Brain imaging

Neuro-modulation (UVSQ)

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

Brain imaging
consciousness
Neurological disability
Neuromodulation
Translational neuroscience

ENP label: 

2014

The long-term objective of this project is to apply high field MRI eventually combined with other neuroscience approaches, to develop physical (e.g. electric neurostimulation) and/or chemical (e.g. pharmacological delivery) devices of neuromodulation that target neuronal sites and manipulate specific aspects of cognition, motor behavior or consciousness, leading ultimately to the development of treatments for patients with related diseases (e.g. disorders of consciousness, Parkinson's disease...).

Institutions

Principal Institution: 

Inserm

University: 

Univ Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Unicog Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

IDEX Paris-Saclay / NeuroSaclay, IHU Handimedex
Publications

Publications: 

-Arsenault J, Nelissen K, Jarraya B#, Vanduffel W. Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex. Neuron. Mars 2013.

-D. Le Bihan, O. Joly#, T. Aso, L. Uhrig#, C. Poupon, N. Tani#, H. Iwamuro#, S-I. Urayama, B. Jarraya# Brain tissue water comes in two pools: Evidence from diffusion and R2? measurements with USPIOs in non human primates. NeuroImage. 2012 May 11.

-K Nelissen*, B Jarraya* #, J Arsenault, B R. Rosen, L L. Wald, J B. Mandeville, J. J. Marota, W Vanduffel. Neural correlates of formation and retention of cocaine-induced stimulus-reward associations. Biological Psychiatry. 2012 Mar 20. * co-authoring

-L Ciobanu, O Reynaud, L Uhrig#, B Jarraya#, D Le Bihan. Effects of Anesthetic Agents on Brain Blood Oxygenation Level Revealed with Ultra-High Field MRI PlosONE. 2012;7(3):e32645.

- N Tani#, O Joly#, H Iwamuro#, L Uhrig#, C J. Wiggins, C Poupon, H Kolster, W Vanduffei, D Le Bihan, S Palfi#, B Jarraya# Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI. NeuroImage 2011 Sep 1;58(1):60-8.

- Jarraya B#, Boulet S, Scott Ralph G, Jan C, Bonvento G, Azzouz M, E. Miskin J, Shin M, DelzescauxT, Drouot X, Hérard A.S, M. Day D, Brouillet E, M. Kingsman S, Hantraye P, A. Mitrophanous K, D. Mazarakis N, Palfi S#. Dopamine Gene Therapy for Parkinson?s Disease in a Nonhuman Primate Without Associated Dyskinesia. Science Translational Medicine Vol 1 2009.

Laboratory for the Psychology of Child Development and Education

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

Learning
Brain imaging
neurocognitive developpment
executive functions
inhibitory control
education

ENP label: 

2014

Research Center / Institute: 

Institut de Psychologie Paris Descartes

Research Unit Code: 

U8240

The LaPsyDÉ is one of the few lab in France conducting basic researches from childhood to adulthood that combine (1) integrated behavioral approaches of cognitive development in different domains (object perception, numerical cognition, categorization, reasoning, decision making and creativity) and (2) multimodal brain imaging (anatomical and functional MRI, high density EEG) of brain development, especially in normal preschoolers and school-age children. Our fundamental researches have also direct applications, in particular in education.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Descartes
Sorbonne Paris Cité
Université de Caen

University: 

Université Paris Descartes

Doctoral School: 

ED261
Laboratory

Initiatives d'Excellence: 

IDEX Sorbonne Paris Cité
Publications

Publications: 

Krakowski CS, Poirel N, Vidal J, Roëll M, Pineau A, Borst G, Houdé O. The forest, the trees, and the leaves: Differences of processing across development. Dev Psychol. 2016 Aug;52(8):1262-72. doi: 10.1037/dev0000138.

Cachia A, Borst G, Vidal J, Fischer C, Pineau A, Mangin JF, Houdé O. The shape of the ACC contributes to cognitive control efficiency in preschoolers. J Cogn Neurosci. 2014 Jan;26(1):96-106. doi: 10.1162/jocn_a_00459. Epub 2013 Aug 5.

