UMRS 1127 UMR 7225

Brain Development Team

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

Brain Development, Neuronal networks, Genetic regulation, Drosophila, Mouse

ENP label: 

2017

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Our lab is interested in how a brain develops and how it is protected from disorders, like intellectual disability and neurodegeneration.Although the emphasis in the media and, even the scientific literature tends to be on brain disease, it is worth remembering that vastmajority of people - and indeed animals - are in fact healthy and do not suffer from brain disorders. In fact, brain health is so robustthat often even individuals with mutations that could lead to disease do not develop the symptoms. How does brain developmentresist dysregulation more than 95% of the time?

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

Doctoral School: 

ED 3C - 158
Laboratory

Initiatives d'Excellence: 

Allen Distinguished Investigator Award 2016
Publications

Publications: 

Hassan, B. A. and P. Robin Hiesinger. 2015. Beyond Molecular Codes: Simple Rules to Wire Complex Brains. Cell 163:285-91.

Okray, Z., C E.F. de Esch, H. Van Esch, K. Devriendt, A. Claeys, J. Yan, J. Verbeeck, G. Froyen, R. Willemsen, F. M.S. de Vrij, and B. A. Hassan. 2015. A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function. EMBO Mol. Med. 7:423-37.

Langen M., M. Koch, J. Yan, N. De Geest, M-L Erfurth, B. D. Pfeiffer, D. Schmucker, Y. Moreau and B. A. Hassan. 2013. Mutual inhibition among neighboring postmitotic neurons regulates individuality and robustness of brain wiring. eLife 2:e00337.

Xiao-Jiang Quan, Liqun Yuan, Luca Tiberi, Annelies Claeys, Natalie De Geest, Jiekun Yan, Rob van der Kant, Wei R. Xie, Tiemo J. Klisch, Joost Shymkowitz, Frederic Rousseau, Mathieu Bollen, Monique Beullens, Huda Y. Zoghbi, Pierre Vanderhaeghen, Bassem A. Hassan. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis.

FRONTlab: the frontal systems, functions and dysfunctions

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

cognition
behavior
executive functions
neuroimaging
Prefrontal cortex

ENP label: 

2016

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.

Leader

Leader: 

Personal

Team members: 

Bruno DUBOIS Chef d'équipe
Antoni VALERO-CABRE
Benedicte BATRANCOURT
Emmanuelle VOLLE
Harald HAMPEL
Raffaella Lara MIGLIACCIO
Marc TEICHMAN
Michel THIEBAUT DE SCHOTTEN
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
UPMC
Publications

Publications: 

Azuar C, Reyes P, Slachevsky A, Volle E, Kinkingnehun S, Kouneiher F, Bravo E, Dubois B, Koechlin E, Levy R. Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions. Neuroimage. 2014 Jan 1;84:1053-60. doi: 10.1016/j.neuroimage.2013.09.031.

Aichelburg C, Urbanski M, Thiebaut de Schotten M, Humbert F, Levy R, Volle E. Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities. Cereb Cortex. 2014 Oct 19. pii: bhu254. 

Lagarde J, Valabrègue R, Corvol JC, Garcin B, Volle E, Le Ber I, Vidailhet M, Dubois B, Levy R. Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’. Brain. 2015 Feb;138(Pt 2):456-71. doi: 10.1093/brain/awu359. 

Gil Gonen-Yaacovi Leonardo Cruz de Souza Richard Levy Marika Urbanski Goulven Josse Emmanuelle Volle. Rostral and caudal prefrontal contribution to creativity: A meta-analysis of functional imaging data. Front. Hum. Neurosci. Published on 14 Aug 2013, doi:10.3389/fnhum.2013.00465. 

Thiebaut de Schotten M., Dell’Acqua F., Forkel S.J., Simmons A., Vergani F., Murphy D.G.M., Catani M. (2011) A lateralized brain network for visuospatial attentionNat Neurosci 14:1245-1246.(IF 14.191).

