Gabaergic synapses in the cerebellum

Leader

Research center

45 rue des Saints Pères
75006 Paris
Daniel Zytnicki

Institution

CNRS
Université Paris Descartes
Université Paris Descartes / Université Paris Diderot

Laboratory

Brain Physiology Lab
Phone: 01 42 86 38 36
UMR 8118

Keywords

Patch clamp
cellular imaging
electrophysiology
Available to host a PhD student

Publications

Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A. Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis. Neuron. 2016 Aug 17;91(4):808-23. doi: 10.1016/j.neuron.2016.07.033.

Pulido C, Trigo FF, Llano I, Marty A. Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses. Neuron. 2015 Jan 7;85(1):159-72. doi: 10.1016/j.neuron.2014.12.006. Epub 2014 Dec 24.


Alcami P, Marty A. Estimating functional connectivity in an electrically coupled interneuron network. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4798-807. doi: 10.1073/pnas.1310983110. Epub 2013 Nov 18.

Lamotte d'Incamps B, Krejci E, Ascher P (2012) Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-renshaw cell synapse. J. Neurosci 32:8413-8423

Mejia-Gervacio, S. V. (2012). Muscarinic control of AMPA receptor responsiveness in mouse spinal cord motoneurons. J. Physiol. in press.

Palma-Cerda F, Auger C, Crawford DJ, Hodgson ACC, Reynolds SJ, Cowell JK, Swift KAD, Cais O, Vyklicky L, Corrie JET, Ogden D (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology 63:624-634

Pessac B, Nimmagadda VK, Makar T, Fishman PS, Bever CT, Trisler D (2012) Adult hematopoietic progenitors are multipotent in chimeric mice. C. R. Biol 335:454-462

Rossi B, Ogden D, Llano I, Tan YP, Marty A, Collin T (2012) Current and Calcium Responses to Local Activation of Axonal NMDA  Receptors in Developing Cerebellar Molecular Layer Interneurons. PLoS One 7 7(6): e39983



Fields of research

Neuropharmacology / cell signaling

Research Theme

This team employs a multidisciplinary approach including physical methods (optics), mathematical methods (statistical treatment of data and modelling) as well as chemical methods (synthesis of new compounds). It develops new techniques to study intercellular communication in the brain tissue. Currents lines of research concern the role of internal calcium stores in pre- and postsynaptic signalling; the functional implication of endogenous calcium buffers in presynaptic calcium signalling; the role of ionotropic presynaptic receptors in the regulation of the firing pattern and of the release probability.

Team members

David Ogden
Isabel Llano