Borst G., Pineau A., Poirel N., Cassotti M., & Houdé O. (2013). Inhibitory control efficiency in a Piaget-like class-inclusion task in school-age children and adults: A developmental negative priming study. Developmental Psychology 49, 1366-1374.

De Neys W., Rossi S., & Houdé O. (2013). Bats balls and substitution sensitivity: Cognitive misers are no happy fools. Psychonomic Bulletin & Review 20, 269-273.

Rossi S., Lubin A., Simon G., Lanoë C., Poirel N., Cachia A., Pineau A., & Houdé O. (2013). Structural brain correlates of
executive engagement in working memory: Children's inter individual differences are reflected in the anterior insular cortex. Neuropsychologia 51, 1145-1150.

Cassotti M., Habib M., Poirel N., Aïte A., Houdé O., & Moutier S. (2012). Positive emotional context eliminates the framing effect in decision-making. Emotion 12, 926-931.

Poirel N., Borst G., Simon G., Rossi S., Cassotti M., Pineau A., & Houdé O. (2012). Number conservation is related to children's prefrontal inhibitory control: An fMRI study of a Piagetian task. PLoS ONE 7(7): e40802.

Genes and Dynamics of Memory Systems

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

olfactory learning
long-term memory
Drosophila mutants
neuronal networks
Alzheimer's disease
Brain imaging
energy metabolism

ENP label: 

2012

Research Center / Institute: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Research Unit Code: 

UMR8249

 

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Valérie Goguel
Pierre-Yves Plaçais
Alice Pavlowsky
Laure Pasquer
Lisa Scheunemann
Eloïse de Tredern
Julia Minatchy
Johann Schor
Olivier Mantha
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

ESPCI
Laboratory

Surname: 

Laboratoire Plasticité du Cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL, EMBO
Publications

Publications: 

Dolan, M.-J., Belliart-Guérin, G., Bates, A.S., Frechter, S. , Lampin-Saint-Amaux, A. , Aso, Y. , Roberts, R.J.V. , Schlegel, P., Wong, A., , Hammad, A. , Bock, D., Rubin, G.M., Preat, T., Plaçais, P.-Y.* and Jefferis, G.S.X.E.* (2018). Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila. Neuron, 100: 1-18.

Pavlowsky, A., Schor , J., Plaçais, P.-Y., and Preat, T. (2018). A GABAergic feedback shapes dopaminergic input  on the Drosophila mushroom body  to promote appetitive long-term memory. Curr Biol, 28: 1–11.

Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M., and Preat, T. (2018). Dunce phosphodiesterase acts as a checkpoint for Drosophila long-term memory in a pair of serotonergic neurons. Neuron, 98:350-365.

Turrel, O., Goguel, V.* and Preat, T.* (2017). Drosophila neprilysin 1 rescues memory deficits caused by amyloid-β peptide. J Neurosci, 37(43):10334-10345.

Plaçais, P.-Y., de Tredern, E., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., and Preat, T. (2017). Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. Nat Commun, 8:15510.

Musso, P.-Y., Tchenio, P.* and Preat, T.* (2015). Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila. Cell Rep, 10: 1-9.

Plaçais, P.-Y. and Preat, T. (2013). To favor survival under food shortage, the brain disables costly memory. Science, 339(6118): 440-442.

Plaçais, P.-Y., Trannoy, S., Isabel, G., Aso, Y., Siwanowicz, I., Belliart-Guérin, G., Vernier, P., Birman, S., Tanimoto, H. and Preat, T. (2012). Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nat Neurosci, 15(4): 592-599.

Séjourné, J., Plaçais, P.-Y., Aso, Y., Siwanowicz, I., Trannoy, S., Vladimiros, T., Tedjakumala, S.R., Rubin, G.M., Tchénio, P., Ito, K., Isabel, G., Tanimoto, H.* and Preat, T.* (2011). Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci, 14(7): 903-910.



Imaging and Psychiatry

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Depression
schizophrenia
autism
Brain imaging
addiction

ENP label: 

2012

Research Center / Institute: 

Imagen Orsay Service Hospitalier Frédéric Joliot

Research Unit Code: 

U1000

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CEA

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

ED158
Laboratory

Surname: 

Laboratoire Imagerie et Psychiatrie

Initiatives d'Excellence: 

IHU Necker
Publications

Publications: 

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192