Brain-Machine Interface based on operant conditioning of neural activity in the head-fixed mouse
Dates:January 2, 2018 - June 29, 2018
Application deadline:June 29, 2018
~ Jan-March 2018 (to be discussed)
~ April-June 2018
Our team is interested in neuronal mechanisms of sensory processing and learning in the sensorimotor whisker system of the rodent. This project focuses on the impact of somatosensory feedback in learning a motor task, using a Brain-Machine Interface set-up. Recently, we have demonstrated that operant conditioning of the firing rate of a single cortical neuron is a successful strategy to control an actuator bringing a reward to the rat mouth (Arduin et al, 2013, J Neurosci). We have now built a new setup incorporating sensory feedback in the control loop of the neuroprosthesis, by stimulating optogenetically neurons in the barrel cortex of the head-fixed mouse. We have just started investigating whether the performance of the animals is improved when somatosensory feedback is provided to the brain-machine interface, in particular when we apply biomimetic patterns similar to natural spatio-temporal sequences of whisker movements. The student will be involved in training the animals and analyzing electrophysiology data from the operant conditioning task.
Unité de Neurosciences Information et Complexité (UNIC) - 1 Avenue de la Terrasse, Bât. 33, 91198 Gif-sur-Yvette, France - +33 1 69 82 34 46 - Valerie.Ego-Stengel@unic.cnrs-gif.fr