Genes Circuits Rhythms and Neuropathology

Leader

Institution

CNRS
ESPCI
ED 158 3C
Université Pierre et Marie Curie

Laboratory

Laboratoire Plasticité du cerveau
UMR 8249
Labex MemoLife, Idex PSL

Keywords

Parkinson’s disease
dopamine
Neurodegeneration
Locomotor aging
Drosophila models
Available to host a PhD student

Publications

Cassar M.#, Issa A.-R.#, Riemensperger T.#, Petitgas C.#, Rival T.#, Coulom H.#, Iché-Torres M.#, Han K.-A. & Birman S#. (2015)A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T.#, Birman S.#, Stensmyr M. C. & Hansson B. S. (2014) Dopamine drivesDrosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T.#, Issa A.-R.#, Pech U., Coulom H.#, Nguy?n M.-V.#, Cassar M.#, Jacquet M.#, Fiala A. & Birman S#. (2013) Asingle dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Pech U., Pooryasin A., Birman S#. & Fiala A. (2013) Visualization of the connections between Kenyon cells and aminergic neuronsin the Drosophila melanogaster brain using split-GFP reconstitution. J. Comp. Neurol. 521(17):3992-4026

Reinhardt A., Feuillette S., Cassar M.#, Callens C.#, Thomassin H., Birman S.#, Lecourtois M., Antoniewski C. & Tricoire H. (2012)Lack of miRNA misregulation at early pathological stages in Drosophila neurodegenerative disease models. Front. Genet. 3:226

Fields of research

Neuropharmacology / cell signaling

Research Theme

Our research program aims at understanding how the brain controls locomotor activity, and how aging or neurodegenerative pathologies, such as Parkinson’s disease and amyotrophic lateral sclerosis, alter this function and in general brain functioning. We try to identify neuronal networks controlling locomotor activity and circadian mechanisms that modulate them in health and disease. Our approach combines genetics methods, brain imaging and behavioral assays. We use the fruit fly Drosophila melanogaster as a model because this organism offers invaluable advantages for genetic studies. In this animal, locomotion is easily quantifiable and increasingly sophisticated tools are available to follow or modify neuronal activity in vivo. In addition, models for the main human neurodegenerative diseases, developed in other and our laboratories, are routinely studied in this organism

Team members

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun

Lab rotation

Study of neuroprotection mechanisms in Drosophila Parkinson’s disease models

Team leader: 

BIRMAN Serge

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

This project will address the implication of the autophagy-lysosome and mitochondrial biogenesis pathways and their interaction as endogenous mechanisms of neuroprotection in Parkinson’s disease using molecular, genetics and imaging methods in Drosophila.

Contact

ESPCI - 10 rue Vauquelin 75005 Paris - +33 1 40 79 58 35 - serge.birman@espci.fr

Supervisor: 

BIRMAN Serge or CHERIF-ZAHAR Baya