Neural Circuits and Behaviour

Research center

11 place Marcelin Berthelot
75231 Paris
Serge Haroche

Institution

Collège de France
CNRS
Inserm
ED158
Université Pierre et Marie Curie

Laboratory

Centre Interdisciplinaire Recherche Biologie
UMR7241 U1050
Labex MemoLife

Keywords

behavior
Olfactory processing
mouse genetics
imaging
Available to host a PhD student

Publications

Diodato A, Ruinart de Brimont M, Yim YS, Derian N, Perrin S, Pouch J, Klatzmann D, Garel S, Choi GB,Fleischmann A. Molecular signatures of neural connectivity in the olfactory cortex. Nat Commun. 2016 Jul 18;7:12238. doi: 10.1038/ncomms12238.

Fleischmann A, Abdus-Saboor I, Sayed A, Shykind B (2013) Functional Interrogation of an Odorant Receptor Locus Reveals Multiple Axes of Transcriptional Regulation. PLoS Biol 11(5): e1001568. doi:10.1371/journal.pbio.1001568 

K. Angelo, D. Pimentel, B. Pichler, A. Fleischmann, E. Rancz & T. Margrie , A biophysical signature of network affiliation and sensory processing in mitral cells. Nature, Aug16;488(7411):375-8.(2012)

Glinka M.E., Samuels B.A., Teillon J., Mei D.F., Shykind B.M., Hen R. & Fleischmann A., Olfactory deficits cause anxiety-like behaviors in mice. J. Neurosci., 32(19):6718-6725 (2012)

Choi G.B., Stettler D.D., Kallman B.R., Bhaskar S.T., Fleischmann A. & Axel R. (2011), Driving opposing behaviors with ensembles of piriform neurons. Cell146:1004-1015

Fleischmann A., Shykind B.M., Sosulski D.L., Franks K.M, Glinka M.E., Mei D.F., Yonghua S., Kirkland J., Mendelsohn M., Albers M.W. & Axel R., Mice with a "monoclonal" nose: perturbations in an olfactory map impair odor discrimination.Neuron. Dec 26; (60):1-14.  (2008)

Fleischmann A., Jochum W., Eferl R., Witowsky J. & Wagner E.F., Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell.Dec;4(6):477-82. (2003) 

 

Fields of research

Neurogenetics / neurodevelopment

Research Theme

My laboratory is interested in the functional properties of neural circuits underlying odor perception. We use a combination of molecular genetic, in vivo imaging and behavioral approaches in mice to understand the logic of odor coding in higher olfactory centers in the cortex.

Odor perception involves the recognition of odorants in the periphery and central mechanisms in the brain that allow the discrimination of odors and appropriate behavioral responses. Odorants are recognized by odorant receptors, expressed in olfactory sensory neurons in the nose. Odors activate subsets of sensory neurons and result in sparse and spatially invariant pattern of glomerular activity in the olfactory bulb, the first processing center of olfactory information in the brain. Information encoded by glomerular activity is then transmitted to higher olfactory centers in the cortex, which are thought to link odor representations to appropriate behavioral responses.

            Central to understanding olfactory processing is the elucidation of the functional properties of the underlying neural circuits. In an effort to address this fundamental problem in sensory biology, we have altered the patterns of neural activity evoked by odors, by generating transgenic mice in which 95% of all sensory neurons express the same receptor. Two-photon imaging and behavioral analyses of these transgenic mice suggest a model of olfactory processing in which the recognition of patterns of neural activity, or contrast, is critical for odor detection. To test this model, we exploit a set of defined genetic perturbations in transgenic mice, which alter the expression of odorant receptor genes.