Brain Rhythms and Neural Coding of Memory

Leader

Research center

11 place Marcelin Berthelot
75231 Paris
Serge Haroche

Institution

Collège de France
CNRS
Inserm
ED 158 - 474

Laboratory

Center for Interdisciplinary Research in Biology (CIRB)
UMR7241 - U1050
LabEx Memolife

Keywords

Neurophysiology
Neuromodulation
neural oscillation
decision
visual handicap
 

Publications

Maingret N, Girardeau G, Todorova R, Goutierre M1,2,3,4, Zugaro M. Hippocampo-cortical coupling mediates memory consolidation during sleep. Nat Neurosci. 2016 Jul;19(7):959-64. doi: 10.1038/nn.4304. Epub 2016 May 16.

Catanese J, Viggiano A, Cerasti E, Zugaro MB, Wiener SI. (2014) Retrospectively and prospectively modulated hippocampal place responses are differentially distributed along a common path in a continuous T-maze. J Neurosci. 34(39):13163-9

Cei A, Girardeau G, Drieu C, Kanbi KE, Zugaro M. Reversed theta sequences of hippocampal cell assemblies during backward travel. Nat Neurosci. 2014 May;17(5):719-24.

Girardeau G, Cei A, Zugaro M. Learning-induced plasticity regulates hippocampal sharp wave-ripple drive. J Neurosci. 2014 Apr 9;34(15):5176-83.

Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro M, Wiener SI (2013) Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. J. Neuroscience 33(42):16790-5.

Catanese J, Cerasti E, Zugaro M, Viggiano A, Wiener S.I.(2012) Dynamics of decision-related activity in prospective hippocampal place cells. Hippocampus 22(9):1901-11 

Fields of research

Neurophysiology / systems neuroscience

Research Theme

Our research targets the neurophysiological basis of spatial navigation and memory, in particular the network processes that integrate internal signals (representations, expectations, emotions) and multisensory information from the environment to store and update memories, and guide behavior. We record large neuronal ensembles and local field potential oscillations in freely moving animals performing learning and memory tasks. We focus on the hippocampal system (affected in epilepsy and Alzheimer's disease), where neurons code for the position and direction of the head in space. To understand how this activity is implicated in memorization and in informing ongoing behavior, we simultaneously record in downstream structures such as prefrontal cortex (affected in schizophrenia) and ventral striatum (affected in Parkinson's disease). This provides tractable experimental models for high-level cognitive representations at the level of single neurons and neural networks.

ENP Students

Ralitsa TODOROVA

Team members

Sidney WIENER
Susan SARA
Chantal MILLERET

Lab rotation

Neural Mechanisms of Hippocampo-Cortical Communication in Memory and Planning

Team leader: 

ZUGARO Michael

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

The goal of this project is to study the neural mechanisms of memory and planning, using high density electrophysiology in freely moving rodents, to characterize the activity of large neuronal populations in multiple brain areas during learning of a spatial memory task.We will focus on the hippocampus, where neurons code for the location of the animal in space and allow trajectory planning, and on prefrontal cortex, which is involved in working memory and planning. Our internet website:  http://zugarolab.net

Contact

Collège de France - CIRB - 11, place M. Berthelot 75005 Paris - +33 1 44 27 12 93 - michael.zugaro@college-de-france.fr

Supervisor: 

BENABDALLAH Nadia & ZUGARO Michaël