ALS causes and mechanisms of motor neuron degeneration

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Amyotrophic Lateral Sclerosis (ALS)
genetics
motor neurons degeneration
neuroimmunology
iPSc

ENP label: 

2016

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Our second aim is to assess the crucial question whether different ALS genes lead to motor neuron death and deleteriousmicroglia/macrophage responses by gain or loss of function mechanisms. A major focus will be on newly discovered and theremaining unknown ALS genes with approaches including novel mouse modeling and gene discovery.Our project relies on the combined capacities of 4 PIs and 2 supporting clinicians forming this ALS team.

Leader

Leader: 

Institutions

Doctoral School: 

ED 158 3C
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, Labex revive
Publications

Publications: 

Phenotype difference between ALS patients with expanded repeats in C9ORF72 and patients with mutations in other ALS-related genes. Millecamps S, Boillée S, Le Ber I, Seilhean D, Teyssou E, Giraudeau M, Moigneu C, Vandenberghe N, Danel-Brunaud V, Corcia P, Pradat PF, Le Forestier N, Lacomblez L, Bruneteau G, Camu W, Brice A, Cazeneuve C, Leguern E, Meininger V, Salachas F. J Med Genet. 2012 Apr;49(4):258-63.

Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis. Teyssou E, Chartier L, Amador MD, Lam R, Lautrette G, Nicol M, Machat S, Da Barroca S, Moigneu C, Mairey M, Larmonier T, Saker S, Dussert C, Forlani S, Fontaine B, Seilhean D, Bohl D, Boillée S, Meininger V, Couratier P, Salachas F, Stevanin G, Millecamps S. Neurobiol Aging. 2017 Oct;58:239.e11-239.e20

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S. Brain. 2015 Jan;138(Pt 1):53-68.

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92.

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Lelli A, Gervais A, Colin C, Chéret C, Ruiz de Almodovar C, Carmeliet P, Krause KH, Boillée S, Mallat M. Glia. 2013 Sep;61(9):1542-55.

 

PICNIC Lab Physiological Investigations of Clinically Normal & Impaired Cognition

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

ENP label: 

2014

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The PICNIC lab is devoted to the study of cognitive functions with an exclusive or prevalent development in humans, namely language and conscious cognition. The study of brain-damaged patients occupies a central position in our methodological approach. For the study of both language and consciousness, and with both patients and healthy subjects, we resort to state-of-the-art behavioural methods and multimodal brain imaging (MRI, high-density surface EEG and intracerebral implanted electrodes).

Leader

Leader: 

Co leader: 

Personal

ENP Students: 

Team members: 

Paolo BARTOLOMEO
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

Université Pierre et Marie Curie
CNRS
Université Paris 6

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Initiatives d'Excellence: 

Contrat ANR, ICM Big Brain Theory Program, Idex Sorbonne université
Publications

Publications: 

 

Mongelli, V., Dehaene, S., Vinckier, F., Peretz, I., Bartolomeo, P., & Cohen, L. (2016). Music and words in the visual cortex: The impact of musical expertise. Cortex. doi: 10.1016/j.cortex.2016.05.016

Lunven, M., Thiebaut de Schotten, M., Bourlon, C., Duret, C., Migliaccio, R., Rode, G., & Bartolomeo, P. (2015). White matter lesional predictors of chronic visual neglect: a longitudinal study. Brain, 138, 746-760.

Sitt*, J., King*, J. R., El Karoui, I., Rohaut, B., Faugeras, F., Gramfort, A., Cohen, L., Sigman, M., Dehaene, S., & Naccache, L. (2014). Large scale screening of neural signatures of consciousness in patients in a vegetative or minimally conscious state. Brain, 137, 2258-2270.

Bouhali, F., Thiebaut de Schotten, M., Pinel, P., Poupon, C., Mangin, J. F., Dehaene, S., & Cohen, L. (2014). Anatomical Connections of the Visual Word Form Area. Journal of Neuroscience, 34(46), 15402-15414.  

King*, J. R., Sitt*, J., Faugeras, F., Rohaut, B., El Karoui, I., Cohen, L., Naccache, L., & Dehaene, S. (2013). Information Sharing in the Brain Indexes Consciousness in Noncommunicative Patients. Current Biology, 23(19), 1914-1919.

