Imaging and Psychiatry

Research center

4, place du Général Leclerc
91401 Orsay

Institution

Inserm
CEA
ED158
Université Paris Saclay / Université Paris Descartes

Laboratory

Laboratoire Imagerie et Psychiatrie
U1000
IHU Necker

Keywords

Depression
schizophrenia
autism
Brain imaging
addiction
Available to host a PhD student

Publications

Whelan R, et al. Neuropsychosocial profiles of current and future adolescent alcohol misusers. Nature. 2014 Aug 14;512(7513):185-9. doi: 10.1038/nature13402. Epub 2014 Jul 2. 

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry. 2013, doi: 10.1038/mp.2013.44. [Epub ahead of print]

 Müller KU, Mennigen E, Ripke S, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Fauth-Bühler M, Flor H, Garavan H, Heinz A, Lawrence C, Loth E, Mann K, Martinot JL, Pausova Z, Rietschel M, Ströhle A, Struve M, Walaszek B, Schumann G, Paus T, Smolka MN & the IMAGEN Consortium. Altered Reward Processing in Adolescents With Prenatal Exposure to Maternal Cigarette Smoking. JAMA Psychiatry. 2013, Jun 19:1-10. doi: 10.1001/jamapsychiatry.2013.44. [Epub ahead of print]

Schilling C, Kühn S, Paus T, Romanowski A, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Conrod PJ, Dalley JW,Flor H, Ittermann B, Ivanov N, Mann K, Martinot JL, Nees F, Rietschel M, Robbins TW, Smolka MN, Ströhle A, Kathmann N, Garavan H, Heinz A, Schumann G, Gallinat J; IMAGEN consortium (www.imagen-europe.com). Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence.Mol Psychiatry. 2013 May;18(5):624-30

Loth E, Poline JB,Thyreau B, Jia T, Tao C, Lourdusamy A, Stacey D, Cattrell A, Desrivieres S, Ruggeri B, Fritsch V, Banaschewski T, Barker GJ, Bokde AL, Bruehl R, Büchel C, Carvalho F, Conrod PJ, Fauth-Buehler M, Flor H, Gallinat J,Garavan H, Heinz A, Lawrence C, Mann K, Martinot JL, Nees F, Paus T, Pausova Z, Poustka L, Rietschel M, Smolka MN, Struve M, Feng J, Schumann G & the IMAGEN Consortium. Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events. Biological Psychiatry. (In press)

Nees F, Witt SH, Lourdusamy A, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Frank J, Gallinat J, Garavan H, Heinz A, Ittermann B, Loth E, Mann K, Artiges E, Paus T, Pausova Z, Smolka MN, Struve M, Schumann G, Rietschel M, Flor H & the IMAGEN Consortium. Genetic Risk For Nicotine Dependence in the Cholinergic System and Activation of the Brain Reward System in Healthy Adolescents. Neuropsychopharmacology. 2013, May 21. doi:10.1038/npp.2013.131. [Epub ahead of print]



Fields of research

Neurological and psychiatric diseases

Research Theme

Over the past 4 years, we have been studying psychiatric disorders and addictions that are prevalent and have a high social cost. We use magnetic resonance imaging and positron emission tomography to capture brain images in severely impaired patients and to assess the effects of treatment on brain function. We are based in the Service Hospitalier Frédéric Joliot (SHFJ), Orsay. We also collaborate with a network of psychiatrists within the Paris area and collaborate on large data sets with North Europe research teams.

 

PATHOPHYSIOLOGY

- Autism: Deficits in brain anatomy and function of the temporal cortex in children with autism have been observed, and these deficits have been related to the severity of their social impairment.

- Schizophrenia: Differences in cortical gyrification and function, notably in the left temporal region, has been observed in schizophrenic patients with pharmaco-resistant auditory hallucinations. 

- Bipolar disorder: More white matter connectivity and grey matter activation has been observed in regions previously shown to process emotions in recovering bipolar patients. This suggests that the brain remains vulnerable to emotional cues, even in a remitted state.