Neuropharmacology / cell signaling

Brain Development Team

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Brain Development, Neuronal networks, Genetic regulation, Drosophila, Mouse

ENP label: 

2017

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Our lab is interested in how a brain develops and how it is protected from disorders, like intellectual disability and neurodegeneration.Although the emphasis in the media and, even the scientific literature tends to be on brain disease, it is worth remembering that vastmajority of people - and indeed animals - are in fact healthy and do not suffer from brain disorders. In fact, brain health is so robustthat often even individuals with mutations that could lead to disease do not develop the symptoms. How does brain developmentresist dysregulation more than 95% of the time?

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

Doctoral School: 

ED 3C - 158
Laboratory

Initiatives d'Excellence: 

Allen Distinguished Investigator Award 2016
Publications

Publications: 

Hassan, B. A. and P. Robin Hiesinger. 2015. Beyond Molecular Codes: Simple Rules to Wire Complex Brains. Cell 163:285-91.

Okray, Z., C E.F. de Esch, H. Van Esch, K. Devriendt, A. Claeys, J. Yan, J. Verbeeck, G. Froyen, R. Willemsen, F. M.S. de Vrij, and B. A. Hassan. 2015. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol. Med. 7:423-37.

Langen M., M. Koch, J. Yan, N. De Geest, M-L Erfurth, B. D. Pfeiffer, D. Schmucker, Y. Moreau and B. A. Hassan. 2013. Mutual inhibition among neighboring postmitotic neurons regulates individuality and robustness of brain wiring. eLife 2:e00337.

Xiao-Jiang Quan, Liqun Yuan, Luca Tiberi, Annelies Claeys, Natalie De Geest, Jiekun Yan, Rob van der Kant, Wei R. Xie, Tiemo J. Klisch, Joost Shymkowitz, Frederic Rousseau, Mathieu Bollen, Monique Beullens, Huda Y. Zoghbi, Pierre Vanderhaeghen, Bassem A. Hassan. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

Genes Circuits Rhythms and Neuropathology

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Parkinson’s disease
dopamine
Neurodegeneration
Locomotor aging
Drosophila models

ENP label: 

2016

Research Center / Institute: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Research Unit Code: 

UMR 8249

Our research program aims at understanding how the brain controls locomotor activity, and how aging or neurodegenerative pathologies, such as Parkinson’s disease and amyotrophic lateral sclerosis, alter this function and in general brain functioning. We try to identify neuronal networks controlling locomotor activity and circadian mechanisms that modulate them in health and disease. Our approach combines genetics methods, brain imaging and behavioral assays.

Leader

Leader: 

Personal

Team members: 

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

ESPCI

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 158 3C
Laboratory

Surname: 

Laboratoire Plasticité du cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL
Publications

Publications: 

Cassar M.#, Issa A.-R.#, Riemensperger T.#, Petitgas C.#, Rival T.#, Coulom H.#, Iché-Torres M.#, Han K.-A. & Birman S#. (2015)A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T.#, Birman S.#, Stensmyr M. C. & Hansson B. S. (2014) Dopamine drivesDrosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T.#, Issa A.-R.#, Pech U., Coulom H.#, Nguy?n M.-V.#, Cassar M.#, Jacquet M.#, Fiala A. & Birman S#. (2013) Asingle dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Pech U., Pooryasin A., Birman S#. & Fiala A. (2013) Visualization of the connections between Kenyon cells and aminergic neuronsin the Drosophila melanogaster brain using split-GFP reconstitution. J. Comp. Neurol. 521(17):3992-4026

Reinhardt A., Feuillette S., Cassar M.#, Callens C.#, Thomassin H., Birman S.#, Lecourtois M., Antoniewski C. & Tricoire H. (2012)Lack of miRNA misregulation at early pathological stages in Drosophila neurodegenerative disease models. Front. Genet. 3:226

Cellular messenger codes for axon guidance

Main field of research: 

Neurogenetics / neurodevelopment

ENP label: 

2016

Research Center / Institute: 

Institut de la Vision

Research Unit Code: 

UMRS968 UMR7210 UM80

The mature nervous system is an intricate network in which neurons are connected to specific partners. The choice of these partners is crucial for the correct behavior of the network (meaning the nervous system) and is determined at early stages of development. Abnormal development of neuronal connections is responsible for a large range of neuronal pathologies, some of them affecting vision. Research carried on by our team focuses on a better understanding of the development of sensory maps including the connection between the retina and the brain.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Pierre et Marie Curie
Inserm

