Central COntrol oF Feeding behaviour and Energy Expenditure (C2OFFEE)


Research center

4 rue Marie-Andrée Lagroua Weill-Hallé Université Paris Diderot UFR Sciences du Vivant
75013 Paris
Jean-Marie Dupret


Université Paris Diderot
Université Paris Diderot


UMR 8251
USPC, collaborative ANR 2016


Garcia-Caceres, C., Quarta, C., Gao, Y., Varela, L., Gruber T, Legutko, B., Jastroch M., Johansson, P., Ninkovic J, Yi, CX., Le Thuc O, Meyer, C., Pfluger, PT., Fernandez AM., Luquet, S., Woods SC., Torres-Alemán, I., Kahn, C.R., Götz, M., Horvath, TL. & Tschöp, MH*. (2016) Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell 166, 867-880. (IF 2015:32.857)

 Denis, RG., Joly, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S., Cansell, C., Dehouck, B., Castel, J., Delbes, AS., Martinez, S.,Lacombe, A., Rouch, C., Kassis, N., Fehrentz,J-A., Martinez, J, Verdié, P., Hnasko, T, Palmiter, RD., Krashes, MJ., Güler, A., Magnan, C., Luquet, S (2015). Palatability can drive feeding independent of AgRP neurons. Cell Metab 22, 646-657. (IF 2015 :17.897)

Sun, X., Luquet, S., Small, DM. (2017). DRD2: Bridging the genome and ingestive behavior. Trends in Cognitive Sciences. Trends Cogn Sci 21, 372-384.. (IF 2015:17.85)

 Geurts, L., Everard, A., Van Hul, M., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., Castel, J., Denis, R.G., Bergiers, M., Druart, C., Alhouayek, M., Delzenne, N.M., Muccioli, G.G., Demoulin, J.B., Luquet, S., and Cani, P.D. (2015). Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nature communications 6, 6495 (IF2015: 12.00)

Cansell, C., Castel, J., Denis, R., Rouch, C., Delbes, AS., Martinez, S., Mestivier, D., Finan, B., Maldonado-Aviles, J.G, Rijnsburger, M.,  Tschöp, M.H., DiLeone, R.J., Eckel, R.H., La Fleur, S., Magnan, C., Hnasko, T., Luquet., S (2014). Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry 19, 1095-1105. (IF2015: 13.314)

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The modern abundance of energy-rich foods combined with a shift to more sedentary lifestyles has led to a thermodynamic imbalance, and consequently, excessive caloric intake and reduced energy expenditure are the main causes for the prevalence of obesity. According to the World Health Organization (WHO) the obesity worldwide obesity has more than doubled since 1980. In 2008, 1.5 billion adults, 20 and older, were overweight. Obesity is now also considered as an epidemic by the French Health system. A recent report from the French SENAT pinpoints the dramatic progression of obesity in France and a « Plan Obésité » has been launched in 2011 under the highest authorities. According to the WHO, the fundamental cause of obesity and overweight is an energy imbalance between calories consumed and calories expended. And it is a fact that globally, there has been both an increased intake of energy-dense foods that are high in fat, salt and a decrease in physical activity. In adult mammals energy homeostasis is finely regulated. Blood glucose levels, body weight, and fat content remain within narrow ranges and experimentally-induced perturbations (e.g., food restriction) invariably result in a rapid return to ‘set point’ when normal conditions are restored.

To accomplish this, circulating peripheral factors such as hormones (e.g., insulin, leptin, ghrelin) and nutrients (e.g., glucose, lipids) activate discrete neural circuits in the brain that trigger changes in the basal metabolic rate and/or feeding behaviour. Disruption of these neural circuits can give rise to life-threatening conditions that include metabolic diseases such as obesity and diabetes in both humans and rodent models. Therefore it is crucial to understand the mechanism that insures the proper equilibrium between energy intake and expenditure. The core approach of the COFFEE team is to leverage the power of modern molecular genetic tools and mouse models in integrated approaches in order to dissect out the role of discrete neural circuit elements in the control of different aspect of energy balance including feeding behavior notably in its rewarding & motivational component together with energy expenditure and nutrient partitioning.

Team members

Julien Castel
Raphaël Denis
Claire Martin
Mar Quiñones Téllez
Anne-Sophie Delbes
Chloé Berland
Olja Kacanski