Mechanisms underlying region specificity in neurodegeneration

Cell-cell interactions in neurodegenerative diseases

Main field of research: 

Neurological and psychiatric diseases


neuron-astrocyte interactions
Mechanisms underlying region specificity in neurodegeneration
Role of reactive astrocytes

ENP label: 


Research Center / Institute: 


Research Unit Code: 

UMR 9199

Our research focuses on the interactions between neurons and astrocytes, at the fundamental level but also in the context of neurodegenerative diseases in which glial cells display an activated phenotype that is not yet characterized at the functional level. These glial cells play an important role in brain function, particularly in energy metabolism, a function impaired in most neurodegenerative diseases (Alzheimer, Huntington and Parkinson). Our recent work shows that astrocytes activated by a cytokine (CNTF) effectively protect neurons from energy deficits (Escartin et al., 2006, 2007).




Principal Institution: 


Affiliated institutions: 



Université Paris Sud 11

Doctoral School: 

ED568 Biosigne


Laboratoire des Maladies Neurodégénératives

Initiatives d'Excellence: 



 Bonvento G, Valette J, Flament J, Mochel F, Brouillet E. (2017) Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases. J Cereb Blood Flow Metab. 37:1927-1943


Lopez-Fabuel I, Le Douce J, Logan A, James AM, Bonvento G, Murphy MP, Almeida A, Bolaños JP. (2016) Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Proc Natl Acad Sci USA 113:13063-13068

Palombo M, Ligneul C, Najac C, Le Douce J, Flament J, Escartin C, Hantraye P, Brouillet E, Bonvento G, Valette J (2016) New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo. Proc Natl Acad Sci U S A 113:6671-6676

Ben Haim L, Ceyzeriat K, Carrillo-de Sauvage MA, Aubry F, Auregan G, Guillermier M, Ruiz M, Petit F, Houitte D, Faivre E, Vandesquille M, Aron-Badin R, Dhenain M, Deglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C (2015) The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases. J Neurosci 35:2817-2829.

Boussicault L, Herard AS, Calingasan N, Petit F, Malgorn C, Merienne N, Jan C, Gaillard MC, Lerchundi R, Barros LF, Escartin C, Delzescaux T, Mariani J, Hantraye P, Beal MF, Brouillet E, Vega C, Bonvento G (2014) Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions. J Cereb Blood Flow Metab 34:1500-1510.