Computational Neuroscience

Leader

Research center

1 avenue de la Terrasse1 avenue de la Terrasse
91190 Gif-sur-Yvette
Yves Frégnac

Institution

CNRS
Université Paris Sud
ED158 - 3C
Université Pierre et Marie Curie

Laboratory

Phone: 33-1-69-82-34-35
UPR 3293
IDEX NeuroSaclay

Keywords

high-conductance state
in vivo
dynamic-clamp
computational models
Available to host a PhD student

Publications

Destexhe, A. and Contreras, D. Neuronal computations with stochastic network states. Science 314: 85-90, 2006.

Brette, R., Piwkowska, Z., Monier, C., Rudolph-Lilith, M., Fournier, J., Levy, M., Fregnac, Y., Bal, T. and Destexhe, A. High-resolution intracellular recordings using a real-time computational model of the electrode.  Neuron 59: 379-391, 2008.

Marre, O., El Boustani, S., Fregnac, Y. and Destexhe, A. Prediction of spatio-temporal patterns of neural activity from pairwise correlations.  Physical Review Letters 102: 138101, 2009.

Destexhe A. Intracellular and computational evidence for a dominant role of internal network activity in cortical computations.   Current Opinion Neurobiol.  21: 717-725, 2011.

Peyrache A, Dehghani N, Eskandar EN, Madsen JR, Anderson WS, Donoghue JS, Hochberg LR, Halgren E, Cash SS and Destexhe A.   Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep.  Proc. Natl. Acad. Sci. USA 109: 1731-1736, 2012.

Estebanez L, El Boustani S, Destexhe A and Shulz D.  Correlated input reveals coexisting coding schemes in a sensory cortex. Nature Neuroscience 15: 1691-1699, 2012.

Bedard, C. and Destexhe, A.  Generalized cable theory for neurons in complex and heterogeneous media.  Physical Review E 88: 022709, 2013.

Muller LE, Reynaud A, Chavane F and Destexhe A.  The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave. Nature Communications 5: 3675, 2014.

Reig, R., Zerlaut, Y., Vergara, R., Destexhe, A.  and Sanchez-Vives, M. Gain modulation of synaptic inputs by network state in auditory cortex in vivo.  J. Neurosci. 35: 2689-2702, 2015.

Le Van Quyen M, Muller LE 2nd, Telenczuk B, Halgren E, Cash S, Hatsopoulos NG, Dehghani N, Destexhe A. High-frequency oscillations in human and monkey neocortex during the wake-sleep cycle. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9363-8. doi: 10.1073/pnas.1523583113. Epub 2016 Aug 1.

Fields of research

Computational neurosciences / neural theory

Research Theme

Integrative properties of neocortical neurons in high-conductance states.
In awake animals, neurons of cerebral cortex are in a "high-conductance" (HC) state, characterized by a sustained, irregular and very noisy spike discharges. Neurons have very special integrative properties during such states, in particular regarding the integration of excitatory and inhibitory inputs. Studying this complex integrative dynamics requires a tight association between in vivo, in vitro and computational techniques. HC states are measured intracellularly in vivo in anesthetized animals, and these measurements are then integrated into computational models to recreate such states numerically. These models are then used in "dynamic-clamp" in vitro experiments, in which computational models interact directly with living neurons recorded intracellularly. This back-and-forth dynamics between techniques in vivo, in vitro and in computo allows us to re-create HC states in vitro and benefit from this preparation to reconstruct the transfer ("input-output") function of the neuron during HC states. This information is necessary to understand the dynamics of information processing during active states of cerebral cortex.

ENP Students

Lyle MULLER