behavior

FRONTlab: the frontal systems, functions and dysfunctions

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

cognition
behavior
executive functions
neuroimaging
Prefrontal cortex

ENP label: 

2016

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.

Leader

Leader: 

Personal

Team members: 

Bruno DUBOIS Chef d'équipe
Antoni VALERO-CABRE
Benedicte BATRANCOURT
Emmanuelle VOLLE
Harald HAMPEL
Raffaella Lara MIGLIACCIO
Marc TEICHMAN
Michel THIEBAUT DE SCHOTTEN
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
UPMC
Publications

Publications: 

Azuar C, Reyes P, Slachevsky A, Volle E, Kinkingnehun S, Kouneiher F, Bravo E, Dubois B, Koechlin E, Levy R. Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions. Neuroimage. 2014 Jan 1;84:1053-60. doi: 10.1016/j.neuroimage.2013.09.031.

Aichelburg C, Urbanski M, Thiebaut de Schotten M, Humbert F, Levy R, Volle E. Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities. Cereb Cortex. 2014 Oct 19. pii: bhu254. 

Lagarde J, Valabrègue R, Corvol JC, Garcin B, Volle E, Le Ber I, Vidailhet M, Dubois B, Levy R. Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’. Brain. 2015 Feb;138(Pt 2):456-71. doi: 10.1093/brain/awu359. 

Gil Gonen-Yaacovi Leonardo Cruz de Souza Richard Levy Marika Urbanski Goulven Josse Emmanuelle Volle. Rostral and caudal prefrontal contribution to creativity: A meta-analysis of functional imaging data. Front. Hum. Neurosci. Published on 14 Aug 2013, doi:10.3389/fnhum.2013.00465. 

Thiebaut de Schotten M., Dell’Acqua F., Forkel S.J., Simmons A., Vergani F., Murphy D.G.M., Catani M. (2011) A lateralized brain network for visuospatial attentionNat Neurosci 14:1245-1246.(IF 14.191).

Gene Regulation and Adaptive Behaviors

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

behavior
Epigenetics
Stress response
Molecular genetics
Glucocorticoid Receptor

ENP label: 

2014

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

U1130 UMR8246 UMCR18

To decipher the molecular mechanisms that allow brain gene expression to adapt to environmental challenges, we focus on the function of inducible transcription factors. Glucocorticoid hormones (GC) plays a key role in physiological and psychological responses to stress. It has multifaceted functions in the brain, most likely reflecting distinct actions in different brain areas and cell  populations.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie
Laboratory

Surname: 

Neuroscience Paris Seine
Publications

Publications: 

#Barik J, Marti F, Morel C, Fernandez SP, #Lanteri C, #Godeheu G, #Tassin JP, Mombereau C, Faure P, #Tronche F. Chronic stress triggers social aversion via GR in dopaminoceptive neurons. Science, 2013 339(6117):332-5

#Carrillo MA, #Pasco M, Arnoux I, #Maatouk L, Sanz Diez A, Delahaye M, Herrero MT, Newman TA, Calvo CF, Audinat E, #Tronche F, #Vyas S. Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death & Differentiation, 2013 20(11):1546-1557.

Revest JM, Le Roux A, Roullot-Lacarriere V, Kaouane N, Vallee M, Kasanetz F, Rouge-Pont F, #Tronche F, Desmedt A and Piazza PV. BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Molecular Psychiatry, 2013, doi: 10.1038, in press

Valtat B, Riveline JP, Zhang P, Singh A, Armanet M, Venteclef N, Besseiche A, Kelly D, #Tronche F, Ferré P, Gautier JF, Bréant B, Blondeau B. Fetal PGC-1? Overexpression Programs Adult Pancreatic ?-cell Dysfunction. Diabetes. 2013 62:1206-16

Romanò N, Yip SH, Hodson DJ, Guillou A, #Parnaudeau S, #Tronche F, Bonnefont X, Bunn SJ, Grattan DR, Mollard P, Martin AO. Electrical robustness during phenotypic plasticity of hypothalamic dopaminergic neurons. J Neuroscience, 33(10):4424-4433.

