Transmission at glutamate synapses in the cerebellar cortex: biophysical, pharmacological and photochemical approaches.
Our research projects have two tightly linked goals: (i) to decipher the cellular and molecular mechanisms that underlie the development of the auditory system, the way it processes acoustic signals (mechanotransduction (MET), and the synaptic properties of the auditory sensory cells and their afferents; and (ii) to identify the genes and pathogenic pathways causing deafness in humans in early- and late-onset forms, as well as forms accompanied by retinal defects (Usher syndrome). We also search for therapeutic tools based on these findings.
Membrane trafficking allows for the communication between the different membrane compartments of the biosynthetic and endocytic pathways and for the communication between cells and their environment through the secretion of signalling molecules by exocytosis and capture of nutrients by endocytosis. Exocytosis and endocytosis are crucial to maintain cell homeostasis and are also involved in differentiation and morphogenesis of cells.