Brain Development Team

Leader

Research center

47 bld de l'Hôpital
75651 Paris
Alexis Brice

Institution

Inserm
CNRS
Université Pierre et Marie Curie
ED 3C - 158

Laboratory

UMRS 1127 UMR 7225
Allen Distinguished Investigator Award 2016

Keywords

Brain Development, Neuronal networks, Genetic regulation, Drosophila, Mouse
Available to host a PhD student

Publications

Hassan, B. A. and P. Robin Hiesinger. 2015. Beyond Molecular Codes: Simple Rules to Wire Complex Brains. Cell 163:285-91.

Okray, Z., C E.F. de Esch, H. Van Esch, K. Devriendt, A. Claeys, J. Yan, J. Verbeeck, G. Froyen, R. Willemsen, F. M.S. de Vrij, and B. A. Hassan. 2015. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol. Med. 7:423-37.

Langen M., M. Koch, J. Yan, N. De Geest, M-L Erfurth, B. D. Pfeiffer, D. Schmucker, Y. Moreau and B. A. Hassan. 2013. Mutual inhibition among neighboring postmitotic neurons regulates individuality and robustness of brain wiring. eLife 2:e00337.

Xiao-Jiang Quan, Liqun Yuan, Luca Tiberi, Annelies Claeys, Natalie De Geest, Jiekun Yan, Rob van der Kant, Wei R. Xie, Tiemo J. Klisch, Joost Shymkowitz, Frederic Rousseau, Mathieu Bollen, Monique Beullens, Huda Y. Zoghbi, Pierre Vanderhaeghen, Bassem A. Hassan. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

Fields of research

Neurogenetics / neurodevelopment

Research Theme

Our lab is interested in how a brain develops and how it is protected from disorders, like intellectual disability and neurodegeneration.Although the emphasis in the media and, even the scientific literature tends to be on brain disease, it is worth remembering that vastmajority of people - and indeed animals - are in fact healthy and do not suffer from brain disorders. In fact, brain health is so robustthat often even individuals with mutations that could lead to disease do not develop the symptoms. How does brain developmentresist dysregulation more than 95% of the time? How did the brain evolve to be so robust to ageing, toxic insults and even geneticmutations? To answer these questions, we study the normal process of brain formation as well as the genes that keep the brainhealthy for as long as possible. To do this, we use different models, such as the fruit fly, the mouse and neurons cultured in a dish.We examine how neurons are born in the brain, how they connect to each other and how they work together to drive behavior. Weexamine what happens to these different aspects as animals age, or when they are engineered to carry certain mutations. We areespecially interested in genes which when mutated make the development or ageing of the brain less robust.



Lab rotation

Molecular signature of neuronal de-differentiation

Team leader: 

HASSAN Bassem

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

The acquisition of the neuronal fate is a complex process in which there is a forward activation of neuronal characteristics, but also an active prevention of regression to previous and more naïve states. How neuronal fate memory is achieved is extremely important and relatively unknown. Using mutants that present neuronal de-differentiation we want to understand the key changes driving the loss of cell fate memory and how are they regulated. 

Contact

Institut du Cerveau et de la Moelle épinière - 47, boulevard de l’Hôpital 75013 Paris - +33 1 57 27 40 00 - Natalia.moragarcia@icm-institute.org

Supervisor: 

MORA GARCIA Natalia

Brain development

Team leader: 

HASSAN Bassem

Dates: 

January 2, 2018 - June 29, 2018

Application deadline: 

June 29, 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

Variation of the size of brain areas and of sensory organs underlies behavioral differences between species, and presumably between individuals within a species. Importantly, to maintain correct information processing, size variation must be coordinated between related brain regions or sensory organs and target brain regions. In this project, we will use Drosophila visual system as a model to investigate how such coordination is achieved during nervous system development. 

Key words: developmental variation, drosophila, visual system, brain development.

Contact

Institut du Cerveau et de la Moelle épinière - 47, boulevard de l'Hôpital 75013 Paris - +33 1 57 27 46 83 - ariane.ramaekers@icm-institute.org

Supervisor: 

RAMAEKERS Ariane