Neurogenetics / neurodevelopment

Mice, Molecules and Synapse formation

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Synapses, molecules, transgenesis, mice, development

ENP label: 

2007

Research Center / Institute: 

Collège de France

Research Unit Code: 

UMR 7241 - U1050

Le cerveau est composé de nombreux types de neurones communiquant entre eux via descontacts spécifiques, les synapses. Chaque neurone peut être contacté par plusieurs typesde neurones et à son tour peut envoyer des connections sur différentes autres populationsneuronales : la structure de ces réseaux peut être comparée à celle des réseauxélectriques. Comment la formation de ces réseaux précis est contrôlée reste encore malcompris. Toute perturbation de leur formation peut entraîner des maladies neurodévelopmentales du type autisme.

Leader

Leader: 

Personal

ENP Students: 

Institutions

Principal Institution: 

Collège de France

Affiliated institutions: 

CNRS
Inserm

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

Center for Interdisciplinary Research in Biology

Initiatives d'Excellence: 

Labex Memolife Idex PSL* ERC Consolidator Grant 2016
Publications

Publications: 

 

Usardi A, Iyer K, Sigoillot SM, Dusonchet A, Selimi F. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Dev Neurobiol. 2017 Jan;77(1):75-92. doi: 10.1002/dneu.22412. Epub 2016 Jul 8. PubMed PMID: 27328461.

Sigoillot SM, Iyer K, Binda F, González-Calvo I, Talleur M, Vodjdani G, Isope P, Selimi F. The Secreted Protein C1QL1 and Its Receptor BAI3 Control the Synaptic Connectivity of Excitatory Inputs Converging on Cerebellar Purkinje Cells. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00059-5. doi: 10.1016/j.celrep.2015.01.034. [Epub ahead of print] PubMed PMID: 25660030.

Proville RD, Spolidoro M, Guyon N, Dugué GP, Selimi F, Isope P, Popa D, Léna C. Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements. Nat Neurosci. 2014 Sep;17(9):1233-9. doi: 10.1038/nn.3773. Epub 2014 Jul 27. PubMed PMID: 25064850.

Chaumont J, Guyon N, Valera AM, Dugué GP, Popa D, Marcaggi P, Gautheron V, Reibel-Foisset S, Dieudonné S, Stephan A, Barrot M, Cassel JC, Dupont JL, Doussau F, Poulain B, Selimi F, Léna C, Isope P. Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16223-8. doi: 10.1073/pnas.1302310110. Epub 2013 Sep 17. PubMed PMID: 24046366; PubMed Central PMCID: PMC3791757.

Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Mol Psychiatry. 2013 Aug;18(8):943-50. doi: 10.1038/mp.2013.46. Epub 2013 Apr 30. PubMed PMID: 23628982; PubMed Central PMCID: PMC3730300.

 

Brain Development Team

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Brain Development, Neuronal networks, Genetic regulation, Drosophila, Mouse

ENP label: 

2017

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Our lab is interested in how a brain develops and how it is protected from disorders, like intellectual disability and neurodegeneration.Although the emphasis in the media and, even the scientific literature tends to be on brain disease, it is worth remembering that vastmajority of people - and indeed animals - are in fact healthy and do not suffer from brain disorders. In fact, brain health is so robustthat often even individuals with mutations that could lead to disease do not develop the symptoms. How does brain developmentresist dysregulation more than 95% of the time?

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

Doctoral School: 

ED 3C - 158
Laboratory

Initiatives d'Excellence: 

Allen Distinguished Investigator Award 2016
Publications

Publications: 

Hassan, B. A. and P. Robin Hiesinger. 2015. Beyond Molecular Codes: Simple Rules to Wire Complex Brains. Cell 163:285-91.

Okray, Z., C E.F. de Esch, H. Van Esch, K. Devriendt, A. Claeys, J. Yan, J. Verbeeck, G. Froyen, R. Willemsen, F. M.S. de Vrij, and B. A. Hassan. 2015. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol. Med. 7:423-37.

Langen M., M. Koch, J. Yan, N. De Geest, M-L Erfurth, B. D. Pfeiffer, D. Schmucker, Y. Moreau and B. A. Hassan. 2013. Mutual inhibition among neighboring postmitotic neurons regulates individuality and robustness of brain wiring. eLife 2:e00337.

