Deficit of synaptic plasticity in Alzheimer’s disease: role of astrocytes
Dates:January 2, 2018 - June 29, 2018
Application deadline:June 29, 2018
~ Jan-March 2018
~ April-June 2018
Learning and memory are crucial in the interaction of an individual with the environment and are fundamental brain processes that are affected in a large number of brain diseases including Alzheimer’s disease (AD). We hypothesize that, in addition to information processing by neurons, astrocytes play a fundamental role, yet under-estimated, in memory regulation and encoding. Our project aims to explore using cutting-edge methods (live calcium imaging in freely moving mice, WT and 3xTG) the contribution of astrocytes in memory formation by releasing gliotransmitters related to energy pathways.
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