Keerthana IYER
March 2010
16 September 2015
08-11-2015

Years 2-4

October 1, 2011 - September 30, 2014
ED 158
Université Pierre et Marie Curie

The role of complement system-related genes in synapse formation and specificity in the olivo-cerebellar network

SELIMI Fekrije

Year 1

GIRAULT Jean Antoine
CHEDOTAL Alain

Biography/CV

During her PhD, Keerthana investigated the molecular basis of the formation and specificity of two synapses formed on the same target neuron using the olivo-cerebellar network as a model system. With a particular focus on proteins related to the complement system, she contributed to a study demonstrating that different members of the C1Q family are important determinants of the identity and specific connectivity of the two excitatory synapses formed on cerebellar Purkinje cells. 



Publication list:

Sigoillot SM, Iyer K, Binda F, Calvo IG, Talleur M,  Vodjdani G, Isope P, Selimi F. The C1QL1 secreted protein and its receptor, the adhesion-GPCR BAI3, control the synaptic connectivity of convergent excitatory inputs on cerebellar Purkinje cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] Pubmed PMID: 25660030

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. Pubmed PMID: 23628982  

Team

Glutamate is the major neurotransmitter of CNS. Before its exocytotic release in the synaptic cleft, glutamate is loaded into synaptic vesicles by three transporters named VGLUT1-3. In the rodent...