Heike BLOCKUS
September 2011
24 September 2015
20-11-2015

Years 2-4

October 1, 2012 - September 30, 2015
ED 158
Université Pierre et Marie Curie

Cellular and Molecular mechanism of Robo receptors in brain commissures

CHEDOTAL Alain

Feb 2016 - : PostDoc at Columbia University, NY - Department of Neuroscience, in Franck Polleux's lab

Year 1

September 1, 2011 - September 1, 2012
UEI (Unité d'Enseignement isolé)
UPMC
JAY Thérèse
CHEDOTAL Alain

Biography/CV

1: Dantas-Barbosa C, Bergthold G, Daudigeos-Dubus E, Blockus H, Boylan JF,Ferreira C, Puget S, Abely M, Vassal G, Grill J, Geoerger B. Inhibition of theNOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumoractivity in established glial tumors. Anticancer Drugs. 2014 Dec 6. [Epub aheadof print] PubMed PMID: 25486598.

2: Zelina P*, Blockus H*, Zagar Y*, Péres A, Friocourt F, Wu Z, Rama N, Fouquet C,Hohenester E, Tessier-Lavigne M, Schweitzer J, Roest Crollius H, Chédotal A.Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution.Neuron. 2014 Dec 17;84(6):1258-72. doi: 10.1016/j.neuron.2014.11.004. Epub 2014Nov 26. PubMed PMID: 25433640.

* These authors contributed equally

3: Kadaré G, Gervasi N, Brami-Cherrier K, Blockus H, El Messari S, Arold ST,Girault JA. Conformational dynamics of the focal adhesion targeting domaincontrol specific functions of focal adhesion kinase in cells. J Biol Chem. 2015Jan 2;290(1):478-91. doi: 10.1074/jbc.M114.593632. Epub 2014 Nov 12. PubMed PMID:25391654; PubMed Central PMCID: PMC4281750.

4: Blockus H, Chédotal A. The multifaceted roles of Slits and Robos in corticalcircuits: from proliferation to axon guidance and neurological diseases. CurrOpin Neurobiol. 2014 Aug;27:82-8. doi: 10.1016/j.conb.2014.03.003. Epub 2014 Mar 31. PubMed PMID: 24698714.

5: Blockus H, Chédotal A. Dystroglycan adds more sugars to the midline cocktail. Neuron. 2012 Dec 6;76(5):864-7. doi: 10.1016/j.neuron.2012.11.017. PubMed PMID:23217735.

6: Geoerger B, Blockus H. Everolimus for astrocytomas in tuberous sclerosiscomplex. Lancet. 2013 Jan 12;381(9861):95-6. doi: 10.1016/S0140-6736(12)61221-5. Epub 2012 Nov 14. PubMed PMID: 23158521.

7: Bill A, Blockus H, Stumpfe D, Bajorath J, Schmitz A, Famulok M. A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time. J Am Chem Soc. 2011 Jun 1;133(21):8372-9. doi:10.1021/ja202513s. Epub 2011 May 4. PubMed PMID: 21517092.

8: Stumpfe D, Bill A, Novak N, Loch G, Blockus H, Geppert H, Becker T, Schmitz A,Hoch M, Kolanus W, Famulok M, Bajorath J. Targeting multifunctional proteins byvirtual screening: structurally diverse cytohesin inhibitors with differentiated biological functions. ACS Chem Biol. 2010 Sep 17;5(9):839-49. doi:10.1021/cb100171c. PubMed PMID: 20614894.


Team

Alain CHEDOTAL
Nervous systems are composed of a network of synaptic connections among excitable cells. This network develops as axons extend from presynaptic neurons and grow often long distances to reach their...