Thyroid dysfunction and Alzheimer’s disease
Dates:September 1, 2016 - June 30, 2017
Application deadline:September 1, 2016
Lab rotation proposal:
~ Sep-Dec 2016 (maybe) ~ Jan-March 2017 ~ Apr-June 2017
Factors impacting the risk of developing sporadic forms of Alzheimer’s disease (AD), which accounts for over 99% of the cases, remain poorly understood. Hypothyroidism, which becomes more prevalent with advancing age, is a risk factor for AD. We showed that hypothyroidism in rats leads to early brain changes reminiscent of AD, notably hippocampal Ab and proinflammatory cytokine production, Tau phosphorylation associated with memory deficits; thyroid hormone (TH) supplementation rescues most of these alterations. These findings associate for the first time hypothyroidism and several AD-related pathological hallmarks. Today, we want to characterize the inflammatory response and determine its potential role in the sequence of events that leads to a favorable environment for the development of AD pathology under conditions of hypothyroidism. The rotation’s project will join this program.
Address: Département Cognition-Comportement - Neuroscience Paris-Saclay Institute NEUROPSI - Bâtiment 145, Centre d'études de Saclay 91191 Gif sur Yvette
Phone number: +33 (0)169154988 ; Email: Valerie.firstname.lastname@example.org