University: 

UPMC

Doctoral School: 

ED3C
Laboratory

Initiatives d'Excellence: 

Labex Lifesenses
Publications

Publications: 

Averaimo S*, Assali A*, Couvet S, Zagar Y, Ioana Genescu I, Rebsam A, Nicol X. Local cAMP signaling restricted to lipid rafts isrequired for the developmental refinement of axonal arbors. In preparation. Under review, Nature Communications

Averaimo S, Nicol X. Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front CellNeurosci. 2014 Nov 13.

Nicol X, Hong KP, Spitzer NC. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A.2011 Aug 16;108(33):13776-81.

Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P. cAMP oscillations and retinal activity arepermissive for ephrin signaling during the establishment of the retinotopic map. Nat Neurosci. 2007 Mar;10(3):340-7.

Nicol X, Muzerelle A, Rio JP, Métin C, Gaspar P. Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction ofexuberant retinal axons. J Neurosci. 2006 Jan 18;26(3):862-72.

Pathophysiology and Therapeutic Targets of the Blood-Brain Barrier

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

brain interfaces, psychotropic drugs, psychiatric disorders, transporters, biomarkers

ENP label: 

2015

Research Center / Institute: 

UMR-S 1144 Therapeutic Optimisation in Neuropsychopharmacology

Research Unit Code: 

UMRS1144

Our team "Pathophysiology and therapeutic targets of the blood-brain barrier" was created in 2014 with a membership of Inserm inthe new five-year plan. It comes from the team of the former Inserm U705 (ex Director Prof. JM Scherrmann) which studied for morethan 20 years mechanisms of drug exchange in brain barriers. actually, we study the variability factors of two essential functions ofthe BBB, the maintenance of brain homeostasis towards endogenous compounds and the control of brain exposure to drugs and toxicsubstances.

Leader

Leader: 

Personal

Team members: 

Fanchon BOURASSET
Stéphanie CHASSEIGNEAUX
Salvatore CISTERNINO
Benoit HOSTEN
Aude JACOB
Marie-Claude MENET
Nathalie RIZZO
Bruno SAUBAMEA
Jean-Michel SCHERRMANN
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris Descartes
Université Paris Diderot

Doctoral School: 

MTCI 563
Laboratory

Surname: 

Variabilité de réponses aux psychotropes
Publications

Publications: 

Jacob A, Hartz AM, Potin S, Coumoul X, Yousif S, Scherrmann JM, Bauer B, Declèves X. (2011) Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. Fluids Barriers CNS. Aug 25;8:23.

Ball K, Bouzom F, Scherrmann JM, Walther B, Declèves X. (2012) Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodone. J Pharm Sci. 101:4277-92

Yousif S, Chaves C, Potin S, Scherrmann JM, Declèves X. (2012) Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation. J Neurochem. 123:491-503

Mérian J, Boisgard R, Decleves X, Thezé B, Texier I, Tavitian B. Synthetic lipid nanoparticles targeting steroid organs. J Nucl Med. 2013 Nov;54(11):1996-2003.

Ball K, Bouzom F, Scherrmann JM, Walther B, Declèves X. A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development. Mol Pharm. 2014 Jan 29.

Lloret-Linares C, Luo H, Rouquette A, Labat L, Poitou C, Tordjman J, Bouillot JL, Mouly S, Scherrmann JM, Bergmann JF, Declèves X. The effect of morbid obesity on morphine glucuronidation.Pharmacol Res. 2016 Sep 5. pii: S1043-6618(16)30855-6. doi: 10.1016/j.phrs.2016.08.031.

Biomarkers of relapse and therapeutic response in addictions and mood disorders

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

addiction
Mood disorders
Neuropsychophamarcology
Genomics
Biomarkers

ENP label: 

2015

Research Center / Institute: 

UMR-S 1144 Therapeutic Optimisation in Neuropsychopharmacology

Research Unit Code: 

UMRS 1144

The "Biomarkers of relapse and therapeutic response in addictions and mood disorders" team develops research on mood disordersand addiction both at the clinical and fundamental level (ranked A, AERES 2013, creation 01/01/2014).The objective is to identifyclinical, biological, genetic or imaging-based markers of the response to psychotropic drugs (in the context of drug abuse or during thetreatment for mood disorders or pain management). These markers will allow us to better predict the response (therapeutic and sideeffects) in order to improve the therapeutic monitoring of patients.

