Interactions neurone-glie

Neuroglial Interactions in Cerebral Physiopathology

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

astrocytes
neuroglial

ENP label: 

2011

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR7241 - U1050

The main goal of our group is to determine whether and how astrocytes play an active and direct role in information processing. We want to unravel the molecular modalities and functional outcomes of neuroglial interactions in physiological and pathological conditions. More precisely, we want to understand how neurons and glia communicate in various regimes of activity and determine the outcome of disrupting their communication on neuronal functions, including their excitability, synaptic transmission, plasticity and synchronization.

Leader

Leader: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

Labex Memolife, ERC 2016
Publications

Publications: 

 

Dallérac, G., Rouach, N., 2016. Astrocytes as new targets to improve cognitive functions. Prog. Neurobiol.

Chever, O., Dossi, E., Pannasch, U., Derangeon, M., Rouach, N., 2016. Astroglial networks promote neuronal coordination. Sci Signal 9, ra6.

Pannasch, U., Freche, D., Dallérac, G., Ghézali, G., Escartin, C., Ezan, P., Cohen-Salmon, M., Benchenane, K., Abudara, V., Dufour, A., Lübke, J.H.R., Déglon, N., Knott, G., Holcman, D., Rouach, N., 2014. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat. Neurosci. 17, 549–558.

Chever, O., Lee, C.-Y., Rouach, N., 2014. Astroglial connexin43 hemichannels tune Basal excitatory synaptic transmission. J. Neurosci. 34, 11228–11232.

Pannasch, U., Rouach, N., 2013. Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci. Volume 36, Issue 7, July, 405–417.