Social and Affective Neuroscience Team (SAN)

Main field of research: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Keywords: 

Depression
psychiatry
MEG
emotion
perception
social processes
social and affective neuroscience
EEG
fMRI

ENP label: 

2014

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The SAN team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry. Our project focuses on the functional neuroanatomy of the emotional brain. We study the brain systems of emotion detection, evaluation, and regulation, with an emphasis on how social processes (eg social inclusion) activate and regulate the emotional brain. Dysfunction of the emotional brain is central to many mental disorders and in particular to major depressive disorder (MDD).

Leader

Leader: 

Personal

Team members: 

MILLET Bruno
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 158
Laboratory

Initiatives d'Excellence: 

Institute for Translational Neuroscience (IHU-A-ICM), Paris
Publications

Publications: 

Mauras, T., Masson, M., Fossati, P*., & Pessiglione, M*. (2016). Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. Journal of Clinical Psychiatry, 77(6), E697-+. * equal contribution

Rotge, J. Y., Poitou, C., Fossati, P., Aron-Wisnewsky, J., & Oppert, J. M. (2017). Decision-making in obesity without eating disorders: a systematic review and meta-analysis of Iowa gambling task performances. Obes Rev.

Resibois, M., Verduyn, P., Delaveau, P., Rotge, J. Y., Kuppens, P., Van Mechelen, I., & Fossati, P. (2017). The neural basis of emotions varies over time: Different regions go with onset- and offset-bound processes underlying emotion intensity. Soc Cogn Affect Neurosci. doi: 10.1093/scan/nsx051. [Epub ahead of print]

Delaveau, P., Arruda Sanchez, T., Steffen, R., Deschet, K., Jabourian, M., Perlbarg, V., Gasparetto, E. L., Dubal, S., Costa, E. S. J., & Fossati, P. (2017). Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms. Hum Brain Mapp.

Burra, N., Baker, S., & George, N. (2017). Processing of gaze direction within the N170 / M170 time window: A combined EEG / MEG study. Neuropsychologia.

 

Cellular Physiology of Cortical Microcircuits

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

Inhibition
cerebral cortex
interneurons
synaptic transmission
GABA

ENP label: 

2011

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

In the cerebral cortex the constant computation of incoming sensory information is dynamically integrated to provide a coherent representation of the world and generate highly sophisticated cognitive functions. Cortical circuits are made of different neuron types connecting one another through a staggering number of synaptic connections that are responsible for the propagation of information between neurons.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Initiatives d'Excellence: 

LabEX BioPsy, ENI-Net
Publications

Publications: 

Baptista S, Lourenço J, Milhazes N, Borges F, Silva AP, Bacci A. Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons. eNeuro. 2016 Jul 11;3(3). pii: ENEURO.0141-16.2016. doi: 10.1523/ENEURO.0141-16.2016. eCollection 2016 May-Jun.

Lourenço J, Pacioni S, Rebola N, van Woerden GM, Marinelli S, DiGregorio D, Bacci A (2014) Non-associative potentiation ofperisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons PLoS Biology 12:e1001903

Antonucci F, Corradini I, Morini R, Fossati G, Menna E, Pozzi D, Pacioni S, Verderio C, Bacci A, Matteoli M (2013) Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses EMBO Rep. 14:645-51.

 

Cortex and Epilepsy

Keywords: 

Epilepsie
neurone-synapse-circuit
in vitro

ENP label: 

2007

Research Unit Code: 

UMRS 1127 UMR 7225
  • Cortex, Hippocampus, Epilepsy, Slice.
  • Physiology, Anatomy, Pathology.       
  • Human epileptic tissue.  Dcx, KA.       
  • Presubiculum, EEG, Synapse, Circuit.
Institutions

Principal Institution: 

Université Pierre et Marie Curie

Affiliated institutions: 

Inserm
CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Publications

Publications: 

Huberfeld G, Menendez de la Prida L, Pallud J, Cohen I, Le Van Quyen M, Adam C, Clemenceau S,  Baulac M & Miles R. (2011)  Glutamatergic preictal discharges emerge at the transition to seizure in the  human epileptic temporal lobe.  Nature Neurosci. 14: 627-34.

