mouse genetics

Membrane Traffic in Healthy & Diseased Brain

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

mouse genetics
Exocytosis
SNARE
Biophysics
Microscopy

ENP label: 

2007

Research Center / Institute: 

Institut de Psychiatrie et Neurosciences de Paris, IPNP (ex-CPN) - Centre Hospitalier Sainte Anne

Research Unit Code: 

UMRS 894

Membrane trafficking allows for the communication between the different membrane compartments of the biosynthetic and endocytic pathways and for the communication between cells and their environment through the secretion of signalling molecules by exocytosis and capture of nutrients by endocytosis. Exocytosis and endocytosis are crucial to maintain cell homeostasis and are also involved in differentiation and morphogenesis of cells.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Thierry Galli, DR1 INSERM, DU
Christian Vannier, DR2 INSERM
Lydia Danglot, CR1 INSERM
David Tareste, CR1 INSERM
Sébastien Nola, IR2 INSERM
Agathe Verraes, TCS CNRS
Jose Wojnacki, Postdoc
Guan Wang, doc.
Ahmed Zahraoui, DR CNRS
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Sainte Anne

University: 

Université Paris Descartes
Laboratory

Initiatives d'Excellence: 

Labex ‘WhoAmI ?’ Investissement d’Avenir, Plateforme Distribuée ‘FranceBioImaging-FBI’
Publications

Publications: 

Petkovic M, Jemaiel A, Daste F, Specht CG, Izeddin I, Vorkel D, Verbavatz JM, Darzacq X, Triller A, Pfenninger KH, Tareste D, Jackson CL, Galli T. The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion. Nat Cell Biol. 2014 May;16(5):434-44. doi: 10.1038/ncb2937. Epub 2014 Apr 6.

Larghi P, Williamson DJ, Carpier JM, Dogniaux S, Chemin K, Bohineust A, Danglot L, Gaus K, Galli T§, Hivroz C§. (2013) VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol. doi:10.1038/ni.2609. § co-senior authors. (F1000)

Burgo A., Proux-Gillardeaux, V., Sotirakis, E., Bun, P., Casano,A., Verraes, A., Liem, R., Formstecher, E., Coppey, M. Galli, T. (2012). A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Developmental Cell,23:166?180.

Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T. (2012). The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion. J Cell Biol 196:37-46. (F1000)

Danglot L*, Zylbersztejn K*, Petkovic M*, Meziane H, Combe R, Champy Mf, Birling Mc, Pavlovic G, Bizot Jc, Trovero F, Della Ragione F, Proux-Gillardeaux V, Sorg T, D?esposito M, Galli T. (2012). Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice. J Neurosci 32:1962-1968 (F1000)

Danglot L, Chaineau M, Dahan M, Gendron M-C, Boggetto N, Perez F, and Galli T. (2010). Role of TI-VAMP and CD82 in EGF receptor cell surface dynamics and signaling. J Cell Sci 123:723-35.

Neural Circuits and Behaviour

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

behavior
Olfactory processing
mouse genetics
imaging

ENP label: 

2011

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR7241 U1050

My laboratory is interested in the functional properties of neural circuits underlying odor perception. We use a combination of molecular genetic, in vivo imaging and behavioral approaches in mice to understand the logic of odor coding in higher olfactory centers in the cortex.

Leader

Leader: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

Labex MemoLife
Publications

Publications: 

Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi GB,Fleischmann A. Molecular signatures of neural connectivity in the olfactory cortex. Nat Commun. 2016 Jul 18;7:12238. doi: 10.1038/ncomms12238.

Fleischmann A, Abdus-Saboor I, Sayed A, Shykind B (2013) Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. PLoS Biol 11(5): e1001568. doi:10.1371/journal.pbio.1001568 

K. Angelo, D. Pimentel, B. Pichler, A. Fleischmann, E. Rancz & T. Margrie , A biophysical signature of network affiliation and sensory processing in mitral cells. Nature, Aug16;488(7411):375-8.(2012)

Glinka M.E., Samuels B.A., Teillon J., Mei D.F., Shykind B.M., Hen R. & Fleischmann A., Olfactory deficits cause anxiety-like behaviors in mice. J. Neurosci., 32(19):6718-6725 (2012)

Choi G.B., Stettler D.D., Kallman B.R., Bhaskar S.T., Fleischmann A. & Axel R. (2011), Driving opposing behaviors with ensembles of piriform neurons. Cell146:1004-1015

Fleischmann A., Shykind B.M., Sosulski D.L., Franks K.M, Glinka M.E., Mei D.F., Yonghua S., Kirkland J., Mendelsohn M., Albers M.W. & Axel R., Mice with a "monoclonal" nose: perturbations in an olfactory map impair odor discrimination.Neuron. Dec 26; (60):1-14.  (2008)

Fleischmann A., Jochum W., Eferl R., Witowsky J. & Wagner E.F., Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell.Dec;4(6):477-82. (2003)