Xiao-Jiang Quan, Liqun Yuan, Luca Tiberi, Annelies Claeys, Natalie De Geest, Jiekun Yan, Rob van der Kant, Wei R. Xie, Tiemo J. Klisch, Joost Shymkowitz, Frederic Rousseau, Mathieu Bollen, Monique Beullens, Huda Y. Zoghbi, Pierre Vanderhaeghen, Bassem A. Hassan. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

ALS causes and mechanisms of motor neuron degeneration

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Amyotrophic Lateral Sclerosis (ALS)
genetics
motor neurons degeneration
neuroimmunology
iPSc

ENP label: 

2016

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Our second aim is to assess the crucial question whether different ALS genes lead to motor neuron death and deleteriousmicroglia/macrophage responses by gain or loss of function mechanisms. A major focus will be on newly discovered and theremaining unknown ALS genes with approaches including novel mouse modeling and gene discovery.Our project relies on the combined capacities of 4 PIs and 2 supporting clinicians forming this ALS team.

Leader

Leader: 

Institutions

Doctoral School: 

ED 158 3C
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, Labex revive
Publications

Publications: 

Phenotype difference between ALS patients with expanded repeats in C9ORF72 and patients with mutations in other ALS-related genes. Millecamps S, Boillée S, Le Ber I, Seilhean D, Teyssou E, Giraudeau M, Moigneu C, Vandenberghe N, Danel-Brunaud V, Corcia P, Pradat PF, Le Forestier N, Lacomblez L, Bruneteau G, Camu W, Brice A, Cazeneuve C, Leguern E, Meininger V, Salachas F. J Med Genet. 2012 Apr;49(4):258-63.

Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis. Teyssou E, Chartier L, Amador MD, Lam R, Lautrette G, Nicol M, Machat S, Da Barroca S, Moigneu C, Mairey M, Larmonier T, Saker S, Dussert C, Forlani S, Fontaine B, Seilhean D, Bohl D, Boillée S, Meininger V, Couratier P, Salachas F, Stevanin G, Millecamps S. Neurobiol Aging. 2017 Oct;58:239.e11-239.e20

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S. Brain. 2015 Jan;138(Pt 1):53-68.

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92.

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Lelli A, Gervais A, Colin C, Chéret C, Ruiz de Almodovar C, Carmeliet P, Krause KH, Boillée S, Mallat M. Glia. 2013 Sep;61(9):1542-55.

 

Central COntrol oF Feeding behaviour and Energy Expenditure (C2OFFEE)

Main field of research: 

Neurophysiology / systems neuroscience

ENP label: 

2016

Research Center / Institute: 

Unité de Biologie Fonctionnelle et Adaptative BFA

Research Unit Code: 

UMR 8251

The modern abundance of energy-rich foods combined with a shift to more sedentary lifestyles has led to a thermodynamic imbalance, and consequently, excessive caloric intake and reduced energy expenditure are the main causes for the prevalence of obesity. According to the World Health Organization (WHO) the obesity worldwide obesity has more than doubled since 1980. In 2008, 1.5 billion adults, 20 and older, were overweight.

Leader

Leader: 

Personal

Team members: 

Julien Castel
Raphaël Denis
Claire Martin
Mar Quiñones Téllez
Anne-Sophie Delbes
Chloé Berland
Olja Kacanski
Institutions

Principal Institution: 

Université Paris Diderot

Affiliated institutions: 

CNRS

University: 

Université Paris Diderot

Doctoral School: 

ED157
Laboratory

Initiatives d'Excellence: 

USPC, collaborative ANR 2016
Publications

Publications: 

Garcia-Caceres, C., Quarta, C., Gao, Y., Varela, L., Gruber T, Legutko, B., Jastroch M., Johansson, P., Ninkovic J, Yi, CX., Le Thuc O, Meyer, C., Pfluger, PT., Fernandez AM., Luquet, S., Woods SC., Torres-Alemán, I., Kahn, C.R., Götz, M., Horvath, TL. & Tschöp, MH*. (2016) Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell 166, 867-880. (IF 2015:32.857)

 Denis, RG., Joly, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S., Cansell, C., Dehouck, B., Castel, J., Delbes, AS., Martinez, S.,Lacombe, A., Rouch, C., Kassis, N., Fehrentz,J-A., Martinez, J, Verdié, P., Hnasko, T, Palmiter, RD., Krashes, MJ., Güler, A., Magnan, C., Luquet, S (2015). Palatability can drive feeding independent of AgRP neurons. Cell Metab 22, 646-657. (IF 2015 :17.897)