Bazelot M, Dinocourt C, Cohen I & Miles R (2010)  Inhibitory field potentials in the CA3 region of rat hippocampus.    J Physiology 588: 2077-90.

Motti D, Le Duigou C, Eugene E, Chemaly N, Wittner L, Lazarevic D, Krmac H, Marstrand T, Valen E, Sanges R, Stupka E, Sandelin A, Cherubini E, Gustincich S & Miles R  (2010)  Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus.    European J Neuroscience 32: 1364-79.

Wittner L, Huberfeld G, Clémenceau S, Erőss L, Dezamis E, Entz L, Ulbert I, Baulac M, Freund TF, Maglóczky Zs &  Miles R. (2009)  The epileptic human hippocampal CA2 region generates spontaneous interictal like activity in vitro.  Brain 132: 3032-46.          

Eugene E, Delpiel C, Baulac S, Baulac M,  Fritschy JM, LeGuern E, Miles R & Poncer JC   (2007) Synaptic and non-synaptic effects of GABRG2 mutations linked to human epileptic syndromes.  J Neurosci 27: 14108-16.

Behavior, Emotion and Basal Ganglia

Main field of research: 

Neurological and psychiatric diseases

Keywords: 

Parkinson
Tourette
basal
ganglia
Depression
psychiatry
Experimental Psychology
refractory disease
OCD
translational medicine

ENP label: 

2007

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

The scientific core of our research program is to study the exact nature of the processing that the basal ganglia (BG) apply to cortical information with three perspectives: 1) improve our fundamental knowledge of the cerebral mechanisms of information processing; 2) better understand the pathophysiology of human diseases which are related to BG dysfunction; and 3) develop innovative treatments for neuropsychiatric refractory disorders notably by means of the deep brain stimulation (DBS) functional neurosurgery.

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Surname: 

SERBERA Marie-Catherine

Initiatives d'Excellence: 

IHU ICM
Publications

Publications: 

Morgiève M#, N'Diaye K#, Haynes WI#, Granger B, Clair AH#, Pelissolo A, Mallet L#. Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging. Psychol Med. 2014 May;44(7):1461-73.

Burbaud P#, Clair AH#, Langbour N, Fernandez-Vidal S#, Goillandeau M, Michelet T, Bardinet E#, Chéreau I, Durif F, Polosan M, Chabardès S, Fontaine D, Magnié-Mauro MN, Houeto JL, Bataille B, Millet B, Vérin M, Baup N, Krebs MO, Cornu P, Pelissolo A, Arbus C, Simonetta-Moreau M, Yelnik J#, Welter ML, Mallet L#. Neuronal activity correlated with checking behaviour in thesubthalamic nucleus of OCD patients. Brain, 2013 Jan;136(Pt 1):304-17

Clair AH#, N'Diaye K#, Baroukh T, Pochon JB, Morgieve M#, Hantouche E, Falissard B, Pelissolo A, Mallet L#. Excessive checking for non-anxiogenic stimuli in obsessive-compulsive disorder. Eur Psychiatry 2012. 10.1016

Buot A#, Welter ML, Karachi C, Pochon JB, Bardinet E#, Yelnik J#, Mallet L#. Processing of emotional information in the human subthalamic nucleus. J Neurol Neurosurg Psychiatry 2012. 10.1136/jnnp-2011-302158

Palminteri S, Clair AH#, Mallet L#, Pessiglione M. Similar improvement of reward and punishment learning by serotonin reuptakeinhibitors in obsessive-compulsive disorder. Biol Psychiatry 2012; 72: 244-250.

CENIR NeuroImaging

Main field of research: 

Neurophysiology / systems neuroscience

Keywords: 

MEG
EEG
IRM
Neurophysiology
Cognitive science
Pathologies cérébrales
Pathologies médullaires

ENP label: 

2007

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

Le CENIR a pu commencer ses activités de recherche en neuro-imagerie grâce à la coopération financière de grandes institutions publiques et de prestigieux partenaires privés. L'ENP a cofinancé l'antenne tête 32 canaux et 100% de leur système EEG. 

