Neuron-Glia Interactions

Leader

Research center

45 rue des Saints Pères
75006 Paris
Daniel Zytnicki

Institution

Inserm
CNRS
Université Paris Descartes
ED 157
Université Paris Descartes

Laboratory

Neurophysiology & New Microscopies Laboratory
Phone: 01 42 86 41 54
U1128
Idex Université Sorbonne Paris Cité

Keywords

Glial cells
Microglia
neuronal activity
astrocyte
synapse
Epilepsy
postnatal development
Available to host a PhD student

Publications

Rassendren F, Audinat E. Purinergic signaling in epilepsy. J Neurosci Res. 2016 Sep;94(9):781-93. doi: 10.1002/jnr.23770. Epub 2016 Jun 14. Review.

// Arnoux I#, Hoshiko M#, Sanz Diez A#, Audinat E# (2014) Paradoxical effects of minocycline in the developing mousesomatosensory cortex. Glia 62(3): 399-410
Balia M, Vélez-Fort M, Passlick S, Schäfer C, Audinat E#, Steinhäuser C, Seifert G, Angulo MC (2014) Postnatal down-regulation ofthe GABAA receptor ?2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in GABAergic transmissionmode. Cerebral Cortex (In press)

// Carrillo-de Sauvage MA, Pasco M, Arnoux I#, Maatouk L, Sanz Diez A#, Delahaye M, Herrero MT, Newman TA, Calvo CF, AudinatE#, Tronche F, Vyas S (2013) Potent and multiple regulatory and anti-inflammatory actions of microglial glucocorticoid receptorsduring inflammation. Cell Death and Differentiation 20(11): 1546-1557

// Arnoux I#, Hoshiko M#, Avignone E#, Mandavy L#, Yamamoto M, Audinat E# (2013) Adaptive phenotype of microglial cells duringthe normal postnatal of the somatosensory "barrel" cortex. Glia 61(10): 1582-94

// Ulmann L, Levavasseur F#, Avignone E#, Hibec H, Audinat E#*, Rassendren f* (2013) Involvement of P2X4 receptors inhippocampal microglia activation after status epilepticus. Glia 61(8): 1306-19

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our research focuses on the interactions between neurons and glial cells in the central nervous system of rodents. Glial cells are engaged in bi-directional interactions with neurons and contribute actively to the modulation of neuronal network activities. Three main research programs structure the current activity of the team. The first one concerns the astrocytic control of neuronal activity. We have demonstrated that astrocytes synchronize the activity of neuron ensembles by releasing glutamate and GABA.

We currently study whether these two gliotransmitters are released by a single or by different populations of astrocytes. The second project is on the functional analysis of NG2-expreessing glial cells. This project supervised by Maria Cecilia Angulo aims at understanding how synaptic activity influences the fate of NG2 cells. Finally, we also study the functional properties of microglial cells in different physiological and pathological conditions to understand how these immune resident cells interact with neurones.