post-lesion repair

Brain development, repair and ageing

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Alzheimer's disease
synaptic development
post-lesion repair
non-invasive brain stimulation

ENP label: 

2015

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

UMR8256

BDRA studies mechanisms underlying the development, repair and ageing of the brain, using cerebellar and hippocampal models in vivo and in vitro, to address fundamental biological bases of these phenomena and to explore clinical applications.

The team’s multidisciplinary approach, from molecules to behavior and bench to the clinic, expands the Unit’s research fields into the evolution of accumulating synaptic dysfunction with time and the potential for its repair.

Leader

Leader: 

Co leader: 

Institutions

Principal Institution: 

UPMC

Affiliated institutions: 

CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED3C 158
Laboratory

Surname: 

Biological Adaptation and Ageing

Initiatives d'Excellence: 

LabEx Biopsy, Udex Super de l'UPMC, DHU FAST
Publications

Publications: 

Grehl S, Martina D, Goyenvalle C, Deng ZD, Rodger J, Sherrard RM. In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields. Front Neural Circuits. 2016 Nov 3;10:85. 

Vernet-der Garabedian B#, Derer P#, Bailly Y, Mariani J# (2013) Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum J Neuroinflamm.;10:65.

Chen XR Heck N Lohof AM# Rochefort C Morel MP Wehrle R Doulazmi M# Marty S Cannaya V Avci HX# Mariani J# Rondi-Reig L Vodjdani G Sherrard RM# Sotelo C Dusart I (2013) Mature Purkinje cells require RORalpha to maintain climbing fiber mono-innervation and other adult characteristics. J Neurosci. 33(22):9546-62.

Makowiecki K, Harvey AR, Sherrard RM#, Rodger J (2014) Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice. J Neurosci 34:10780-10792

Grehl S#, Viola H, Fuller-Carter PI, Carter KW, Dunlop SA, Hool L, Sherrard RM*#, Rodger J*# (2015) Cellular and molecular changes to cortical neurons following low intensity repetitive magnetic stimulation at different frequencies. Brain Stim 8:114-123 *=co-senior

Cifuentes D, Poittevin M, Dere E#, Broqueres-You, D, Bonnin P, Benessiano J, Pocard M, Mariani J#, Kubis N, Merkulova-Rainon T, Lévy B (2014) Hypertension accelerates the progression of Alzheimer-Like pathology in a mouse model of the disease. Hypertension, (Oct 20)