UMRS 1127 UMR 7225
Our lab is interested in how a brain develops and how it is protected from disorders, like intellectual disability and neurodegeneration.Although the emphasis in the media and, even the scientific literature tends to be on brain disease, it is worth remembering that vastmajority of people - and indeed animals - are in fact healthy and do not suffer from brain disorders. In fact, brain health is so robustthat often even individuals with mutations that could lead to disease do not develop the symptoms. How does brain developmentresist dysregulation more than 95% of the time?
The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.
Our second aim is to assess the crucial question whether different ALS genes lead to motor neuron death and deleteriousmicroglia/macrophage responses by gain or loss of function mechanisms. A major focus will be on newly discovered and theremaining unknown ALS genes with approaches including novel mouse modeling and gene discovery.Our project relies on the combined capacities of 4 PIs and 2 supporting clinicians forming this ALS team.
The PICNIC lab is devoted to the study of cognitive functions with an exclusive or prevalent development in humans, namely language and conscious cognition. The study of brain-damaged patients occupies a central position in our methodological approach. For the study of both language and consciousness, and with both patients and healthy subjects, we resort to state-of-the-art behavioural methods and multimodal brain imaging (MRI, high-density surface EEG and intracerebral implanted electrodes).
The SAN team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry. Our project focuses on the functional neuroanatomy of the emotional brain. We study the brain systems of emotion detection, evaluation, and regulation, with an emphasis on how social processes (eg social inclusion) activate and regulate the emotional brain. Dysfunction of the emotional brain is central to many mental disorders and in particular to major depressive disorder (MDD).
In the cerebral cortex the constant computation of incoming sensory information is dynamically integrated to provide a coherent representation of the world and generate highly sophisticated cognitive functions. Cortical circuits are made of different neuron types connecting one another through a staggering number of synaptic connections that are responsible for the propagation of information between neurons.
- Cortex, Hippocampus, Epilepsy, Slice.
- Physiology, Anatomy, Pathology.
- Human epileptic tissue. Dcx, KA.
- Presubiculum, EEG, Synapse, Circuit.
The scientific core of our research program is to study the exact nature of the processing that the basal ganglia (BG) apply to cortical information with three perspectives: 1) improve our fundamental knowledge of the cerebral mechanisms of information processing; 2) better understand the pathophysiology of human diseases which are related to BG dysfunction; and 3) develop innovative treatments for neuropsychiatric refractory disorders notably by means of the deep brain stimulation (DBS) functional neurosurgery.
Le CENIR a pu commencer ses activités de recherche en neuro-imagerie grâce à la coopération financière de grandes institutions publiques et de prestigieux partenaires privés. L'ENP a cofinancé l'antenne tête 32 canaux et 100% de leur système EEG.