Leader

Leader: 

Personal

Team members: 

Marie-Claire CYNTHIA
Jean-Louis LAPLANCHE
Jean-Pierre LEPINE
Emmanuel CURIS
Florence VORSPAN
Vanessa BLOCH
Frank QUESTEL
Sarah SPORTICHE
Gaël DUPUY
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris Descartes
Université Paris Diderot

Doctoral School: 

ED 436
Laboratory

Surname: 

Variabilité de réponses aux psychotropes
Publications

Publications: 

Geoffroy PA# , Scott J, Boudebesse C, Lajnef M, Henry C, Leboyer M, Bellivier F# , Etain B. Sleep in patients with remitted bipolar disorders: a meta-analysis of actigraphy studies. Acta Psychiatr Scand. 2014 28.

Bellivier F#, Geoffroy PA#, Etain B, Scott J. Sleep- and circadian rhythm-associated pathways as therapeutic targets in bipolar disorder. Expert Opin Ther Targets. 2015 Mar 2:1-17.

Boudebesse C, Geoffroy PA# , Henry C, Germain A, Scott J, Lajnef M, Leboyer M, Bellivier F# , Etain B. Eur Psychiatry. 2014 4.

Mouly S, Bloch V, Peoc'h K, Houze P, Labat L, Ksouda K, Simoneau G, Declèves X, Bergmann JF, Scherrmann JM, Laplanche JL#, Lepine JP#, Vorspan F#. Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity. Br J Clin Pharmacol. in press

Geoffroy PA# , Boudebesse C, Henrion A, Jamain S, Henry C, Leboyer M, Bellivier F# , Etain B. An ASMT variant associated with bipolar disorder influences sleep and circadian rhythms: a pilot study. Genes Brain Behav. 2014 13(3):299-304.

Development and Evolution of the Forebrain (DECA)

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Development, Evolution, Behavior, Adaptation, Evolutionary forces

ENP label: 

2015

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

We address two questions:

1) Which mechanisms underly the evolution and the diversification of the vertebrate forebrain?

2) What are the evolutionary forces involved?

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud

University: 

Université Paris Sud

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Département Développement-Évolution

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

Hinaux H, Devos L, Blin M, Elipot Y, Bibliowicz J, Alié A, Rétaux S. Sensory evolution in blind cavefish is driven by early embryonic events during gastrulation and neurulation. Development. 2016 Dec 1;143(23):4521-4532. 

Yannick Elipot, Hélène Hinaux, Jacques Callebert, Jean-Marie Launay, Maryline Blin and Sylvie Rétaux (2014) A Mutation in theEnzyme Mono Amine Oxidase explains part of the Astyanax Cavefish Behavioural Syndrome. Nature Communications, 5:3647. IF10.

Yannick Elipot, Laurent Legendre, Stéphane Père, Frédéric Sohm and Sylvie Rétaux (2014) Astyanax transgenesis and husbandry:how cavefish enters the lab. Zebrafish, 11(4):291-9. IF3 (with cover picture)

Luis Espinasa, Jonathan Bibliowicz, William R. Jeffery, and Sylvie Rétaux. (2014) Enhanced prey capture skills in Astyanax cavefishlarvae are independent from eye loss. Evo Devo 5: 35.

Suzanne E. McGaugh, Joshua B. Gross, Bronwen Aken, Maryline Blin, Richard Borowsky, Domitille Chalopin, Hélène Hinaux, WilliamJeffery, Alex Keene, Li Ma, Pat Minx, Daniel Murphy, Kelly E. O’Quin, Sylvie Rétaux, Nicolas Rohner, Steve M. J. Searle, BethanyStahl, Cliff Tabin, Jean-Nicolas Volff, Masato Yoshizawa, Wes C. Warren. (2014) The cavefish genome reveals candidate genes foreye loss. Nature Communications, Oct 20; 5:5307.

Hélène Hinaux, Maryline Blin, Julien Fumey, Laurent Legendre, Didier Casane and Sylvie Rétaux (2014) Lens defects in Astyanaxmexicanus cavefish: focus on crystallin evolution and function. Developmental Neurobiology, 28. [Epub ahead of print].

