Decomposing the retinal circuit by population recording and single cell stimulation
Dates:January 2, 2018 - June 29, 2018
Application deadline:June 29, 2018
~ Jan-March 2018
~ April-June 2018
The retina is an ideal system to understand how neuronal networks are able to process neuronal information. The signal flows from photoreceptors through a few layers of neurons to the retinal ganglion cells, which send spikes down the optic nerve to the brain. We have combined several state of the art tools to measure, and stimulate, several intermediate cells of the retinal network, while recording a large fraction of the output layer. For this we have combined several techniques: multi-electrode array (MEA) recordings allowing simultaneous recording of large ensembles of output cells; Two-photon stimulation and imaging at very high spatial resolution, optogenetic tools allowing cell-specific activation. We combine these techniques to precisely stimulate the retinal network and simultaneously measure the impact of these stimulations on the retinal output, and use modeling to understand how the retinal network proces information.
Institut de la Vision - Physiology department - 17, rue Moreau 75012 Paris - +33 1 53 46 25 32 - Olivier.firstname.lastname@example.org