March 2009
04 June 2014

Years 2-4

October 1, 2010 - September 30, 2013
ED 158
Université Pierre et Marie Curie

Spatiotemporal dynamics in neocortex:Quanti cation, analysis, models


Post doc position at the Salk Institute for Biological Studies in La Jolla, CA, at the lab of Terry Sejnowski 

Year 1

Université Paris Descartes


Lyle Muller, Alexandre Reynaud, Frédéric Chavane & Alain Destexhe's researches on "The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave" has been published in Nature on April 28th 2014. Publication is available here

Lyle Muller gave an oral presentation at CNS 2013 PARIS  22nd Annual Computational Neuroscience Meeting.

Lyle Muller is pushing forward our understanding of phase-locking of spikes in heterogeneous neural populations. Together with his ENP colleagues Boris Gutkin and Romain Brette, he studied how local field potential-to-spike timing is learned and coupled in feed-forward networks. They found that stable, phase-locked points existed for neurons with plastic (changeable or shapeable) synapses. These points depend on the frequency of the input oscillations, the time constants of spike-timing dependent plasticity (STDP), and the relationship between potentiation and de-potentiation of the STDP rule. For more information, check out the article :

Muller L, Brette R, Gutkin B. Spike-timing dependent plasticity and feed-forward input oscillations produce precise and invariant spike-phase locking. Front Comput Neurosci. 15 November 2011. 5:45.


Figure 4 from Muller et al., Front Comp Neurosci., 2011. Simulations of spike-timing depending plasticity.


Integrative properties of neocortical neurons in high-conductance states.In awake animals, neurons of cerebral cortex are in a "high-conductance" (HC) state, characterized by a sustained, irregular...