Dynamics of Neuronal Structure in Health and Disease

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

imaging
in vitro
Cannabinoids
remodeling in vivo

ENP label: 

2015

Research Center / Institute: 

Institut de Psychiatrie et Neurosciences de Paris, IPNP (ex-CPN) - Centre Hospitalier Sainte Anne

Research Unit Code: 

UMRS 894

Research in my team is focused on neuronal G-protein Coupled Receptors (GPCRs). These sensory proteins are important targets oftherapeutic and abused drugs, and are usually studied by pharmacology or electrophysiology, but we assume that their functioncannot be fully understood without considering their sub-cellular environment. We have indeed found unexpectedly close relationshipbetween neuropharmacology and neuronal cell biology.

Leader

Leader: 

Personal

Team members: 

Sophie Pezet
Diana Zala
Institutions

Doctoral School: 

ED3C
Laboratory

Initiatives d'Excellence: 

LabEx MemoLife
Publications

Publications: 

Roland BA#, Ricobaraza A#, Carrel D#, Jordan MB, Rico F, Simon A#, Humbert-Claude M#, Ferrier J#, McFadden HM#, Scheuring S, Lenkei Z#. Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth, eLife, 2014, Sep 15;3. doi:10.7554/eLife.03159

Osmanski B, Pezet S#, Ricobaraza A#, Lenkei Z#*, Tanter M*. fUltrasound Imaging of Intrinsic Connectivity in the Living Rat Brain with High Spatiotemporal Resolution, Nature Communications, 2014, 2014 5:5023. *: co-senior authors

Thibault K#, Lin WK, Rancillac A, Fan M, Snollaerts T, Sordoillet V, Hamon M, Smith GM, Lenkei Z#, Sophie P#. BDNF-Dependent Plasticity Induced by Peripheral Inflammation in the Primary Sensory and the Cingulate Cortex Triggers Cold Allodynia and Reveals a Major Role for Endogenous BDNF As a Tuner of the Affective Aspect of Pain. J. Neurosci, 29 October 2014, 34(44):14739-14751

Ladarre D#, Roland BA#, Biedzinski S, Ricobaraza A#, Lenkei Z#. Polarized cellular patterns of endocannabinoid production and detection shape cannabinoid signaling in neurons. Frontiers in Cellular Neuroscience, 2014 (in press)

Simon AC#, Loverdo C, Gaffuri AL#, Urbanski M, Ladarre D#, Carrel D, Rivals I, Leterrier C#, Benichou O, Dournaud P, Szabo B, Voituriez R, Lenkei Z#. Activation-dependent plasticity of polarized GPCR distribution on the neuronal surface. J Mol Cell Biol. 2013 Aug;5(4):250-65.

Development of the Spinal Cord Organization DSCO

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Développement
synaptogénèse
Moelle épinière
Activité neuronale précoce
Glie

ENP label: 

2014

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

U1130 UMR8246 UMCR18

L’objectif général de notre équipe de recherche est de mieux comprendre les mécanismes impliqués dans l’émergence des premiers réseaux synaptiques au cours du développement du système nerveux cetral, en utilisant la moelle épinière embryonnaire comme modèle principal. Nous nous intéressons notamment aux mécanismes sous-tendant l’activité neuronale précoce et au rôle de cette activité dans la synaptogenèse et la mise en place de premiers réseaux synaptiques fonctionnels. Notre équipe s’intéresse également au rôle des interactions entre neurones et cellules gliales dans ces mêmes processus.

Leader

Leader: 

Co leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Neuroscience Paris Seine
Publications

Publications: 

Czarnecki A, Le Corronc H, Rigato C, Le Bras B, Couraud F, Scain AL, Allain AE, Mouffle C, Bullier E, Mangin JM, Branchereau P, Legendre P. Acetylcholine controls GABA-, glutamate-, and glycine-dependent giant depolarizing potentials that govern spontaneous motoneuron activity at the onset of synaptogenesis in the mouse embryonic spinal cord. J Neurosci. 2014 Apr 30;34(18):6389-404. doi: 10.1523/JNEUROSCI.2664-13.2014.

