Epigenetics

Gene Regulation and Adaptive Behaviors

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

behavior
Epigenetics
Stress response
Molecular genetics
Glucocorticoid Receptor

ENP label: 

2014

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

U1130 UMR8246 UMCR18

To decipher the molecular mechanisms that allow brain gene expression to adapt to environmental challenges, we focus on the function of inducible transcription factors. Glucocorticoid hormones (GC) plays a key role in physiological and psychological responses to stress. It has multifaceted functions in the brain, most likely reflecting distinct actions in different brain areas and cell  populations.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie
Laboratory

Surname: 

Neuroscience Paris Seine
Publications

Publications: 

#Barik J, Marti F, Morel C, Fernandez SP, #Lanteri C, #Godeheu G, #Tassin JP, Mombereau C, Faure P, #Tronche F. Chronic stress triggers social aversion via GR in dopaminoceptive neurons. Science, 2013 339(6117):332-5

#Carrillo MA, #Pasco M, Arnoux I, #Maatouk L, Sanz Diez A, Delahaye M, Herrero MT, Newman TA, Calvo CF, Audinat E, #Tronche F, #Vyas S. Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death & Differentiation, 2013 20(11):1546-1557.

Revest JM, Le Roux A, Roullot-Lacarriere V, Kaouane N, Vallee M, Kasanetz F, Rouge-Pont F, #Tronche F, Desmedt A and Piazza PV. BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Molecular Psychiatry, 2013, doi: 10.1038, in press

Valtat B, Riveline JP, Zhang P, Singh A, Armanet M, Venteclef N, Besseiche A, Kelly D, #Tronche F, Ferré P, Gautier JF, Bréant B, Blondeau B. Fetal PGC-1? Overexpression Programs Adult Pancreatic ?-cell Dysfunction. Diabetes. 2013 62:1206-16

Romanò N, Yip SH, Hodson DJ, Guillou A, #Parnaudeau S, #Tronche F, Bonnefont X, Bunn SJ, Grattan DR, Mollard P, Martin AO. Electrical robustness during phenotypic plasticity of hypothalamic dopaminergic neurons. J Neuroscience, 33(10):4424-4433.