Dynamical Neural Theory Group

Leader

Co-Leaders

Research center

45 rue d’Ulm
75230 Paris
Marc Mézard

Institution

Ecole Normale Supérieure
Inserm

Laboratory

Laboratoire de Neurosciences Cognitives
U960
IEC, PSLP

Keywords

Learning
Synaptic plasticity
computational neuroscience
cognitive decision processes
neuronal architectures
drug addiction
short-term memory
decision-making
Available to host a PhD student

Publications

Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS. Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J Neurosci. 2016 Nov 16;36(46):11619-11633.

Keramati M, Gutkin B. Homeostatic reinforcement learning for integrating reward collection and physiological stability. Elife. 2014 Dec 2;3. doi: 10.7554/eLife.04811.

Caze, R.D., Humphries, M., and Gutkin, B.S., Passive Dendrites Enable Single Neurons to Compute Linearly Non-separableFunctions, PLOS Computational Biology, 9(2): e1002867, (2013).

Keramati, M. and Gutkin, B.S., Imbalanced decision hierarchy in addicts emerging from drug-hijacked dopamine spiraling circuit,PLOS One, 8:4, 1-8 (2013).

Lochmann, T., Ernst, U.A., and Denève, S., Perceptual inference predicts contextual modulations of sensory responses, Journal of Neuroscience, 32(12), 4179-95 (2012).

Tolu, S., Eddine, R., Marti, F., David, V., Graupner, M., Baudonnat, S.P.M., Besson, M., Reperant, C., Zemdegs, J., Pages, C., Caboche, J., Gutkin, B., Gardier, A.M., Changeux, J., Faure, P., and Maskos, U., Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement., Molecular Psychiatry, in press, (2012).

DiPoppa, M., Krupa, M., Torcini, A., and Gutkin, B., Marginally Stable States and Quasi-periodic minor attractors in excitable pulse-coupled networks, SIAM Journal of Applied Dynamical Systems, 11, 864 894 (2012).

Deneve, S., Making decisions with unknown sensory reliability, Frontiers in Neuroscience, 6:75, doi: 10.3389/fnins.2012.00075 (2012).

Jardri, R. and Deneve, S., Computational models of hallucinations., The Neuroscience of Hallucinations, (2012).

Fields of research

Computational neurosciences / neural theory

Research Theme

The goal of the GNT is to understand the basis of information processing in the brain by identifying links between collective neural dynamics and function. Research in the group comprises a broad spectrum of different topics in Computational Neuroscience, including network models of working memory, drug addiction models, probabilistic inference, feature integration, and statistical learning in neuronal architectures, spike-based learning algorithms, and mean-field analysis of recurrent networks, modeling of short-term plasticity in synaptic transmission and dynamics of GABA neurotransmission.

The work is based on methods form computational neuroscience, mathematics, statistics, computer science and physics: e.g. dynamical systems, Bayesian statistics, machine learning, statistical data analysis, stochastic differential equations, compartmental modelling, and mean field methods.

The interns will have a opportunity to take part in a wide range of research projects within the sub-teams of the three PIs: Boris Gutkin, Christian Machens and Sophie Deneve.  The Group for Neural Theory has was founded in 2005 as a part of the Départment d'Etudes Cognitives (DEC) at Ecole Normale Supérieure (ENS). The group is now part of the Laboratoire de Neurosciences Cognitives (LNC, INSERM Unité 960) within the DEC at the ENS.

ENP Students

Flora BOUCHACOURT

Lab rotation

Computational psychiatry of drug addiction

Team leader: 

GUTKIN Boris

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

We propose a project focused on computational modelling of effects of addictive drugs on the circuits in the dopaminergic and fronto-cortical brain systems. The specific project for the rotation will be designed together with the students, and will be a part of the ongoing effort in the team. Possible specific topics include: computational modelling of nicotine and alcohol interactions, effects of alcohol on goal representations in the pre-frontal cortex, effects of addictive drugs on the interplay between homeostatic control and motivation.

Contact

Ecole Normale Supérieure - Laboratoire de Neurosciences Cognitives - 29 rue d'Ulm 75005 Paris - +33 1 44 32 29 56 - boris.gutkin@gmail.com

Supervisor: 

GUTKIN Boris