cognition

FRONTlab: the frontal systems, functions and dysfunctions

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

cognition
behavior
executive functions
neuroimaging
Prefrontal cortex

ENP label: 

2016

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.

Leader

Leader: 

Personal

Team members: 

Bruno DUBOIS Chef d'équipe
Antoni VALERO-CABRE
Benedicte BATRANCOURT
Emmanuelle VOLLE
Harald HAMPEL
Raffaella Lara MIGLIACCIO
Marc TEICHMAN
Michel THIEBAUT DE SCHOTTEN
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
UPMC
Publications

Publications: 

Azuar C, Reyes P, Slachevsky A, Volle E, Kinkingnehun S, Kouneiher F, Bravo E, Dubois B, Koechlin E, Levy R. Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions. Neuroimage. 2014 Jan 1;84:1053-60. doi: 10.1016/j.neuroimage.2013.09.031.

Aichelburg C, Urbanski M, Thiebaut de Schotten M, Humbert F, Levy R, Volle E. Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities. Cereb Cortex. 2014 Oct 19. pii: bhu254. 

Lagarde J, Valabrègue R, Corvol JC, Garcin B, Volle E, Le Ber I, Vidailhet M, Dubois B, Levy R. Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’. Brain. 2015 Feb;138(Pt 2):456-71. doi: 10.1093/brain/awu359. 

Gil Gonen-Yaacovi Leonardo Cruz de Souza Richard Levy Marika Urbanski Goulven Josse Emmanuelle Volle. Rostral and caudal prefrontal contribution to creativity: A meta-analysis of functional imaging data. Front. Hum. Neurosci. Published on 14 Aug 2013, doi:10.3389/fnhum.2013.00465. 

Thiebaut de Schotten M., Dell’Acqua F., Forkel S.J., Simmons A., Vergani F., Murphy D.G.M., Catani M. (2011) A lateralized brain network for visuospatial attentionNat Neurosci 14:1245-1246.(IF 14.191).

Interventional neuropsychology

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

cognitive functions
therapie génique
Maladie de Huntington
Maladie de Parkinson
greffe

ENP label: 

2012

Research Center / Institute: 

IMRB -Institut Mondor de Recherche Biomédicale

Research Unit Code: 

U955

Our team is built at the interface between basic research in cognition and clinical research in brain therapies.

We address two questions:

1) the bases of specifically human cognitive functions (language and social cognition), and the role of the striatum in such functions;

Leader

Leader: 

Personal

Team members: 

Gilles Fenelon
Charlotte Jacquemot
Laurent Cléret
Katia YOUSSOV
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris-Est Créteil
Laboratory

Surname: 

Laboratoire de Neuropsychologie Interventionnelle

Initiatives d'Excellence: 

Labex IEC: Institut d'Etude de la Cognition, Infrastructure nationale en biologie et santé: PROJET NeurATRIS
Publications

Publications: 

Teichmann M, Rosso C, Martini JB, Bloch I, Brugières P, Duffau H, Lehéricy S, Bachoud-Lévi AC. A cortical-subcortical syntax pathway linking Broca's area and the striatum. Hum Brain Mapp. 2015 Feb 16. doi: 10.1002/hbm.22769.

1. Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H,Lefaucheur JP, Thiriez C, #Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P,Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA,Hantraye P, Remy P, #Cesaro P, Mitrophanous KA. Long-term safety and tolerability of ProSavin, a lentiviral vector-based genetherapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet. 2014 Mar 29;383(9923):1138-46.

2. #Jacquemot, C., Dupoux, E & #Bachoud-Lévi, A-C. (2011). Is the word length effect linked to subvocal rehearsal ? Cortex, 47 pp.484-493

3. #Cleret de Langavant, L.,# Jacquemot, C., #Bachoud-Lévi, A-C. & Dupoux, E. (2013). The second person in «I» - «you» - «it»triadic interactions. Behavioral and Brain Sciences. 36(4):416-7

4. #Fénelon G, Soulas T, Zenasni F, #Cleret de Langavant L. The changing face of Parkinson's disease-associated psychosis: Across-sectional study based on the new NINDS-NIMH criteria. Mov Disord, 2010, 25: 763-6.

5. #Fénelon G, Soulas T, #Cleret de Langavant L, Trinkler, I, #Bachoud-Lévi A-C. Feeling of presence in Parkinson’s disease, JNeurol Neurosurg Psychiatry, 2011, 82: 1219-24.6. Trinkler I, #Cleret de Langavant L, #Bachoud-Lévi

Neuroimaging of Human Cognitive Architectures

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

language
Functional imaging
cognition
calculation
consciousness

ENP label: 

2007

Research Center / Institute: 

Neurospin

Research Unit Code: 

U992

Study of fine-grained cognitive representations and processes underlying cognition and perception; of contrast between conscious and non-conscious operations, to identify signatures of conscious level processing.

 Analyze the impact of education on the adult brain organization for reading and arithmetic.

 Study the development of language and consciousness in human infants and young children and human adult architecture for sentence-level processing of language.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Philippe Pinel
SCHURGER Aaron
MEYNIEL Florent
MARTI Sébastien
NELSON Matthew
HANNAGHAN Thomas
MOUTARD Clement
AMALRIC Marie
PINHEIRO CHAGAS Pedro
MAHEU Maxime
TROVO Bianca
POTIER WATKINS Cassandra
SANTORO Giovanna
LABRUNA Laurence
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Collège de France
CEA

University: 

Université Paris Sud 11

Doctoral School: 

ED419 - ED158
Laboratory

Surname: 

Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

Idex Neuro Saclay, ERC Advanced "NeuroSyntax"
Publications

Publications: 

 

Amalric, M., & Dehaene, S. (2016). Origins of the brain networks for advanced mathematics in expert mathematicians. Proceedings of the National Academy of Sciences, 201603205. https://doi.org/10.1073/pnas.1603205113

Meyniel, F., & Dehaene, S. (2017). Brain networks for confidence weighting and hierarchical inference during probabilistic learning. Proceedings of the National Academy of Sciences of the United States of America, 114(19), E3859–E3868. https://doi.org/10.1073/pnas.1615773114

Meyniel, F., Maheu, M., & Dehaene, S. (2016). Human Inferences about Sequences: A Minimal Transition Probability Model. PLoS Computational Biology, 12(12), e1005260. https://doi.org/10.1371/journal.pcbi.1005260

Nelson, M. J., El Karoui, I., Giber, K., Yang, X., Cohen, L., Koopman, H., … Dehaene, S. (2017). Neurophysiological dynamics of phrase-structure building during sentence processing. Proceedings of the National Academy of Sciences of the United States of America, 114(18), E3669–E3678. https://doi.org/10.1073/pnas.1701590114

Trübutschek, D., Marti, S., Ojeda, A., King, J.-R., Mi, Y., Tsodyks, M., & Dehaene, S. (2017). A theory of working memory without consciousness or sustained activity. eLife, 6. https://doi.org/10.7554/eLife.23871