schizophrenia

CELLULAR MECHANISMS OF NEUROTRANSMISSION

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Depression
schizophrenia
psychiatry

ENP label: 

2014

Research Unit Code: 

UMR 894

Le projet de l'équipe est d’identifier de nouvelles protéines et de nouveaux mécanismes impliqués dans le trafic neuronal de récepteurs, dans le but de caractériser de nouvelles cibles thérapeutiques dans le domaine de la dépression, la schizophrénie et d’autres pathologies neuronales et psychiatriques.

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris Descartes

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Publications

Publications: 

Al Awabdh Sana , ? Masson J., Hamon M., Emerit M.B., Darmon M. J Neurosci. 2012 32(41):14227-14241.

Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24

M. Humbert-Claude, E. Davenas, F. Gbahou, L. Vincent and J. M. Arrang: Psychopharmacology (Berl). 2012;220(1):225-41.

F. Gbahou, A. Rouleau and J. M. Arrang: Br J Pharmacol. 2012 166(6):1860-71.

M. El Hage, J. Masson, A. Conjard-Duplany, B. Ferrier, G. Baverel and G. Martin: J Cereb Blood Flow Metab. 2012.

Cellular Integration of Neuromodulatory Processes

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

biosensor imaging
striatum
dopamine
Parkinson
schizophrenia

ENP label: 

2014

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

UMR 8256

Mesencephalic dopaminergic neurons project towards various brain regions, including the striatum and the prefrontal cortex.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Biological Adaptation and Ageing
Publications

Publications: 

Yapo, C., Nair, A.G., Clement, L., Castro, L.R. et al., Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. J Physiol. 2017, in press, 

Castro, L.R., Brito, M., Guiot, E., Polito, M. et al., Striatal neurones have a specific ability to respond to phasic dopamine release. J Physiol. 2013, 591, 3197-3214.

Castro, L.R., Guiot, E., Polito, M., Paupardin-Tritsch, D. et al., Decoding spatial and temporal features of neuronal cAMP/PKA signaling with FRET biosensors. Biotechnol J. 2014, 9, 192-202.

Polito, M., Guiot, E., Gangarossa, G., Longueville, S. et al., Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32. eNeuro. 2015, 2, 1-15.

Nair, A.G., Gutierrez-Arenas, O., Eriksson, O., Vincent, P. et al., Sensing Positive versus Negative Reward Signals through Adenylyl Cyclase-Coupled GPCRs in Direct and Indirect Pathway Striatal Medium Spiny Neurons. J Neurosci. 2015, 35, 14017-14030.

Physiopathology of psychiatric diseases

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
schizophrenia
animal models
Interindividual Vulnerability
Integrated studies

ENP label: 

2012

Research Unit Code: 

U1130 UMR8246 UMCR18

 Our team carries out preclinical studies to better understand psychiatric diseases and to discover innovative therapies. We develop animal models and characterize synaptic targets which play a role in neurotransmission (mostly neurotransmitter transporters). This work is also carried out in humans using genetic and anatomical approaches, specifically focusing on autism and mental retardation.



Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie
Laboratory

Surname: 

Neuroscience Paris Seine
Publications

Publications: 

Bacq A, Balasse L, Biala G, Guiard B, Gardier AM, Schinkel A, Louis F, Vialou V, Martres MP, Chevarin C, Hamon M, Giros B, Gautron S. Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response. Mol Psychiatry 2012;17(9):926-939.

Baudin A, Blot K, Verney C, Estevez L, Santa-Maria J, Gressens P, Giros B, Otani S, Dauge V, Naudon L. Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex.Neurobiol Learn Mem 2012.

Berthet A, Bezard E, Porras G, Fasano S, Barroso-Chinea P, Dehay B, Martinez A, Thiolat ML, Nosten-Bertrand M, Giros B,Baufreton J, Li Q, Bloch B, Martin-Negrier ML. L-DOPA impairs proteasome activity in parkinsonism through D1 dopamine receptor. J Neurosci 2012;32(2):681-691.

El Khoury MA, Gorgievski V, Moutsimilli L, Giros B, Tzavara ET. Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies. Prog Neuropsychopharmacol Biol Psychiatry 2012;38(1):36-50.

Farley S, Dumas S, El Mestikawy S, Giros B. Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801.
Neuropharmacology 2012;62(1):503-517.

Imaging and Psychiatry

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
schizophrenia
autism
Brain imaging
addiction

ENP label: 

2012

Research Center / Institute: 

Imagen Orsay Service Hospitalier Frédéric Joliot

Research Unit Code: 

U1000

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CEA

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

ED158
Laboratory

Surname: 

Laboratoire Imagerie et Psychiatrie

Initiatives d'Excellence: 

IHU Necker
Publications

Publications: 

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192