Sun, X., Luquet, S., Small, DM. (2017). DRD2: Bridging the genome and ingestive behavior. Trends in Cognitive Sciences. Trends Cogn Sci 21, 372-384.. (IF 2015:17.85)

 Geurts, L., Everard, A., Van Hul, M., Essaghir, A., Duparc, T., Matamoros, S., Plovier, H., Castel, J., Denis, R.G., Bergiers, M., Druart, C., Alhouayek, M., Delzenne, N.M., Muccioli, G.G., Demoulin, J.B., Luquet, S., and Cani, P.D. (2015). Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. Nature communications 6, 6495 (IF2015: 12.00)

Cansell, C., Castel, J., Denis, R., Rouch, C., Delbes, AS., Martinez, S., Mestivier, D., Finan, B., Maldonado-Aviles, J.G, Rijnsburger, M.,  Tschöp, M.H., DiLeone, R.J., Eckel, R.H., La Fleur, S., Magnan, C., Hnasko, T., Luquet., S (2014). Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry 19, 1095-1105. (IF2015: 13.314)

Genes Circuits Rhythms and Neuropathology

Main field of research: 

Neuropharmacology / cell signaling

Keywords: 

Parkinson’s disease
dopamine
Neurodegeneration
Locomotor aging
Drosophila models

ENP label: 

2016

Research Center / Institute: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Research Unit Code: 

UMR 8249

Our research program aims at understanding how the brain controls locomotor activity, and how aging or neurodegenerative pathologies, such as Parkinson’s disease and amyotrophic lateral sclerosis, alter this function and in general brain functioning. We try to identify neuronal networks controlling locomotor activity and circadian mechanisms that modulate them in health and disease. Our approach combines genetics methods, brain imaging and behavioral assays.

Leader

Leader: 

Personal

Team members: 

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

ESPCI

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 158 3C
Laboratory

Surname: 

Laboratoire Plasticité du cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL
Publications

Publications: 

Cassar M.#, Issa A.-R.#, Riemensperger T.#, Petitgas C.#, Rival T.#, Coulom H.#, Iché-Torres M.#, Han K.-A. & Birman S#. (2015)A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T.#, Birman S.#, Stensmyr M. C. & Hansson B. S. (2014) Dopamine drivesDrosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T.#, Issa A.-R.#, Pech U., Coulom H.#, Nguy?n M.-V.#, Cassar M.#, Jacquet M.#, Fiala A. & Birman S#. (2013) Asingle dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Pech U., Pooryasin A., Birman S#. & Fiala A. (2013) Visualization of the connections between Kenyon cells and aminergic neuronsin the Drosophila melanogaster brain using split-GFP reconstitution. J. Comp. Neurol. 521(17):3992-4026

Reinhardt A., Feuillette S., Cassar M.#, Callens C.#, Thomassin H., Birman S.#, Lecourtois M., Antoniewski C. & Tricoire H. (2012)Lack of miRNA misregulation at early pathological stages in Drosophila neurodegenerative disease models. Front. Genet. 3:226

Cellular messenger codes for axon guidance

Main field of research: 

Neurogenetics / neurodevelopment

ENP label: 

2016

Research Center / Institute: 

Institut de la Vision

Research Unit Code: 

UMRS968 UMR7210 UM80

The mature nervous system is an intricate network in which neurons are connected to specific partners. The choice of these partners is crucial for the correct behavior of the network (meaning the nervous system) and is determined at early stages of development. Abnormal development of neuronal connections is responsible for a large range of neuronal pathologies, some of them affecting vision. Research carried on by our team focuses on a better understanding of the development of sensory maps including the connection between the retina and the brain.

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Pierre et Marie Curie
Inserm

University: 

UPMC

Doctoral School: 

ED3C
Laboratory

Initiatives d'Excellence: 

Labex Lifesenses
Publications

Publications: 

Averaimo S*, Assali A*, Couvet S, Zagar Y, Ioana Genescu I, Rebsam A, Nicol X. Local cAMP signaling restricted to lipid rafts isrequired for the developmental refinement of axonal arbors. In preparation. Under review, Nature Communications

Averaimo S, Nicol X. Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front CellNeurosci. 2014 Nov 13.

Nicol X, Hong KP, Spitzer NC. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A.2011 Aug 16;108(33):13776-81.

Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P. cAMP oscillations and retinal activity arepermissive for ephrin signaling during the establishment of the retinotopic map. Nat Neurosci. 2007 Mar;10(3):340-7.