Neuronal Circuit Development Group

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

zebrafish
Optogenetics
behavior
Vision
neural circuits

ENP label: 

2012

Research Center / Institute: 

Institut Curie - Centre de Recherche - Paris/Orsay

Research Unit Code: 

U934 - UMR3215

The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We are examining the formation and function of the visual system in zebrafish larvae using in vivo time-lapse microscopy and state-of-the-art “connectomic” and “optogenetic” approaches to monitor and perturb neuronal activity. We apply complementary cellular and molecular analyses to dissect this circuit and identify the neuronal substrate of visual behaviors.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Karine Duroure
Thomas Auer
Christoph Gebhardt
Vincenzo Di Donato
Flavia De Santis
Celine Revenu
Shahad Albadri
Noe Testa
Institutions

Principal Institution: 

Institut Curie

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Edith Heard

Initiatives d'Excellence: 

Labex DEEP
Publications

Publications: 

Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., and Del Bene, F. Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. Neuron (2016)

Di Donato, V., De Santis, F., Auer, T. O., Testa, N., Sanchez-Iranzo, H., Mercader, N., Concordet, J. P., and Del Bene, F.  2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research (2016)

Auer, T. O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J. P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H., and Del Bene, F. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLife (2015)

Auer, T. O., Duroure, K., Concordet, J. P., and Del Bene, F. CRISPR/Cas9-mediated conversion of eGFP- into Gal4-transgenic lines in zebrafish. Nature protocols (2014)

Auer, T. O., Duroure, K., De Cian, A., Concordet, J. P., and Del Bene, F.  Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome research (2014)

 

Zebrafish Neurogenetics (ZEN)

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

zebrafish
behavior
motivation
neurogenesis
stem cell
telencephalon
quiescence

ENP label: 

2009

Research Center / Institute: 

Institut Pasteur

Research Unit Code: 

UMR3738

The central nervous system (CNS) of vertebrates is a complex arrangement of neurons and glial cells that underlie brain physiology and animal behavior. These cells are set-up in defined numbers at specific locations from neural progenitors or Neural Stem Cells (NSCs), largely during early stages of life. In addition, the maintenance of NSCs in the brain until adulthood is a general phenomenon, likely crucial to late adaptation events. Indeed, defects in adult neurogenesis have been correlated with neurodegenerative and mood-related disorders, and also occur during ageing.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Alessandro Alunni
Marion Coolen
Institutions

Principal Institution: 

CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 515 Complexité du Vivant
Laboratory

Surname: 

Department of Developmental and stem cell Biology

Initiatives d'Excellence: 

Labex Revive
Publications

Publications: 

L. Dirian, S. Galant, M. Coolen, J. Livet, W. Chen, S. Bedu, C. Houart, L. Bally-Cuif* and I. Foucher*. Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells. Dev. Cell 30:123-136 (2014).

G. FurlanV. Cuccioli, N. Vuillemin, L. Dirian, A. Janue Muntasell, M. CoolenN. DrayS. Bedu, C. Houart, E. Beaurepaire, I. Foucher*and L. Bally-Cuif*. Life-long neurogenic activity of individual neural stem cells and continuous growth establish an outside-in architecture in the teleost pallium. Curr. Biol., in press (2017). * co-senior authorship. 

S. KatzD. Cussigh, N. Urban, F. Guillemot, L. Bally-Cuif* and M. Coolen*. A non-canonical nuclear role for microRNA-9 and Argonaute proteins in balancing the quiescent and activated adult neural stem cell state. Cell Reports 17: 1383-1398 (2016).    

S. GalantG. FurlanM. CoolenL. DirianI. Foucher and L. Bally-CuifEmbryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain. Dev Biol. pii: S0012-1606(16)30424-9 (2016).

