Interventional neuropsychology

Research center

8 rue du général Sarrail
94011 Créteil
Jorge Boczkowski

Institution

Inserm
Université Paris-Est Créteil

Laboratory

Laboratoire de Neuropsychologie Interventionnelle
Phone: + 33 1 49 81 37 93
U955
Labex IEC: Institut d'Etude de la Cognition, Infrastructure nationale en biologie et santé: PROJET NeurATRIS

Keywords

cognitive functions
therapie génique
Maladie de Huntington
Maladie de Parkinson
greffe
Available to host a PhD student

Publications

Teichmann M, Rosso C, Martini JB, Bloch I, Brugières P, Duffau H, Lehéricy S, Bachoud-Lévi AC. A cortical-subcortical syntax pathway linking Broca's area and the striatum. Hum Brain Mapp. 2015 Feb 16. doi: 10.1002/hbm.22769.

1. Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H,Lefaucheur JP, Thiriez C, #Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P,Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA,Hantraye P, Remy P, #Cesaro P, Mitrophanous KA. Long-term safety and tolerability of ProSavin, a lentiviral vector-based genetherapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet. 2014 Mar 29;383(9923):1138-46.

2. #Jacquemot, C., Dupoux, E & #Bachoud-Lévi, A-C. (2011). Is the word length effect linked to subvocal rehearsal ? Cortex, 47 pp.484-493

3. #Cleret de Langavant, L.,# Jacquemot, C., #Bachoud-Lévi, A-C. & Dupoux, E. (2013). The second person in «I» - «you» - «it»triadic interactions. Behavioral and Brain Sciences. 36(4):416-7

4. #Fénelon G, Soulas T, Zenasni F, #Cleret de Langavant L. The changing face of Parkinson's disease-associated psychosis: Across-sectional study based on the new NINDS-NIMH criteria. Mov Disord, 2010, 25: 763-6.

5. #Fénelon G, Soulas T, #Cleret de Langavant L, Trinkler, I, #Bachoud-Lévi A-C. Feeling of presence in Parkinson’s disease, JNeurol Neurosurg Psychiatry, 2011, 82: 1219-24.6. Trinkler I, #Cleret de Langavant L, #Bachoud-Lévi

Fields of research

Cognitive neurosciences / neuropsychology /neuroeconomy

Research Theme

Our team is built at the interface between basic research in cognition and clinical research in brain therapies.

We address two questions:

1) the bases of specifically human cognitive functions (language and social cognition), and the role of the striatum in such functions;

2) the relation between brain reconstruction and functional reconstruction (rehabilitation and grafting). Because Huntington's Disease is predominantly characterized by a neural degeneration targeting the striatum, we used it as a model both for striatal lesion and for cell therapy and neuroprotection. We combine large scale studies in cell therapy and basic research in cognition.

This specificity enables us for the first time to use intracerebral grafting as a model of plasticity in human beings and to integrate therapeutics in basic research in cognition. In addition, we develop cognitive programs in language and social cognition within the Département d’Etudes Cognitives (ENS) and transfer them to brain pathology.

Team members

Gilles Fenelon
Charlotte Jacquemot
Laurent Cléret
Katia YOUSSOV