Nicol X, Muzerelle A, Rio JP, Métin C, Gaspar P. Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction ofexuberant retinal axons. J Neurosci. 2006 Jan 18;26(3):862-72.

Neurodevelopmental disorders

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

autism
speech & language
genes & cognition
social brain

ENP label: 

2016

Research Center / Institute: 

IFM - Institut du Fer à Moulin

Research Unit Code: 

UMR 839

We study neurodevelopmental disorders with the ultimate aim to identify key molecular and cellular mechanisms involved in establishing neuronal circuits underlying social cognition and behavior. We currently focus on the study of transcription factors whose mutations lead to speech and language disorder and to microcephaly and intellectual disability.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

UPMC

University: 

UPMC

Doctoral School: 

ED158 3C
Publications

Publications: 

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR. Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. J Neurosci. 2015 Aug 5;35(31):10911-26.

 

Schreiweis C, Bornschein U, Burguière E, Kerimoglu C, Schreiter S, Dannemann M, Goyal S, Rea E, French CA, Puliyadi R, Groszer M, Fisher SE, Mundry R, Winter C, Hevers W, Pääbo S, Enard W, Graybiel AM. Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14253-8.

Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M. MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis. Cell Rep. 2014 Jun 26;7(6):1779-88.

Aprea J, Prenninger S, Dori M, Ghosh T, Monasor LS, Wessendorf E, Zocher S, Massalini S, Alexopoulou D, Lesche M, Dahl A, Groszer M, Hiller M, Calegari F. Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment. EMBO J. 2013 Dec 11;32(24):3145-60.

French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM. An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Mol Psychiatry. 2012 Nov;17(11):1077-85.

 

Regulation of microtubule dynamics and functions

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Neurodegeneration
tubulin code
microtubule cytoskeleton
posttranslational modifications
neuronal differentiation

ENP label: 

2015

Research Center / Institute: 

Institut Curie - Centre de Recherche - Paris/Orsay

Research Unit Code: 

UMR3348

Microtubules are key cytoskeletal elements involved in a large number of functions in eukaryotic cells. They assemble from a protein dimer of a- and b-tubulin, two highly similar and conserved proteins. Tubulins are subject to a large variety of posttranslational modifications, which provide a rapid and reversible mechanism to diversify microtubule functions in cells. Our team is studying the mechanisms and functional roles of these modifications by using an interdisciplinary approach.

Leader

Leader: 

Personal

Team members: 

Annemarie Wehenkel
Cecilia Serieyssol
Kathiresan Natarajan
Laurence Vaslin
Maria Magiera
Ngoc-Lan Julie Nguyen
Sudarshan Gadadhar
Tiziana Giordano
Lurlene Akendengue
Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Institut Curie
Université Paris Sud 11

University: 

Université Paris Saclay / Université Paris Descartes

Doctoral School: 

SDSV / FdV
Laboratory

Initiatives d'Excellence: 

Labex CelTisPhyBio, contrat ANR, équipe FRM
Publications

Publications: 

Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, Bieche I, Rusconi F, Janke C (2017) Tubulin glycylation controls primary cilia length. J Cell Biol 216: 2701-2713

Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H (2015) Microtubule detyrosination guides chromosomes during mitosis. Science 348: 799-803

Nirschl JJ, Magiera MM, Lazarus JE, Janke C, Holzbaur ELF (2016) alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep: celrep 2509

Belvindrah R, Natarajan K, Shabajee P, Bruel-Jungerman E, Bernard J, Goutierre M, Moutkine I, Jaglin XH, Savariradjane M, Irinopoulou T, Poncer J-C, Janke C, Francis F (2017) Mutation of the alpha-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration. J Cell Biol 216: 2443-2461

Bosch Grau M, Masson C, Gadadhar S, Rocha C, Tort O, Marques Sousa P, Vacher S, Bieche I, Janke C (2017) Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. J Cell Sci 130: 938-949

 

Development and Evolution of the Forebrain (DECA)

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Development, Evolution, Behavior, Adaptation, Evolutionary forces

ENP label: 

2015

Research Center / Institute: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Research Unit Code: 

UMR9197

We address two questions:

1) Which mechanisms underly the evolution and the diversification of the vertebrate forebrain?

2) What are the evolutionary forces involved?

Leader

Leader: 

Institutions

Principal Institution: 

CNRS

Affiliated institutions: 

Université Paris Sud

University: 

Université Paris Sud

Doctoral School: 

ED 568 BioSigNe
Laboratory

Surname: 

Département Développement-Évolution

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

Publications: 

Hinaux H, Devos L, Blin M, Elipot Y, Bibliowicz J, Alié A, Rétaux S. Sensory evolution in blind cavefish is driven by early embryonic events during gastrulation and neurulation. Development. 2016 Dec 1;143(23):4521-4532. 

