SCaNR : Stem Cells and Neurogenesis in the Retina

Leader

Research center

Bâtiment 145, Centre d'études de Saclay
91191 Gif sur Yvette
Philippe Vernier

Institution

CNRS
ED 568 BioSigNe
Université Paris Sud 11

Laboratory

Centre d’Études et de Recherches Thérapeutiques en Ophtalmologie (CERTO)
UMR9197
Idex NeuroSaclay

Keywords

Neural stem cells
Retina
Proliferation
regeneration
Signaling pathways
Available to host a PhD student

Publications

Hamon, A., Roger, J. E., Yang, X.-J. and Perron, M. (2016). Müller glial cell-dependent regeneration of the neural retina: An overview across vertebrate model systems. Dev. Dyn. doi: 10.1002/dvdy.24375. 

Cabochette P, Vega-Lopez G, Bitard J, Parain K, Chemouny R, Masson C, Borday C, Hedderich M, Henningfeld K, LockerM, Bronchain O, Perron M. (2015). YAP controls retinal stem cell DNA replication timing and genomic stability. eLife 4:e08488.

Mazurier N, Parain K, Parlier D, Pretto S, Vernier P, Locker M, Bellefroid E and Perron M.  (2014). Ascl1 as a novel player inthe Ptf1a transcriptional network for GABAergic cell specification in the retina. Plos One 9(3):e92113.

El Yakoubi W, Borday C, Hamdache J, Parain K, Tran HT, Vleminckx K, Perron M and Locker M (2012). Hes4 controlsproliferative properties of neural stem cells during retinal ontogenesis. Stem Cells 30:2784-95.

Borday C, Cabochette P, Parain K, Mazurier N, Janssens S, Tran HT, Sekkali B, Bronchain O, Vleminckx K, Locker M & Perron M. (2012). Antagonistic cross-regulation between Wnt and Hedgehog signaling pathways controls post-embryonic retinalproliferation. Development 139:3499-509.

Parain K, Mazurier N, Bronchain O, Borday C, Cabochette P, Chesneau A, Colozza G, el Yakoubi W, Hamdache J,Gilchrist M, Pollet N, Perron M. (2012). A large scale screen for neural stem cell markers in Xenopus retina. Developmental Neurobiology 72(4): 491–506.

Fields of research

Neurogenetics / neurodevelopment

Research Theme

Our research program focuses on neural stem cells in both mice and Xenopus retina. The amphibian retina contains a population ofneural stem cells, which, in contrast to the mammalian situation, are active, allowing continuous tissue growth throughout the animallife, as well as regeneration following retinal damage.

Using this first model, our team is investigating how signalling pathways andintrinsic factors work in concert to finely regulate the balance between quiescence, proliferation and differentiation in physiological andneurodegenerative conditions. In addition, the laboratory of Retina France association (the CERTO) has joined our research group since December 2012. Together, we are now also developing researches in murine models of neurodegenerative diseases.

Our goal is to uncover molecular cues that could awake the neurogenic potential of dormant mammalian retinal stem cells and therebystimulate regeneration, an approach that should contribute to the elaboration of stem-cell-based therapeutic strategies to treat retinaldystrophies.

 



Team members

Laurent Théodore
Odile Bronchain
Morgane Locker
Christel Masson-Garcia
Jérôme Roger
Karine Parain
Albert Chesneau
Juliette Bitard
Elodie Grellier
Rahul Langhe
Divya Ail
Elena Braginskaja
Annaïg Hamon
Suma Medisetti
Anaïs Laine