Keerthana IYER
March 2010
16 September 2015
08-11-2015

Years 2-4

October 1, 2011 - September 30, 2014
ED 158
Université Pierre et Marie Curie

The role of complement system-related genes in synapse formation and specificity in the olivo-cerebellar network

SELIMI Fekrije

Year 1

GIRAULT Jean Antoine
CHEDOTAL Alain

Biography/CV

During her PhD, Keerthana investigated the molecular basis of the formation and specificity of two synapses formed on the same target neuron using the olivo-cerebellar network as a model system. With a particular focus on proteins related to the complement system, she contributed to a study demonstrating that different members of the C1Q family are important determinants of the identity and specific connectivity of the two excitatory synapses formed on cerebellar Purkinje cells. 



Publication list:

Sigoillot SM, Iyer K, Binda F, Calvo IG, Talleur M,  Vodjdani G, Isope P, Selimi F. The C1QL1 secreted protein and its receptor, the adhesion-GPCR BAI3, control the synaptic connectivity of convergent excitatory inputs on cerebellar Purkinje cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] Pubmed PMID: 25660030

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. Pubmed PMID: 23628982  

Team

Fekrije SELIMI
Le cerveau est composé de nombreux types de neurones communiquant entre eux via descontacts spécifiques, les synapses. Chaque neurone peut être contacté par plusieurs typesde neurones et à son tour...
Glutamate is the major neurotransmitter of CNS. Before its exocytotic release in the synaptic cleft, glutamate is loaded into synaptic vesicles by three transporters named VGLUT1-3. In the rodent...