Yannick Elipot, Hélène Hinaux, Jacques Callebert, Jean-Marie Launay, Maryline Blin and Sylvie Rétaux (2014) A Mutation in theEnzyme Mono Amine Oxidase explains part of the Astyanax Cavefish Behavioural Syndrome. Nature Communications, 5:3647. IF10.

Yannick Elipot, Laurent Legendre, Stéphane Père, Frédéric Sohm and Sylvie Rétaux (2014) Astyanax transgenesis and husbandry:how cavefish enters the lab. Zebrafish, 11(4):291-9. IF3 (with cover picture)

Luis Espinasa, Jonathan Bibliowicz, William R. Jeffery, and Sylvie Rétaux. (2014) Enhanced prey capture skills in Astyanax cavefishlarvae are independent from eye loss. Evo Devo 5: 35.

Suzanne E. McGaugh, Joshua B. Gross, Bronwen Aken, Maryline Blin, Richard Borowsky, Domitille Chalopin, Hélène Hinaux, WilliamJeffery, Alex Keene, Li Ma, Pat Minx, Daniel Murphy, Kelly E. O’Quin, Sylvie Rétaux, Nicolas Rohner, Steve M. J. Searle, BethanyStahl, Cliff Tabin, Jean-Nicolas Volff, Masato Yoshizawa, Wes C. Warren. (2014) The cavefish genome reveals candidate genes foreye loss. Nature Communications, Oct 20; 5:5307.

Hélène Hinaux, Maryline Blin, Julien Fumey, Laurent Legendre, Didier Casane and Sylvie Rétaux (2014) Lens defects in Astyanaxmexicanus cavefish: focus on crystallin evolution and function. Developmental Neurobiology, 28. [Epub ahead of print].

Brain development, repair and ageing

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Alzheimer's disease
synaptic development
post-lesion repair
non-invasive brain stimulation

ENP label: 

2015

Research Center / Institute: 

Institut de Biologie Paris Seine

Research Unit Code: 

UMR8256

BDRA studies mechanisms underlying the development, repair and ageing of the brain, using cerebellar and hippocampal models in vivo and in vitro, to address fundamental biological bases of these phenomena and to explore clinical applications.

The team’s multidisciplinary approach, from molecules to behavior and bench to the clinic, expands the Unit’s research fields into the evolution of accumulating synaptic dysfunction with time and the potential for its repair.

Leader

Leader: 

Co leader: 

Institutions

Principal Institution: 

UPMC

Affiliated institutions: 

CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED3C 158
Laboratory

Surname: 

Biological Adaptation and Ageing

Initiatives d'Excellence: 

LabEx Biopsy, Udex Super de l'UPMC, DHU FAST
Publications

Publications: 

Grehl S, Martina D, Goyenvalle C, Deng ZD, Rodger J, Sherrard RM. In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields. Front Neural Circuits. 2016 Nov 3;10:85. 

Vernet-der Garabedian B#, Derer P#, Bailly Y, Mariani J# (2013) Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum J Neuroinflamm.;10:65.

Chen XR Heck N Lohof AM# Rochefort C Morel MP Wehrle R Doulazmi M# Marty S Cannaya V Avci HX# Mariani J# Rondi-Reig L Vodjdani G Sherrard RM# Sotelo C Dusart I (2013) Mature Purkinje cells require RORalpha to maintain climbing fiber mono-innervation and other adult characteristics. J Neurosci. 33(22):9546-62.

Makowiecki K, Harvey AR, Sherrard RM#, Rodger J (2014) Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice. J Neurosci 34:10780-10792

Grehl S#, Viola H, Fuller-Carter PI, Carter KW, Dunlop SA, Hool L, Sherrard RM*#, Rodger J*# (2015) Cellular and molecular changes to cortical neurons following low intensity repetitive magnetic stimulation at different frequencies. Brain Stim 8:114-123 *=co-senior

Cifuentes D, Poittevin M, Dere E#, Broqueres-You, D, Bonnin P, Benessiano J, Pocard M, Mariani J#, Kubis N, Merkulova-Rainon T, Lévy B (2014) Hypertension accelerates the progression of Alzheimer-Like pathology in a mouse model of the disease. Hypertension, (Oct 20)