Epilepsie

Neuroglial Interactions in Cerebral Physiopathology

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

astrocytes
neuroglial

ENP label: 

2011

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR7241 - U1050

The main goal of our group is to determine whether and how astrocytes play an active and direct role in information processing. We want to unravel the molecular modalities and functional outcomes of neuroglial interactions in physiological and pathological conditions. More precisely, we want to understand how neurons and glia communicate in various regimes of activity and determine the outcome of disrupting their communication on neuronal functions, including their excitability, synaptic transmission, plasticity and synchronization.

Leader

Leader: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

Labex Memolife, ERC 2016
Publications

Publications: 

 

Dallérac, G., Rouach, N., 2016. Astrocytes as new targets to improve cognitive functions. Prog. Neurobiol.

Chever, O., Dossi, E., Pannasch, U., Derangeon, M., Rouach, N., 2016. Astroglial networks promote neuronal coordination. Sci Signal 9, ra6.

Pannasch, U., Freche, D., Dallérac, G., Ghézali, G., Escartin, C., Ezan, P., Cohen-Salmon, M., Benchenane, K., Abudara, V., Dufour, A., Lübke, J.H.R., Déglon, N., Knott, G., Holcman, D., Rouach, N., 2014. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat. Neurosci. 17, 549–558.

Chever, O., Lee, C.-Y., Rouach, N., 2014. Astroglial connexin43 hemichannels tune Basal excitatory synaptic transmission. J. Neurosci. 34, 11228–11232.

Pannasch, U., Rouach, N., 2013. Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci. Volume 36, Issue 7, July, 405–417.

Cortex and Epilepsy

Keywords: 

Epilepsie
neurone-synapse-circuit
in vitro

ENP label: 

2007

Research Unit Code: 

UMRS 1127 UMR 7225
  • Cortex, Hippocampus, Epilepsy, Slice.
  • Physiology, Anatomy, Pathology.       
  • Human epileptic tissue.  Dcx, KA.       
  • Presubiculum, EEG, Synapse, Circuit.
Institutions

Principal Institution: 

Université Pierre et Marie Curie

Affiliated institutions: 

Inserm
CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Publications

Publications: 

Huberfeld G, Menendez de la Prida L, Pallud J, Cohen I, Le Van Quyen M, Adam C, Clemenceau S,  Baulac M & Miles R. (2011)  Glutamatergic preictal discharges emerge at the transition to seizure in the  human epileptic temporal lobe.  Nature Neurosci. 14: 627-34.

Bazelot M, Dinocourt C, Cohen I & Miles R (2010)  Inhibitory field potentials in the CA3 region of rat hippocampus.    J Physiology 588: 2077-90.

Motti D, Le Duigou C, Eugene E, Chemaly N, Wittner L, Lazarevic D, Krmac H, Marstrand T, Valen E, Sanges R, Stupka E, Sandelin A, Cherubini E, Gustincich S & Miles R  (2010)  Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus.    European J Neuroscience 32: 1364-79.

Wittner L, Huberfeld G, Clémenceau S, Erőss L, Dezamis E, Entz L, Ulbert I, Baulac M, Freund TF, Maglóczky Zs &  Miles R. (2009)  The epileptic human hippocampal CA2 region generates spontaneous interictal like activity in vitro.  Brain 132: 3032-46.          

Eugene E, Delpiel C, Baulac S, Baulac M,  Fritschy JM, LeGuern E, Miles R & Poncer JC   (2007) Synaptic and non-synaptic effects of GABRG2 mutations linked to human epileptic syndromes.  J Neurosci 27: 14108-16.

Genetics and physiopathology of epilepsy

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

human genetics
Epilepsy molecular and cellular brain development
Transmission synaptique Epilepsie Cortex
physiopathology

ENP label: 

2009

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

O

Leader

Leader: 

Co leader: 

Personal

Team members: 

Elise Marsan
Christel Depienne
Virginie Lambrecq
Eric Noé
Théo Ribierre
GIuseppe Muraca
Manon Quiquand
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

Doctoral School: 

ED3C - n°158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM; ERC Consolidator Grant
Publications

Publications: 

Boillot M, Lee CY, Allene C, Leguern E, Baulac S*, Rouach N* (2016). LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Scientific Reports. Feb 16;6:21769. *co-last

Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. (2016) Depdc5 knockout rat: A novel model of mTORopathy. Neurobiol Dis 89:180-189.

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S. (2016) Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 57:994-1003. Article awarded the 2017 Clinical Epilepsia Prize.

Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E, Andermann F, Leguern E, Chassoux F, Picard F (2015). Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol. Apr;77(4):675-83. Article highlighted as Best Advances of 2015: Picks from the Neurology Today Editorial Advisory Board

Ishida S, Picard F, Rudolf G, Noé E, Achaz G, Thomas P, Genton P, Mundwiller E, Wolff M, Marescaux C, Miles R, Baulac M, Hirsch E, Leguern E and Baulac S (2013). Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nature Genetics, Apr 26;45(5):552-5. Highlighted in Nature Review Neurology