Leader

Leader: 

Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, FLI, Neuratris
Publications

Publications: 

Gargouri F, Messé A, Perlbarg V, Valabregue R, McColgan P, Yahia-Cherif L, Fernandez-Vidal S, Ben Hamida A, Benali H, Tabrizi S, Durr A, Lehéricy S. Longitudinal changes in functional connectivity of cortico-basal ganglia networks in manifests and premanifest huntington's disease. Hum Brain Mapp. 2016 Jul 12. doi: 10.1002/hbm.23299. 

Rosso C, Valabregue R, Arbizu C, Ferrieux S, Vargas P, Humbert F, Attal Y, Messé A, Zavanone C, Meunier S, Cohen L, Delmaire C, Thielscher A, Herz DM, Siebner HR, Samson Y, Lehéricy S. The eye of the self: precuneus volume and visual perspective during autobiographical memory retrieval. Brain Struct Funct. 2014 May;219(3):959-68. doi: 10.1007/s00429-013-0546-2. Epub 2013 Apr 4.

Fasoula A, et al. Comparative performance evaluation of data-driven causality measures applied to brain networks. J Neurosci Methods (2013), http://dx.doi.org/10.1016/j.jneumeth.2013.02.021

Attal Y, Schwartz D Assessment of Subcortical Source Localization Using Deep Brain Activity Imaging Model with Minimum Norm Operators: A MEG Study. PLoS ONE (2013) 8(3): e59856. doi:10.1371/journal.pone.0059856

Dalal, SS., Jerbi, K., Bertrand, O., Adam, C., Ducorps, A., Schwartz, D., Garnero, L., Baillet, S., Martinerie, J., Lachaux, J-P. Evidence for MEG detection of hippocampus oscillations and cortical gamma-band activity from simultaneous intracranial EEG. Epilepsy & Behavior (2013) 28 (2), 310-311. Dio: 10.1016/j.yebeh.2012.04.032

Ulloa, J.L., Puce, A., Hugueville, L., & George, N. (2013). Sustained neural activity to gaze and emotion perception in dynamic social scenes. SCAN, in press. doi: 10.1093/scan/nss141

Dumas, T., Dubal, S., Attal, Y., Morel, S., Chupin, M., Jouvent, R., & George, N. (2013). MEG evidence for early amygdala responses to fearful faces in healthy adults. PloS ONE, 8(9): e74145. oi:10.1371/journal.pone.0074145.

Genetics and physiopathology of epilepsy

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

human genetics
Epilepsy molecular and cellular brain development
Transmission synaptique Epilepsie Cortex
physiopathology

ENP label: 

2009

Research Center / Institute: 

Institut du Cerveau et de la Moelle épinière

Research Unit Code: 

UMRS 1127 UMR 7225

O

Leader

Leader: 

Co leader: 

Personal

Team members: 

Elise Marsan
Christel Depienne
Virginie Lambrecq
Eric Noé
Théo Ribierre
GIuseppe Muraca
Manon Quiquand
Institutions

Principal Institution: 

Inserm

Affiliated institutions: 

CNRS
Université Pierre et Marie Curie

Doctoral School: 

ED3C - n°158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM; ERC Consolidator Grant
Publications

Publications: 

Boillot M, Lee CY, Allene C, Leguern E, Baulac S*, Rouach N* (2016). LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Scientific Reports. Feb 16;6:21769. *co-last

Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. (2016) Depdc5 knockout rat: A novel model of mTORopathy. Neurobiol Dis 89:180-189.

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S. (2016) Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 57:994-1003. Article awarded the 2017 Clinical Epilepsia Prize.

Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E, Andermann F, Leguern E, Chassoux F, Picard F (2015). Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol. Apr;77(4):675-83. Article highlighted as Best Advances of 2015: Picks from the Neurology Today Editorial Advisory Board

Ishida S, Picard F, Rudolf G, Noé E, Achaz G, Thomas P, Genton P, Mundwiller E, Wolff M, Marescaux C, Miles R, Baulac M, Hirsch E, Leguern E and Baulac S (2013). Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nature Genetics, Apr 26;45(5):552-5. Highlighted in Nature Review Neurology