Imaging and Psychiatry

Research center

4, place du Général Leclerc
91401 Orsay

Institution

Inserm
CEA
ED158
Université Paris Saclay / Université Paris Descartes

Laboratory

Laboratoire Imagerie et Psychiatrie
U1000
IHU Necker

Keywords

Depression
schizophrenia
autism
Brain imaging
addiction
Available to host a PhD student

Publications

Dubol M, Trichard C, Leroy C, Sandu AL, Rahim M, Granger B, Tzavara ET, Karila L, Martinot JL, Artiges E. Dopamine Transporter and Reward Anticipation in a Dimensional Perspective: A Multimodal Brain Imaging Study. Neuropsychopharmacology. 2017 Aug 22. doi: 10.1038/npp.2017.183. [Epub ahead of print]

Stringaris A,. Martinot JL*, Schumann G*, Paillère-Martinot ML* & the IMAGEN Consortium. The brain’s response to reward anticipation and depression in adolescence: dimensionality, specificity and longitudinal predictions in a community-based sample. American Journal of Psychiatry 2015 Dec;172(12):1215-23.

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry 2014, 19(4):462-70.

Sandu AL, Artiges E, Galinowski A, Gallarda T, Bellivier F, Lemaitre H, Granger B, Ringuenet D, Tzavara ET, Martinot JL, Paillère Martinot ML. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017 Aug 9. doi: 10.1002/da.22675. [Epub ahead of print]

Artiges E, Leroy C, Dubol M, Prat M, Pepin A, Mabondo A, de Beaurepaire R, Beaufils B, Korwin JP, Galinowski A, D'Albis MA, Santiago-Ribeiro MJ, Granger B, Tzavara ET, Martinot JL, Trichard C. Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study. Schizophr Bull. 2017 Feb 8. doi: 10.1093/schbul/sbw192

 

Fields of research

Neurological and psychiatric diseases

Research Theme

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

- Autism: Deficits in brain anatomy and function of the temporal cortex in children with autism have been observed, and these deficits have been related to the severity of their social impairment.

- Schizophrenia: Differences in cortical gyrification and function, notably in the left temporal region, has been observed in schizophrenic patients with pharmaco-resistant auditory hallucinations. 

- Bipolar disorder: More white matter connectivity and grey matter activation has been observed in regions previously shown to process emotions in recovering bipolar patients. This suggests that the brain remains vulnerable to emotional cues, even in a remitted state.