UMR3738

Zebrafish Neurogenetics (ZEN)

Main field of research: 

Neurogenetics / neurodevelopment

Keywords: 

zebrafish
behavior
motivation
neurogenesis
stem cell
telencephalon
quiescence

ENP label: 

2009

Research Center / Institute: 

Institut Pasteur

Research Unit Code: 

UMR3738

The central nervous system (CNS) of vertebrates is a complex arrangement of neurons and glial cells that underlie brain physiology and animal behavior. These cells are set-up in defined numbers at specific locations from neural progenitors or Neural Stem Cells (NSCs), largely during early stages of life. In addition, the maintenance of NSCs in the brain until adulthood is a general phenomenon, likely crucial to late adaptation events. Indeed, defects in adult neurogenesis have been correlated with neurodegenerative and mood-related disorders, and also occur during ageing.

Leader

Leader: 

Personal

ENP Students: 

Team members: 

Alessandro Alunni
Marion Coolen
Institutions

Principal Institution: 

CNRS

University: 

Université Pierre et Marie Curie

Doctoral School: 

ED 515 Complexité du Vivant
Laboratory

Surname: 

Department of Developmental and stem cell Biology

Initiatives d'Excellence: 

Labex Revive
Publications

Publications: 

L. Dirian, S. Galant, M. Coolen, J. Livet, W. Chen, S. Bedu, C. Houart, L. Bally-Cuif* and I. Foucher*. Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells. Dev. Cell 30:123-136 (2014).

G. FurlanV. Cuccioli, N. Vuillemin, L. Dirian, A. Janue Muntasell, M. CoolenN. DrayS. Bedu, C. Houart, E. Beaurepaire, I. Foucher*and L. Bally-Cuif*. Life-long neurogenic activity of individual neural stem cells and continuous growth establish an outside-in architecture in the teleost pallium. Curr. Biol., in press (2017). * co-senior authorship. 

S. KatzD. Cussigh, N. Urban, F. Guillemot, L. Bally-Cuif* and M. Coolen*. A non-canonical nuclear role for microRNA-9 and Argonaute proteins in balancing the quiescent and activated adult neural stem cell state. Cell Reports 17: 1383-1398 (2016).    

S. GalantG. FurlanM. CoolenL. DirianI. Foucher and L. Bally-CuifEmbryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain. Dev Biol. pii: S0012-1606(16)30424-9 (2016).

N. DrayS. Bedu, N. Vuillemin, A. AlunniM. CoolenM. Krecsmarik, W. Supatto, E. Beaurepaire and L. Bally-Cuif. Large-scale live imaging of adult neuro stem cells in their endogenous niche. Development 142: 3592-3600 (2015).