Synaptic plasticity and neuronal circuits

Co-Leaders

Research center

Institution

Inserm
Sainte Anne
Université Paris Descartes

Laboratory

U894

Keywords

Hippocampe, mémoire, interneurones, pasticité synaptique, émotions
Available to host a PhD student

Publications

Piskorowski RA, Nasrallah K, Diamantopoulou A, Mukai J, Hassan SI, Siegelbaum SA, Gogos JA, Chevaleyre V.Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome.Neuron. 2016 Jan 6;89(1):163-76. doi: 10.1016/j.neuron.2015.11.036.

Chevaleyre V.& Piskorowski RA. (2014)  Modulating excitation through plasticity at inhibitory synapses. Frontiers in Neurosciences. 8, doi:10.3389 

Piskorowski R.A. and Chevaleyre V.  (2013) Delta opioid receptor mediate unique plasticity onto parvalbumin-expressing interneurons in area CA2 of the hippocampus  J. Neuroscience. 33(36): 14567-78.   

Piskorowski R.A. and Chevaleyre V. (2012) Synaptic integration by different dendritic compartments of hippocampal CA1 and CA2 pyramidal neurons. Cellular and Molecular Life Science 69(1); 75-88.

Pavlopoulos E; Trifilieff P; Chevaleyre V; Zairis S; Fioriti L; Malleret G; Kandel E.R. (2011) Non-Proteolytic Ubiquitination by Neuralized1 Leads to Activation of CPEB3: A Novel Function of the Ubiquitin System in Synaptic Plasticity and Memory Storage. Cell 147(6); 1369-83.

Piskorowski R, Santoro B, Siegelbaum SA. (2011) TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons. Neuron. 70(3):495-509

Chevaleyre V. and Siegelbaum S.A. (2010) Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop. Neuron 66(4):560-72

Chevaleyre V., Heifets B.D., Kaeser P., Südhof T.C., Castillo P.E. (2007) Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signalling and RIM1. Neuron.  54 (5): 801-12.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our team is interested in understanding the processes underlying the formation of new memories.  The hippocampus is a brain region that has long been considered to be central in memory storage and retrieval. Networks of inhibitory neurons in the hippocampus are critical for hippocampal activity, and play a central role in learning.

Our research is focused on area CA2, a region that not only contains a very high density of interneurons, but also received direct synaptic input from intra- and extra- hippocampal structures such as the cortex and hypothalamus. Long overlooked, area CA2 is emerging as a distinct region of the hippocampus with unique properties. Furthermore, CA2 is the only region in the hippocampus that is altered after the onset of schizophrenia and dementia. We hypothesize that CA2 is acting as a gate to inhibit or enhance information transfer within the hippocampal network. Using electrophysiology and optogenetic techniques, we are investigating the activity dependent plasticity and role of intra-hippocampal and extra-hippocampal connections that target CA2 during both physiological and pathological conditions.