Perception and Memory

Research center

25 rue du Docteur Roux
75015 Paris
Christian Bréchot

Institution

CNRS
ED158
Université Pierre et Marie Curie

Laboratory

Genes, Synapses, Cognition
UMR 3571
Labex Revive, BioPsy

Keywords

Neural stem cells
regeneration
Olfaction
Learning
 

Publications

Sailor KA, Valley MT, Wiechert MT, Riecke H, Sun GJ, Adams W, Dennis JC, Sharafi S, Ming GL, Song H, Lledo PM. Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb. Neuron. 2016 Jul 20;91(2):384-96. doi: 10.1016/j.neuron.2016.06.004. Epub 2016 Jun 30.

Lepousez G, Nissant A, Bryant AK, Gheusi G, Greer CA, Lledo PM. Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13984-9. doi: 10.1073/pnas.1404991111. Epub 2014 Sep 4. 

Lepousez G, Lledo PM. Odor discrimination requires proper olfactory fast oscillations in awake mice. Neuron. 2013 Nov 20;80(4):1010-24. doi: 10.1016/j.neuron.2013.07.025. Epub 2013 Oct 17.


Valley MT, Henderson LG, Inverso SA, Lledo PM. Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb. J Neurosci. 2013 Sep 11;33(37):14660-5. doi: 10.1523/JNEUROSCI.2845-13.2013.

Alonso M, Lepousez G, Wagner S, Bardy C, Gabellec MM, Torquet N, Lledo PM. Activation of adult-born neurons facilitates learning and memory (2012) Nat Neurosci. May 13.

Lazarini F, Gabellec MM, Torquet N, Lledo PM. Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb. (2012) J Neurosci. Mar 14;32(11):3652-64.

Mejia-Gervacio S, Murray K, Sapir T, Belvindrah R, Reiner O, Lledo PM. MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb. (2012) Mol Cell Neurosci. Feb;49(2):97-103.

Katagiri H, Pallotto M, Nissant A, Murray K, Sassoè-Pognetto M, Lledo PM. Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit. (2011) Neural Syst Circuits. Feb 1;1(1):6.

Lepousez G, Alonso M, Wagner S, Gallarda BW, Lledo PM. Selective viral transduction of adult-born olfactory neurons for chronic in vivo optogenetic stimulation. (2011) J Vis Exp. Dec 28;(58):e3380.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

General theme: Epigenetic regulation of neuronal networks and memory

Central topic: Adult plasticity of neuronal networks
System model: The olfactory bulb for its adult neurogenesis

Research topics:

- Functional consequences of adult neurogenesis
- Diversity of adult neural stem cells
- Role of learning in olfactory preferences and aversions
- In search of memory traces following learning.
- Plasticity of inhibitory interneuron networks

ENP Students

Soham SAHA