September 2010
09 October 2015

Years 2-4

October 1, 2011 - September 30, 2014
ED 157
Université Paris Descartes

Rôle de IL-1 Receptor Accessory Protein like 1 (IL1RAPL1) dans la fonction synaptique


PostDoc at Institut Necker Enfants Malades in Franck OURY’s lab.

Year 1

GIRAULT Jean Antoine


ENP student Mariana Ramos-Brossier investigates IL-1 receptor accessory protein like 1 (IL1RAPL1) and its role in synaptic functions. She contributed to a recent publication on this protein and its link to associative memory in intellectual disorders. She and her colleagues found that mice lacking IL1RAPL1 had imbalanced inhibitory to excitatory neural subcircuits in the amygdala linked to behavioral deficits. They also observed altered function from thalamic projections onto principal cells but not onto interneurons. For more details on this finding, check out the article:

 Houbaert X, Zhang CL, Gambino F, Lepleux M, Deshors M, Normand E, Levet F, Ramos M, Billuart P, Chelly J, Herzog E, Humeau Y. Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder. J Neurosci. 21 August 2013. 33(34): 13805-19.


Key words: IL-1 receptor accessory protein like 1 Associative memory Intellectual disorders Excitatory synapses

Figure 1B2 from Houabert et al., J Neuro, 2013. Deficits in recall to learned conditioned stimuli seen in ilrapl1 knockout mice relative to wild-type.


Starting from human genetics, our team isolates some genes involved in intellectual disability and others disorders of the mentalspectrum. Together with biologists and clinicians from AP-HP, we...