Hindbrain Integrative Neurobiology

Leader

Research center

Bâtiment 145, Centre d'études de Saclay
91191 Gif sur Yvette
Philippe Vernier

Institution

CNRS
Université Paris Sud
ED 568 BioSigNe
Université Paris Sud 11

Laboratory

Neurobiologie et Développement
Phone: 06 18 35 80 54
UMR9197
Idex NeuroSaclay, EQUIPE X "MORPHOSCOPE 2"

Keywords

Behaviour
Development
Breathing
Neural circuit
Rhythm generation
Mouse embryo
Available to host a PhD student

Publications

Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O. Nature. 2013;500:85-88.

Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. Journal of Neuroscience. 2011;31:12880-8.

Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A, Fortin G. Nature Neuroscience. 2010;13:1066-74.

Thoby-Brisson M KM, Wu N, Charnay P, Champagnat J, Fortin G. Nature Neuroscience. 2009;12(8):1028-1035.

Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G. Journal of Neuroscience. 2005;25:4307-4318.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The intrinsic logic of neural networks controlling defined circuit functions and behaviours in the central nervous system is a fundamental issue of neuroscience. We study the central control of breathing, a classical model system to (i) perform integrative neurobiology and (ii) extend the significance of developmental biology, beyond anatomical organization to the level of network assembly and function.

Focusing on the inception of this circuit, we are identifying in the mouse embryo, the progenitor domains that give rise to distinct components of the network that have a vital fate. We are using developmental genetics tools, to fate map, follow the migration, impair the connectivity, invalidate and actuate selective neuronal populations in the circuit, to derive the operating principles, provide constituent cells with molecular identities and reveal early pre-disposition to dysfunctions. We intend to make sense of cellular identities now investigating cells’ functional and anatomical connectivities respectively, by optogenetics combined to phase modulation of optical wave-fronts, and by monosynaptic viral tracing.

ENP Students

Jinjin WU

Lab rotation

Respiratory Network Connectivity

Team leader: 

FORTIN Gilles

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

Our project is to investigate the importance of homotypic synapses (i.e. that connect neurons sharing a common subtype identity) in the brainstem network that controls breathing. This project will make use of trans-synaptic viral tracing methods and intersectional mouse genetics.

Contact

Neuro-PSI - Bat 32, 1 avenue de la terrasse 91190 Gif sur Yvette - gilles.fortin@cnrs.fr

Supervisor: 

FORTIN Gilles