N. DrayS. Bedu, N. Vuillemin, A. AlunniM. CoolenM. Krecsmarik, W. Supatto, E. Beaurepaire and L. Bally-Cuif. Large-scale live imaging of adult neuro stem cells in their endogenous niche. Development 142: 3592-3600 (2015).

Neural Circuits and Behaviour

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

behavior
Olfactory processing
mouse genetics
imaging

ENP label: 

2011

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR7241 U1050

My laboratory is interested in the functional properties of neural circuits underlying odor perception. We use a combination of molecular genetic, in vivo imaging and behavioral approaches in mice to understand the logic of odor coding in higher olfactory centers in the cortex.

Leader

Leader: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

Labex MemoLife
Publications

Publications: 

Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi GB,Fleischmann A. Molecular signatures of neural connectivity in the olfactory cortex. Nat Commun. 2016 Jul 18;7:12238. doi: 10.1038/ncomms12238.

Fleischmann A, Abdus-Saboor I, Sayed A, Shykind B (2013) Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. PLoS Biol 11(5): e1001568. doi:10.1371/journal.pbio.1001568 

K. Angelo, D. Pimentel, B. Pichler, A. Fleischmann, E. Rancz & T. Margrie , A biophysical signature of network affiliation and sensory processing in mitral cells. Nature, Aug16;488(7411):375-8.(2012)

Glinka M.E., Samuels B.A., Teillon J., Mei D.F., Shykind B.M., Hen R. & Fleischmann A., Olfactory deficits cause anxiety-like behaviors in mice. J. Neurosci., 32(19):6718-6725 (2012)

Choi G.B., Stettler D.D., Kallman B.R., Bhaskar S.T., Fleischmann A. & Axel R. (2011), Driving opposing behaviors with ensembles of piriform neurons. Cell146:1004-1015

Fleischmann A., Shykind B.M., Sosulski D.L., Franks K.M, Glinka M.E., Mei D.F., Yonghua S., Kirkland J., Mendelsohn M., Albers M.W. & Axel R., Mice with a "monoclonal" nose: perturbations in an olfactory map impair odor discrimination.Neuron. Dec 26; (60):1-14.  (2008)

Fleischmann A., Jochum W., Eferl R., Witowsky J. & Wagner E.F., Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell.Dec;4(6):477-82. (2003) 

 

Spinal Sensory Signalling

Main field of research: 

Computational neurosciences / neural theory

Keywords: 

behavior
Optogenetics
Locomotion
Circuit-breaking
Spinal cord

ENP label: 

2010

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Sensory systems transduce fluctuations in the physical world into patterns of action potentials which are integrated to control motor outputs. Locomotion relies on genetically determined circuits constituted by spinal interneurons and capable of generating oscillations. Local sensory information about the outside world or the internal state seem to alter thesemotor patterns by triggering, stopping or steering locomotion.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, ERC Grant 2013-18
Publications

Publications: 

Knafo S#, Wyart C@ [2017]. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. eLife, in press.

Knafo S#,%, Fidelin K#,%, Prendergast A+, Tseng PE, Parrin A, Dickey CW, Bohm UL#, Nunes Figueiredo S, Thouvenin O, Pascal-Moussellard H, Wyart C@ [2017]. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. eLife 6:e25260 DOI: 10.7554/eLife.25260

Djenoune L#, Desban L#, Gomez J, Sternberg JR#, Prendergast A+, Langui D, Quan FB#, Marnas H#, Auer TO, Rio JP, Del Bene F, Bardet PL@, Wyart C@ [2017]. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes, Scientific Reports 7:719.

Hubbard J+, Böhm U#, Prendergast A+, Tseng PE, Stokes C+, Newman M, Wyart C@ [2016]. GABAergic sensory neurons project onto key elements of the escape circuit, Current Biology 26: 2841-2853.

Sternberg J#,%, Severi K+,%, Fidelin K, Gomez J, Ihara H, Alcheikh Y, Hubbard J, Kawakami K, Suster M, Wyart C@[2016]. Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion. Current Biology, 26: 2319-28.