Central COntrol oF Feeding behaviour and Energy Expenditure (C2OFFEE)

Leader

Research center

4 rue Marie-Andrée Lagroua Weill-Hallé Université Paris Diderot UFR Sciences du Vivant
75013 Paris
Jean-Marie Dupret

Institution

Université Paris Diderot
CNRS
ED157
Université Paris Diderot

Laboratory

UMR 8251
USPC
Available to host a PhD student

Publications

Cansell C, Luquet S. Triglyceride sensing in the reward circuitry: A new insight in feeding behaviour regulation. Biochimie. 2016 Jan;120:75-80. doi: 10.1016/j.biochi.2015.07.004. Epub 2015 Jul 6.

#Denis, RG., #Joly, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S., #Cansell, C., Dehouck, B., #Castel, J., #Delbes, AS.,#Martniez, S.,#Lacombe, A., Rouch, C., Kassis, N., Fehrentz,J-A., Martinez, J, Verdié, P., #Hnasko, T, Palmiter, RD., Krashes, MJ.,Güler, A., Magnan, C., #Luquet, S (2015). Palatability can drive feeding independent of AgRP neurons. Cell Metab 22, 646-657.

Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H.L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., #Denis, R.G., Ancel,P., Lacombe, A., Ling, Y., Allatif, O., Cruciani-Guglielmacci, C., Andre, S., Viguerie, N., Poitou, C., Stich, V., Torcivia, A., Foufelle, F.,#Luquet, S., Aron-Wisnewsky, J., Langin, D., Clement, K., Udalova, I.A., and Venteclef, N. (2015). Irf5 deficiency in macrophagespromotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med 21, 610-618.

Geurts, L., Everard, A., Van Hul, M., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., #Castel, J., #Denis, R.G., Bergiers, M.,Druart, C., Alhouayek, M., Delzenne, N.M., Muccioli, G.G., Demoulin, J.B., #Luquet, S., and Cani, P.D. (2015). Adipose tissueNAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nature communications 6, 6495

Everard, A., Geurts, L., Caesar,R., Matamoros, S., Duparc, T., #Denis, R., Cochez, R., Pierard, F., #Castel, J., B. Bindels, L.,Robine,S., G. Muccioli, G., Renauld,JC., Dumoutier, L., Delzenne, N., #Luquet, S., Backhed, F., Cani, P. Intestinal epithelial MyD88 isa sensor switching host metabolism during diet induced obesity. (2014). Manuscript accepted in Nature communication.

Mouisel, E., Hourde, C., Karima Relizani, C., Mille-Hamard, L., #Denis, R., Agbulut, O., Jülich, K., Arandel, L., Vignaud, A., Garcia,L., Ferry, A., #Luquet, S., Billat, V., Bendahan Ventura-Clapier, R., Schuelke, M., and Amthor, H. (2014). Myostatin is a key mediatorbetween energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol 307, R444-454.(IF2014: 3.106)

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The modern abundance of energy-rich foods combined with a shift to more sedentary lifestyles has led to a thermodynamic imbalance, and consequently, excessive caloric intake and reduced energy expenditure are the main causes for the prevalence of obesity. According to the World Health Organization (WHO) the obesity worldwide obesity has more than doubled since 1980. In 2008, 1.5 billion adults, 20 and older, were overweight. Obesity is now also considered as an epidemic by the French Health system. A recent report from the French SENAT pinpoints the dramatic progression of obesity in France and a « Plan Obésité » has been launched in 2011 under the highest authorities. According to the WHO, the fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. And it is a fact that globally, there has been both an increased intake of energy-dense foods that are high in fat, salt and a decrease in physical activity. In adult mammals energy homeostasis is finely regulated. Blood glucose levels, body weight, and fat content remain within narrow ranges and experimentally-induced perturbations (e.g., food restriction) invariably result in a rapid return to ‘set point’ when normal conditions are restored.

To accomplish this, circulating peripheral factors such as hormones (e.g., insulin, leptin, ghrelin) and nutrients (e.g., glucose, lipids) activate discrete neural circuits in the brain that trigger changes in the basal metabolic rate and/or feeding behaviour. Disruption of these neural circuits can give rise to life-threatening conditions that include metabolic diseases such as obesity and diabetes in both humans and rodent models. Therefore it is crucial to understand the mechanism that insures the proper equilibrium between energy intake and expenditure. The core approach of the COFFEE team is to leverage the power of modern molecular genetic tools and mouse models in integrated approaches in order to dissect out the role of discrete neural circuit elements in the control of different aspect of energy balance including feeding behavior notably in its rewarding & motivational component together with energy expenditure and nutrient partitioning.

Team members

Julien Castel
Raphaël Denis
Claire Martin
Mar Quiñones Téllez
Anne-Sophie Delbes
Chloé Berland
Olja Kacanski

Lab rotation

Neuronal networks and feeding behavior

Team leader: 

LUQUET Serge

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

Smell plays a key role in food choice and consumption. Despite this evidence, the functional relation between the olfactory system and the hypothalamus is largely unknown. Using in vivo electrophysiology (local field potential recordings) in behaving mice, we aim at unraveling the functional coupling between these two regions taking advantage of behavioral approaches (food-driven and olfactory-conditioned tasks) and pharmacogenetics tools (DREADDs). Importantly, the integrity of the network will be compared between lean and obese animals. 

Contact

Unité Biologie Fonctionnelle & Adaptative - 4, rue Marie-Andrée Lagroua Weill-Hallé - Bâtiment Buffon, Case courrier 712675205 Paris Cedex 13 - + 33 1 57 27 77 93 - claire.martin@univ-paris-diderot.fr

Supervisor: 

MARTIN Claire