Nucleation/propagation

Alzheimer's Disease and brain aging: Multimodal imaging and therapy

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Alzheimer
imaging
therapy
Nucleation/propagation
Translational research

ENP label: 

2016

Research Center / Institute: 

MIRCen

Research Unit Code: 

UMR 9199

Alzheimer's disease (AD) is a public health problem in our societies. It is associated with the intracerebral accumulation of amyloid plaques and tau lesions. Our team tackles this disease by focusing on three different points. 

Leader

Leader: 

Personal

Team members: 

Thierry Delzescaux
Fanny Petit
Jean-Luc Picq
Anne Sophie Herard
Nicolas Souedet
Nachiket Nadkarni
Cedric Clouchoux
Charlotte Gary
Yael Balbastre
Zhenzhen You
Clement Garin
Clemence Dudeffant
Clement Bouvier
Emmalaurie Baptiste
Lisa Ciaptacz
Institutions

Principal Institution: 

Mircen

Affiliated institutions: 

CNRS
CEA
Université Paris Sud
Université Paris Saclay

Doctoral School: 

ED568 - Biosigne
Laboratory

Surname: 

Laboratoire des Maladies Neurodégénératives

Initiatives d'Excellence: 

Neuratris
Publications

Publications: 

Vandenberghe M., Hérard A.S., Souedet N., Sadouni E., Santin M., Briet D., Carré D., Schultz J., Hantraye P., Chabrier P.E., Rooney T., Debeir T., Blanchard V., Pradier L., Dhenain M., Delzescaux T.. Brain-wide quantitative histopathology in mice at the mesoscopic scale. Scientific Reports. 2016, 6:20958 | DOI: 10.1038/srep20958.

Dudeffant C.*, Vandesquille M.*, Herbert K., Garin C. M., Alves S., Comoy E., Petit F., Dhenain M. Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer's disease brains. Scientific Reports. 2017;7(1):4955.

Vandesquille M.§, Li T.F.§, Po C., Ganneau C., Lenormand P., Dudeffant C., Czech C., Grueninger F., Duyckaerts C., Delatour B., Dhenain M.*, Lafaye P.*, Bay S.. Chemically-defined gadolinium - single-domain antibody conjugate: a nanoimaging agent for the diagnosis of Alzheimer’s disease. mAbs. 2017;9(6):1016-27.

Djelti F., Dhenain M., Terrien J.L., Picq J.L., Hardy I., Champeval D., Perret M., Schenker E., Epelbaum J, Aujard F. High Fasting Blood Glucose is an index of early cognitive impairment and hippocampus and-septum atrophy in middle-aged non-human primates. Aging Aging (Albany NY). 2017; 9 (1), 173-186.

Santin M.D., Vandenberghe M., Herard A.S., Pradier L., Cohen C., Debeir T., Delzescaux T., Rooney T., Dhenain M.. In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-Aβ antibody in transgenic mice. Frontiers in Aging Neuroscience. 2016, 22 March 2016 http://dx.doi.org/10.3389/fnagi.2016.00055.