Neural stem cells, Retina, Signaling pathways, Proliferation, Regeneration

SCaNR : Stem Cells and Neurogenesis in the Retina

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Neural stem cells
Retina
Proliferation
regeneration
Signaling pathways

ENP label: 

2011

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

Our research program focuses on neural stem cells in both mice and Xenopus retina. The amphibian retina contains a population ofneural stem cells, which, in contrast to the mammalian situation, are active, allowing continuous tissue growth throughout the animallife, as well as regeneration following retinal damage.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

University: 

Université Paris Sud 11

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

 

Langhe R, Chesneau A, Colozza G, Hidalgo M, Locker M and Perron M (2017). Müller glial cell reactivation in Xenopus models of retinal degeneration. Glia, 65(8):1333-1349. Hamon A, Masson C, Bitard J, Gieser L, Roger JE, and Perron M (2017). Retinal degeneration triggers the activation of YAP/TEAD in reactive Müller cells. IOVS, 58(4):1941-1953.

Schietroma C*, Parain K, Estivalet A, Aghaie A, Boutet de Monvel J, Picaud S, Sahel J-A, Perron M, El-Amraoui and Petit C. (2017). Shaping of the photoreceptor outer segment by the calyceal processes of the inner segment. Journal of Cell Biology, 216(6):1849-1864.

Pfirrmann T, Jandt E, Ranft S*, Lokapally A, Neuhaus H, Perron M, Hollemann T. (2016). Hh-dependent E3-Ligase Mid1 leads to ubiquitin-mediated proteasomal degradation of Pax6 protein from the forming optic stalk. PNAS 113(36):10103-8.

Cabochette P, Vega-Lopez G, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, Locker M, Bronchain O, Perron M (2015). YAP controls retinal stem cell DNA replication timing and genomic stability. eLife 4:e08488.