myelin

Cellular and Molecular approaches of Myelin repair

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

myelin
myelination
repair
Multiple Sclerosis

ENP label: 

2007

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The team is based on two PIs, Anne Baron-Van Evercooren and Brahim Nait Oumesmar, who share a common interest in understanding how remyelination proceeds and how it can be promoted with a strong emphasis on remyelinating cells and animal models of demyelination. They have, however, their independent lines of investigations.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU A-ICM, Neuratris, Grant of the Progressive MS Alliance (BraveinMS)
Publications

Publications: 

Blanchard B, Heurtaux T, Garcia C, Moll NM, Caillava C, Grandbarbe L, Klosptein A, Kerninon C, Frah M, Coowar D, Baron-Van Evercooren A, Morga E, Heuschling P, Nait Oumesmar B (2013) Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis. J Neurosci 33(28):11633-42.

El Behi M#, Sanson C#, Bachelin C, Guillot-Noël L, Fransson J, Stankoff B, Maillart E, Sarrazin N, Guillemot V, Abdi H, Cournu-Rebeix I*, Fontaine B*, Zujovic V* (2017) Adaptive human immunity drives remyelination in a mouse model of demyelination. Brain 140(4):967-980.

Mozafari S, Laterza C, Roussel D, Bachelin C, Marteyn A, Deboux C, Martino G, Baron-Van Evercooren A (2015) Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice. J Clin Invest 125(9):3642-56.

Wegener A, Deboux C, Bachelin C, Frah M, Kerninon C, Seilhean D, Weider M, Wegner M, Nait-Oumesmar B (2015) Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination. Brain 138(Pt 1):120-35.

Moll NM, Hong E, Fauveau M, Naruse M, Kerninon C, Tepavcevic V, Klopstein A, Seilhean D, Chew LJ, Gallo V, Nait Oumesmar B (2013) SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis. Glia 61(10):1659-72.