Cerebellum, Navigation and Memory


Research center

9 Quai Saint-Bernard Université Pierre et Marie Curie, Campus Jussieu, Bâtiments A-B-C
75005 Paris
Michel Labouesse


Université Pierre et Marie Curie


Neuroscience Paris Seine
U1130 UMR8246 UMCR18


spatial memory
spatial navigation


Selected publications

*co-last authors;

en italique: les membres passés et présents de l'équipe de recherche

Rondi-Reig L., Paradis A.L., Babayan, B, Tobin C. How cerebellum continuous sensori-motor monitoring may subserve spatial knowledge.In “Distributed networks: new outlooks on cerebellar function.” hosted by Dr(s) Matthew Jones, Thomas C Watson, Richard Apps, Stella Koutsikou in Frontiers in Neuroscience (Systems Neuroscience), 2014.

Kinga Iglói, Christian F. Doeller, Anne-Lise Paradis, Karim Benchenane, Alain Berthoz, Neil Burgess and Laure Rondi-Reig. Interaction between hippocampus and cerebellum Crus I in sequence-based but not place-based navigation. Cerebral cortex, 25(11):4146-54, 2015

de Lavilléon Gaetan, Lacroix Marie Masako, Rondi-Reig Laure*, Benchenane Karim* Explicit memory creation during sleep: a causal role of place cells in navigation. Nature Neuroscience, 18(4):493-5.

Rochefort C., Lefort J., Rondi-Reig L. (Invited Review). The cerebellum: a new key structure in the navigation system. Frontiers in neural circuit, invitation to a special issue on the cerebellum, 7:35. 2013

Cabral H.O., Vinck M., Fouquet C., Pennartz C.M.A., Rondi-Reig L., and Battaglia F.P. Oscillatory dynamics and place field maps reflect sequence and place memory processing in hippocampal ensembles under NMDA receptor control. Neuron, 81(2):402-15, 2014

 Bellassen V., Igloi K., de Souza LC., Dubois B., Rondi-Reig L.Spatio-temporal navigation as behavioral cognitive marker.  J. Neuroscience, 32(6):19421952

Rochefort C., Arnaud Arabo A., André M., Poucet B.,  Save E. and Rondi-Reig L.Cerebellum Shapes Hippocampal Spatial Code.  Science 2011 334, 385-389 Faculty of 1000: F1000.com/13357388 http://www.newscientist.com/article/dn21075-mouse-manoeuvres-in-the-  dark-reveal-brains-map-links.html 2011.

Liens vidéos:

- « les-chemins-de-l-orientation »

UNIVERSCIENCE - Cité des sciences - Sens de l’orientation ? Où ça ?

Bibliothèque Médicis  « sciences-bibliotheque-medicis_news »


Science à Coeur: http://video.upmc.fr/differe.php?collec=CS_C_sac4&video=10

Fields of research

Neurophysiology / systems neuroscience

Research Theme

We aim at understanding the neural bases of navigation and spatial memory. The principal objective of our work is to provide a comprehensive characterization of how the cerebellum participates to spatial cognition.

This contribution presumably operates, at different levels, including the computation of sensory-motor signals and a functional influence on forebrain areas supporting memory and executive functions (e.g. hippocampus and/or associative cortices).

Our research is divided in two complementary axes that we address using a translational approach both in mice obtained by conditional mutagenesis and in humans:

  • 1) Understand the dynamics of the brain navigation network by measuring functional activity of the cerebellum and the forebrain areas during navigation.
  • 2) Develop behavioral markers to evaluate spatial cognition under pathological state (i.e. Alzheimer disease, Autism Spectrum Disorders), both in patients and mice models.

The technical strength of our project lies in the combination of multi-scale experimental techniques: in vivo electrophysiology (spikes activity and local field potential), optogenetic control of neuronal activity, brain imaging and multi-parametric analysis of complex navigation behavior, using innovative tests in real-world and virtual reality environments.

ENP Students