Neuron-Glia Interactions

Leader

Research center

45 rue des Saints Pères
75006 Paris
Daniel Zytnicki

Institution

Inserm
Université Paris Descartes
ED 157 Bio SPC
Université Paris Descartes

Laboratory

Neurophysiology & New Microscopies Laboratory
Phone: 01 42 86 41 54
U1128
Idex Université Sorbonne Paris Cité

Keywords

Glial cells
Microglia
neuronal activity
astrocyte
synapse
Epilepsy
postnatal development
 

Publications

Shen W*, Nikolic L*, Meunier C, Pfrieger F, Audinat E (2017) An autocrine purinergic signaling controls astrocyte-induced neuronal excitation. Scientific reports Sep 12;7(1):11280. doi: 10.1038/s41598-017-11793-x

 

Mosser C-A, Baptista S, Arnoux I, Audinat E (2017) Microglia in CNS development: shaping the brain for the future. Progress in Neurobiology  149-150: 1-20

Carrillo-de Sauvage MA, Pasco M, Arnoux I, Maatouk L, Sanz Diez A, Delahaye M, Herrero MT, Newman TA, Calvo CF, Audinat E, Tronche F, Vyas S (2013) Potent and multiple regulatory and anti-inflammatory actions of microglial glucocorticoid receptors during inflammation. Cell Death and Differentiation 20(11): 1546-1557

Ulmann L, Levavasseur F, Avignone E, Hibec H, Audinat E*, Rassendren f* (2013) Involvement of  P2X4 receptors in hippocampal microglia activation after status epilepticus. Glia 61(8): 1306-19

Hoshiko M, Arnoux I, Avignone E, Yamamoto N, Audinat E (2012) Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamo-cortical synapses in the barrel cortex. The Journal of Neuroscience 32: 15106-15111 

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our research focuses on the interactions between neurons and glial cells in the central nervous system of rodents. Glial cells are engaged in bi-directional interactions with neurons and contribute actively to the modulation of neuronal network activities. Three main research programs structure the current activity of the team. The first one concerns the astrocytic control of neuronal activity. We have demonstrated that astrocytes synchronize the activity of neuron ensembles by releasing glutamate and GABA.

We currently study whether these two gliotransmitters are released by a single or by different populations of astrocytes. The second project is on the functional analysis of NG2-expreessing glial cells. This project supervised by Maria Cecilia Angulo aims at understanding how synaptic activity influences the fate of NG2 cells. Finally, we also study the functional properties of microglial cells in different physiological and pathological conditions to understand how these immune resident cells interact with neurones.