Regulation of reward circuit and addiction by cholinergic interneurons of the nucleus accumbens
Dates:January 2, 2018 - June 29, 2018
Application deadline:June 29, 2018
~ Jan-March 2018
~ April-June 2018
The striatum regulates motor control, habits, goal directed behaviors and reward behaviors. Striatal dysfunction underlies several diseases such as Parkinson disease, obsessive-compulsive disorder and addiction. Cholinergic interneurons are major modulators of striatal function. These neurons store and release two classical neurotransmitters: ACh and glutamate (Glu). The proposed project will investigate the implication of cholinergic interneurons and co-transmission in the normal and pathological striatum.
We will focus on reward (relevant for addiction) and goal-directed behavior or habits (relevant for obsessive compulsive disorders or feeding behaviors). The project will combine mouse model and human studies (post-mortem, genetic). Technically the entire project will involve: anatomy, biochemistry, optogenetic, behavior and electrophysiology. The rotation will include: i) mutant mouse characterization, ii) in vivo electrophysiological recording and iii) human genetic. In vivo Electrophysiology will be done in collaboration with Philippe Faure Team and Human Genetic with the team of Stéphane Jamain.
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