SWINNEN N, SMOLDERS S, AVILA A, NOTELAERS K, PAESEN R, AMELOOT M, BRONE B, # LEGENDRE P, RIGO JM (2013) Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo. Glia. 2013 Feb;61(2):150-63

# LE BRAS B, # FREAL A, # CZARNECHI A, # LEGENDRE P, # BULLIER E, KOMADA M, BROPHY PJ, # DAVENNE M, # COURAUD F (2013) In vivo assembly of the axon initial segment in motor neurons. Brain Struct Funct. 2013 Jun 2. [Epub ahead of print]

# RIGATO C, SWINNEN N, BUCKINX R, COUILLIN I, # MANGIN JM, RIGO JM, # LEGENDRE P, # LE-CORRONC H. P2X7 receptors do not need coupling to pannexin-1 to control microglia proliferation in the spinal cord of mouse embryos. J Neurosci. 2012 Aug 22;32(34):11559-73.

# MANGIN JM, LI P, SCAFIDI J, GALLO V (2012) Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat Neurosci. 2012 Sep;15(9):1192-4

# CZARNECKI A, TSCHERTER A, STREIT J (2012) Network activity and spike discharge oscillations in cortical slice cultures from neonatal rat. Eur J Neurosci. 2012 Feb;35(3):375-88

CELLULAR MECHANISMS OF NEUROTRANSMISSION

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Depression
schizophrenia
psychiatry

ENP label: 

2014

Research Unit Code: 

UMR 894

Le projet de l'équipe est d’identifier de nouvelles protéines et de nouveaux mécanismes impliqués dans le trafic neuronal de récepteurs, dans le but de caractériser de nouvelles cibles thérapeutiques dans le domaine de la dépression, la schizophrénie et d’autres pathologies neuronales et psychiatriques.

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Paris Descartes

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Publications

Publications: 

Al Awabdh Sana , ? Masson J., Hamon M., Emerit M.B., Darmon M. J Neurosci. 2012 32(41):14227-14241.

Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24

M. Humbert-Claude, E. Davenas, F. Gbahou, L. Vincent and J. M. Arrang: Psychopharmacology (Berl). 2012;220(1):225-41.

F. Gbahou, A. Rouleau and J. M. Arrang: Br J Pharmacol. 2012 166(6):1860-71.

M. El Hage, J. Masson, A. Conjard-Duplany, B. Ferrier, G. Baverel and G. Martin: J Cereb Blood Flow Metab. 2012.

Gene Regulation and Adaptive Behaviors

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

behavior
Epigenetics
Stress response
Molecular genetics
Glucocorticoid Receptor

ENP label: 

2014

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

U1130 UMR8246 UMCR18

To decipher the molecular mechanisms that allow brain gene expression to adapt to environmental challenges, we focus on the function of inducible transcription factors. Glucocorticoid hormones (GC) plays a key role in physiological and psychological responses to stress. It has multifaceted functions in the brain, most likely reflecting distinct actions in different brain areas and cell  populations.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie
Laboratory

Surname: 

Neuroscience Paris Seine
Publications

Publications: 

#Barik J, Marti F, Morel C, Fernandez SP, #Lanteri C, #Godeheu G, #Tassin JP, Mombereau C, Faure P, #Tronche F. Chronic stress triggers social aversion via GR in dopaminoceptive neurons. Science, 2013 339(6117):332-5

#Carrillo MA, #Pasco M, Arnoux I, #Maatouk L, Sanz Diez A, Delahaye M, Herrero MT, Newman TA, Calvo CF, Audinat E, #Tronche F, #Vyas S. Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation. Cell Death & Differentiation, 2013 20(11):1546-1557.

Revest JM, Le Roux A, Roullot-Lacarriere V, Kaouane N, Vallee M, Kasanetz F, Rouge-Pont F, #Tronche F, Desmedt A and Piazza PV. BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Molecular Psychiatry, 2013, doi: 10.1038, in press

Valtat B, Riveline JP, Zhang P, Singh A, Armanet M, Venteclef N, Besseiche A, Kelly D, #Tronche F, Ferré P, Gautier JF, Bréant B, Blondeau B. Fetal PGC-1? Overexpression Programs Adult Pancreatic ?-cell Dysfunction. Diabetes. 2013 62:1206-16

Romanò N, Yip SH, Hodson DJ, Guillou A, #Parnaudeau S, #Tronche F, Bonnefont X, Bunn SJ, Grattan DR, Mollard P, Martin AO. Electrical robustness during phenotypic plasticity of hypothalamic dopaminergic neurons. J Neuroscience, 33(10):4424-4433.