdani N, D'Albis MA, Leboyer M, Houenou J. A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity. 2014. JAMA Psychiatry, 71: 388-96.

Imaging and Psychiatry

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
schizophrenia
autism
Brain imaging
addiction

ENP label: 

2012

Research Center / Institute: 

Imagen Orsay Service Hospitalier Frédéric Joliot

Research Unit Code: 

U1000

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CEA

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

ED158
Laboratory

Surname: 

Laboratoire Imagerie et Psychiatrie

Initiatives d'Excellence: 

IHU Necker
Publications

Publications: 

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192